ID A0A0V1LNH6_9BILA Unreviewed; 2443 AA.
AC A0A0V1LNH6;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=OTU domain-containing protein 5-A {ECO:0000313|EMBL:KRZ60754.1};
DE Flags: Fragment;
GN Name=otud5a {ECO:0000313|EMBL:KRZ60754.1};
GN ORFNames=T02_10719 {ECO:0000313|EMBL:KRZ60754.1};
OS Trichinella nativa.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6335 {ECO:0000313|EMBL:KRZ60754.1, ECO:0000313|Proteomes:UP000054721};
RN [1] {ECO:0000313|EMBL:KRZ60754.1, ECO:0000313|Proteomes:UP000054721}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS10 {ECO:0000313|EMBL:KRZ60754.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the XPC family. {ECO:0000256|ARBA:ARBA00009525}.
CC -!- SIMILARITY: Belongs to the peptidase M67C family.
CC {ECO:0000256|ARBA:ARBA00010981}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ60754.1}.
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DR EMBL; JYDW01000026; KRZ60754.1; -; Genomic_DNA.
DR STRING; 6335.A0A0V1LNH6; -.
DR Proteomes; UP000054721; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0061578; F:K63-linked deubiquitinase activity; IEA:InterPro.
DR GO; GO:0140492; F:metal-dependent deubiquitinase activity; IEA:InterPro.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR CDD; cd08066; MPN_AMSH_like; 1.
DR CDD; cd22752; OTU_OTUD5-like; 1.
DR Gene3D; 3.90.70.80; -; 1.
DR Gene3D; 3.40.140.10; Cytidine Deaminase, domain 2; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 1.20.58.80; Phosphotransferase system, lactose/cellobiose-type IIA subunit; 1.
DR Gene3D; 2.20.20.110; Rad4, beta-hairpin domain BHD1; 1.
DR Gene3D; 3.30.70.2460; Rad4, beta-hairpin domain BHD3; 1.
DR Gene3D; 3.90.260.10; Transglutaminase-like; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR018327; BHD_2.
DR InterPro; IPR004583; DNA_repair_Rad4.
DR InterPro; IPR000555; JAMM/MPN+_dom.
DR InterPro; IPR037518; MPN.
DR InterPro; IPR003323; OTU_dom.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR018325; Rad4/PNGase_transGLS-fold.
DR InterPro; IPR018326; Rad4_beta-hairpin_dom1.
DR InterPro; IPR018328; Rad4_beta-hairpin_dom3.
DR InterPro; IPR042488; Rad4_BHD3_sf.
DR InterPro; IPR044098; STAMBP/STALP-like_MPN.
DR InterPro; IPR036985; Transglutaminase-like_sf.
DR InterPro; IPR015063; USP8_dimer.
DR InterPro; IPR022771; WAPL_C.
DR InterPro; IPR012502; WAPL_dom.
DR PANTHER; PTHR12135:SF0; DNA REPAIR PROTEIN COMPLEMENTING XP-C CELLS; 1.
DR PANTHER; PTHR12135; DNA REPAIR PROTEIN XP-C / RAD4; 1.
DR Pfam; PF10403; BHD_1; 1.
DR Pfam; PF10404; BHD_2; 1.
DR Pfam; PF10405; BHD_3; 1.
DR Pfam; PF01398; JAB; 1.
DR Pfam; PF02338; OTU; 1.
DR Pfam; PF03835; Rad4; 1.
DR Pfam; PF08969; USP8_dimer; 1.
DR Pfam; PF07814; WAPL; 1.
DR SMART; SM01030; BHD_1; 1.
DR SMART; SM01031; BHD_2; 1.
DR SMART; SM01032; BHD_3; 1.
DR SMART; SM00232; JAB_MPN; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 2.
DR SUPFAM; SSF102712; JAB1/MPN domain; 1.
DR SUPFAM; SSF140856; USP8 N-terminal domain-like; 1.
DR PROSITE; PS50249; MPN; 1.
DR PROSITE; PS50802; OTU; 1.
DR PROSITE; PS51271; WAPL; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000054721};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 154..277
FT /note="OTU"
FT /evidence="ECO:0000259|PROSITE:PS50802"
FT DOMAIN 736..1240
FT /note="WAPL"
FT /evidence="ECO:0000259|PROSITE:PS51271"
FT DOMAIN 1539..1667
FT /note="MPN"
FT /evidence="ECO:0000259|PROSITE:PS50249"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 81..120
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 357..393
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 536..558
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1374..1402
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1423..1448
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1481..1526
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1700..1784
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2045..2065
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2389..2418
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 104..120
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 363..393
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1376..1390
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1720..1743
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1744..1767
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 2443
FT /evidence="ECO:0000313|EMBL:KRZ60754.1"
SQ SEQUENCE 2443 AA; 274624 MW; 889018ED3B2C5C4A CRC64;
LSNVMTILPK KKGGSKDSRS QSHDHSSSSS NSGSLNVEDA ALIGLRNAQH TTVDSPTVPR
RPVSHSAYDL PEGESVFFGS GSRKRLATVN PGRQERGHRT KQKNLSHTLP STSTAPVKQG
YNSEDEYDEE LNTGVDEDQL DRNFEDALKT AKGFIIKKMK ADGACLFRAV ADQVYGDQEM
HDTVRKLCIN YMKKNSDYFS QFVTESFSDY IARKSLSYSH GNHIEMQAMA ELFNRPIEVY
QYNIEPINTF LSNKNTNDPP IRLSYHRSIH YNSVVDPFKA TIGVGLGLPQ YFPGLAERNL
MNDARLISER DVIEEAMLKD KMDATDWEAT DEQLQEQIAC ESYLQWLADE RKRHGNVAED
AKGANSSKDS SATEDNTSRK LPACGDTAQD LTSQPSTSQF LLNDYTLTGW NAEEELLNHV
LALSQQEYID SLSHKREDED SACCSSRDAV QSTTNIVSEY PQSENSNDSN QTYAKVKGLN
GCSRVTHETK ADTASALFDA VLEDIKSHES CATASSSVLA GKAKFGNRSK NLVSEAPATS
HADFSEAEAL PDSQDSQKSF SRGIANICLN EEAGLPSVDA GLSSPVSATN CSKRFFSDKH
GQFASSVSPS KRKATQLKED RQVDASSVYS FEEEEEEDKV GLTELETDVE YPTKFLTSKT
WKSVYQHKWN TDSSSPNAKS SSKTTFTKKE VNAAKAKHDI ATPSVSVSKF HGIRQRKTVK
SVVCGEEISQ NKTQCIRKEK PLYTVVRNVK QAHECHESGE AQEYNDDIVY LLGALSEENT
SNMRCLSLIT LLQKCVSAAF RNFLKAHGYA KQVLHALKDA HGNDCLALAT ACLFYLLSRD
RLCLVVDECS LGLLVNLVKP MKVDVTNEEF LKCKGKIWKV LCDWRTEVES SNIRKVLIMF
DLTEKNLNTS FLALESLVFI SSRSDSDAFK QEMRLNGGVE IAALRVADET KKISKAKGDE
ACIYPLLCLQ RALRILENVT TKASQNKGYL VTNDSLGMLD SLLTLFDFCL NGIIAKEKSM
PNVEDKNSPS AQVSSLLLIV FSELFRLLCN LSNNNEICCS KLSASGGFIR RCVECVTFYI
PRYLPESKRY DMQILFMSFV INYIEHHQSG RRVVIHSEVQ LLDGDKVISL PTVQALTRRI
ANAQSADDEM NNEIEGSSQT TAKSLDMQQK SFQETVKAAL VIASKHMEEC TVAAHVGLIL
GLLMQEDESI VSGIQHGMPG GTFKLVIETL EKFLDFMKEA NVTDAGAERT ITSPKMLVKE
ITSEASNIQF YPNIAMKKYA RSAGELYFIA GVYELDNNVE LAYRSYTRFI VLLVDHFPKH
PEYSKFCREE RDEYKKLMKN VRDAFDAAER LKVELTKQCE LQYMNALQKQ ANEVNNAKEQ
QREHKVTSTS ENSDYNHALS TNSTVSHGRV SNYYSQHDRV TPPAVVAPST SSVSHQDISR
ENDETNDTYT TFNVDDLIEL ENANNRAKTV GIPPTVVENL QAAESSSRPP KPTFDRSTKP
KLKTKTTTTT STPVRPPLPV VAPPPSSTPV SKYSGLQPVI IPKNLVFRFL DAAALNTAQE
IETCGILSGK LIQSSFVVTH VIVPKQSGTS NSCVAHHEEE MFTIQDDLGL ITLGWIHTHP
TQSAFLSSVD LHTHCSYQLL FPEAVAIVCA PKYNEIGVFM LTSPYGLKVI ANCKRTGFHP
HSQNPPVFQT CDHRPKWLLK QPGNAKLPRP PRRGASKRSQ ARACESTGQI DDSVGTVVEN
ESHAQLNDSK RNKRKRQRES GLHSRKEMKK GNSHKLRLSN SVVDDDDVDD DGECFSKPAN
AKMRNKISAC KPRKKCDENN DDSDHVVHKK REKKRIAKVK VVETNSSDSE WEDVKDVEII
DRPSTSTANI QLHFKQPENP SASKKKTLLQ RLVSKVTKLA RIRRHKVYLL AEIAHGIFLS
KCCNDEQVRA TAMSLIPIEM DIREPELRTR NFASKFIRWF HKNYPLKYLE PCGSLSTDPV
DYLLSKMSSG KIYSFRDWTL VFVSFARCIG FDVRIIMALR PTDMFDLSVT EVLVTDKLNE
KKAEKRKKLN SSSRVNDDRS NQDELGVSVE RKVADCQSIP PNNMCSASAH YCFSFDNEHA
VRDVTIRYAS NYGTVDFKRR RLSDSWFQLT LDLFQPANKL RNRLEDLFLE KMLSEKPLPK
KRSDYKNHPL YVLKRDLLKF EALYPADLQP VGYIGQEAVY PRTAVMNLKG KEAWIREARV
IKANEQPYKV VKGRPKMTVP KELRVDRPLN LYGIWQTEPY IPKPAEDGIV PKNEYGNVEL
YQMSMLPPGT VYMIQPGLLS IARKLNIDCA PAVVGWEFHC RSSHPIIEGC VVCKEHKEIL
EAAWLEEQVH IAVKEKERKT MRALKNWRKM VRSMLIKAKV EKKFLPSTKN AGSELSQSDG
QLIHNQRNNS TASTSVEDLN KSAWPQCRHQ FDMHFDTEER LSD
//
