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Database: UniProt
Entry: A0A0V1LNC5_9BILA
LinkDB: A0A0V1LNC5_9BILA
Original site: A0A0V1LNC5_9BILA 
ID   A0A0V1LNC5_9BILA        Unreviewed;      2112 AA.
AC   A0A0V1LNC5;
DT   16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT   16-MAR-2016, sequence version 1.
DT   28-MAR-2018, entry version 15.
DE   RecName: Full=Voltage-dependent L-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
DE   Flags: Fragment;
GN   Name=Ca-alpha1D {ECO:0000313|EMBL:KRZ60860.1};
GN   ORFNames=T02_6857 {ECO:0000313|EMBL:KRZ60860.1};
OS   Trichinella nativa.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC   Trichinellida; Trichinellidae; Trichinella.
OX   NCBI_TaxID=6335 {ECO:0000313|EMBL:KRZ60860.1, ECO:0000313|Proteomes:UP000054721};
RN   [1] {ECO:0000313|EMBL:KRZ60860.1, ECO:0000313|Proteomes:UP000054721}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISS10 {ECO:0000313|EMBL:KRZ60860.1};
RA   Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT   "Evolution of Trichinella species and genotypes.";
RL   Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1C
CC       gives rise to L-type calcium currents. Long-lasting (L-type)
CC       calcium channels belong to the 'high-voltage activated' (HVA)
CC       group. They are blocked by dihydropyridines (DHP),
CC       phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA
CC       (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-
CC       GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA).
CC       Calcium channels containing the alpha-1C subunit play an important
CC       role in excitation-contraction coupling in the heart. Binding of
CC       calmodulin or CABP1 at the same regulatory sites results in
CC       opposite effects on the channel function.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KRZ60860.1}.
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DR   EMBL; JYDW01000024; KRZ60860.1; -; Genomic_DNA.
DR   Proteomes; UP000054721; Unassembled WGS sequence.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.120.350; -; 4.
DR   InterPro; IPR031688; CAC1F_C.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR005446; VDCC_L_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16885; CAC1F_C; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01630; LVDCCALPHA1.
DR   SMART; SM01062; Ca_chan_IQ; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000054721};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAAS:SAAS00085096, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054721};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00084820,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00084701,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM    108    127       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    177    198       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    210    230       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    270    289       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    351    372       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    384    406       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    515    531       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    551    576       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    583    601       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    638    658       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    679    696       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    708    731       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    876    894       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    914    935       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    947    973       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1008   1027       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1118   1145       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1199   1217       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1229   1249       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1269   1286       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1298   1316       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1362   1382       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1448   1472       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1628   1662       Ca_chan_IQ. {ECO:0000259|SMART:SM01062}.
FT   COILED      749    769       {ECO:0000256|SAM:Coils}.
FT   COILED     1774   1794       {ECO:0000256|SAM:Coils}.
FT   NON_TER       1      1       {ECO:0000313|EMBL:KRZ60860.1}.
SQ   SEQUENCE   2112 AA;  241160 MW;  350CFBB7D200AD35 CRC64;
     LYTDHARSEA NFNDDVNIGK ELSGNEAAAL LHGDEARASR ADLWQQTLQA AVAAQTESST
     TTKKRQQQRK MQRNVQQERP ERSLLCLGLK NPIRKLFISI VEWKPFEWLI LCMICANCIA
     LAVYQPFPAH DSDRKNAVLQ NRKHKLNPQP GQRTATVAAV GHTGWGVGLF SEEQVEYIFI
     VVFTIECVMK VIAYGFLFHP GAYLRNGWNL LDFLIVVIGL ISTALSTLNI HGFDVKALRA
     FRVLRPLRLV SGVPSLQVVL NSILRAMVPL FHIALLVLFV IIIYAIIGLE LFCGKLHKTC
     VDQWTGEHVP DPGPCGESHT SFHCDRSKNL VCTENHTWPG PNDGITNFDN FGLAMLTVFQ
     CISLEGWTDV MYWVNDSVGR EWPWIYFITL VILGSFFVLN LVLGVLSGEF SKEREKARAR
     GLFQKFREKQ QLEDDLKGYL DWITQAEDID LVNEEDEEQE AMDREEFGAD GEGGEEGGSK
     EEFQRQSWFS MKIKRLKKLN RRCRRSCRRI VKSQAFYWLV IVLVFLNTMV LTSEHYGQPE
     WLDHFQEIAN LFFVVLFTLE MFLKMYSLGF VNYFVALFNR FDCFVVIGSI LEFALTFAGL
     MKPLGVSVLR SARLLRIFKV TKYWNSLRNL VASLLNSLRS IASLLLLLFL FIVIFALLGM
     QVFGGKFNTI DPNMNKPRAN FDTFVQALLT VFQILTGEDW NAVMYNGIAA FGGVHSIGVI
     VCIYFIVLFI CGNYILLNVF LAIAVDNLAD AESLTAAEKE EENKRANEAD PEDDMVVKAT
     ADEDAVSVGQ FHESGEVKLP FNEPTDAEDE HLASGDDDQE REMENQSQFK PTARPHRQSE
     LNLPKKTKPI PDASSLFLFS STNKVRIFCN KVINHSYFTN SVLVCILVSS AMLAAEDPLQ
     ASSFRNEVLN YFDYFFTTVF TIEISLKVLV YGLILHKGSF CRNAFNLLDM LVVGVSLTSF
     GLKSGAISVV KILRVLRVLR PLRAINRAKG LKHVVQCVIV AVKTIGNIML VTFMLEFMFA
     IIGVQIFKGS FFRCTDRARL TAEECKGTFI EFEGGDVTRP HVRNREWTNY DFNFDNVQNA
     MVALFVVSTF EGWPDLLHVA MDSSDEGIGP QYNARVSVAI FFITFIVVIA FFMMNIFVGF
     VIVTFQSEGE REYENCELDK NQRKCIEFAL TAKPQRRYIP KNRFQYKIWW FVTSQPFEYA
     IFIIIILNTL ILGMKHYKSS AAFDEALDVL NLFFTTVFAL EFICKLFALT FKHHKMTRTF
     DDVLDTMNLI FTGIFAMEFI LKVMAFRCKN YFGDAWNVFD FIIVLGSFID IIYGKVSPGS
     NIISINFFRL FRVMRLVKLL SRGEGIRTLL WTFMKSFQAL PYVALLIVLL FFIYAVIGMQ
     IFGKIALNSN TEIHRNNNFQ TFPSAVLVLF RSATGEAWQL IMLSCANTPA AMCDPESDDR
     GQPCGNDFAY PFFISFFMLC SFLIINLFVA VIMDNFDYLT RDWSILGPHH LDEFVRLWSE
     YDPDAKGRIK HLDVVTLLRK ISPPLGFGKL CPHRLACKRL VSMNMPLNSD GTVCFNSTLF
     ALVRTNLKIY TEERPFLFLK KSEKVESQSL VSSNIEEANE QLRAVIKRIW KRTPQRLLDE
     IVPPSGRDDE ITVGKFYATY LIQDYFRRFK KRKEVEQKET NMQGNITMSL QFGEEFPSDL
     EAFDVLIVFL HVLLLQAGLR TLHEIGPEIK RAISGNLETD WSKEFEEPQH RRDHSLFGTL
     VHALQAHYKP FIEGNLTNPA YSNVNGDLKS QEGDDEAEQQ HQQHQQEQQE QQQQLMFNKM
     NDLKSPPVKS DRDKISEFES DESVCNKPER RCNSFFSNIR RRMDSIVSPS IVLFDSDHDS
     SEHEMQERVR FVPRGSKPTG LSFEGSRWLP RKLSFRRTPI GGAAAVSNLQ QGNNKRLQFS
     NAIILDDSDP DSVLHSENVV DLTESGDDSK LSVSPPLELR DDAYYLDGID YNTWRPAPMG
     QGVRLRGRGN GRRKSRSMPL PHHEHQRNYA DVLVEKVLAD QGLGRYADPN LIRTTQLEIA
     EAYNMTEAQM HSAARSLMQR SPKYFEHMGG QRPADIKDFN QYSKTALLKP REINSSEEVD
     ISDDMNMFMS VV
//
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