ID A0A0V1LQ19_9BILA Unreviewed; 1950 AA.
AC A0A0V1LQ19;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE SubName: Full=Voltage-dependent T-type calcium channel subunit alpha-1H {ECO:0000313|EMBL:KRZ61608.1};
GN Name=Cacna1h {ECO:0000313|EMBL:KRZ61608.1};
GN ORFNames=T02_10899 {ECO:0000313|EMBL:KRZ61608.1};
OS Trichinella nativa.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6335 {ECO:0000313|EMBL:KRZ61608.1, ECO:0000313|Proteomes:UP000054721};
RN [1] {ECO:0000313|EMBL:KRZ61608.1, ECO:0000313|Proteomes:UP000054721}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS10 {ECO:0000313|EMBL:KRZ61608.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808}; Multi-
CC pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit (TC
CC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ61608.1}.
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DR EMBL; JYDW01000016; KRZ61608.1; -; Genomic_DNA.
DR STRING; 6335.A0A0V1LQ19; -.
DR Proteomes; UP000054721; Unassembled WGS sequence.
DR GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 5.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR002077; VDCCAlpha1.
DR InterPro; IPR043203; VGCC_Ca_Na.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10037:SF230; CA[2+]-CHANNEL PROTEIN ALPHA[[1]] SUBUNIT T, ISOFORM F; 1.
DR PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR PRINTS; PR00167; CACHANNEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PIRSR:PIRSR602077-1};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673,
KW ECO:0000256|RuleBase:RU003808};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568,
KW ECO:0000256|RuleBase:RU003808}; Coiled coil {ECO:0000256|SAM:Coils};
KW Ion channel {ECO:0000256|RuleBase:RU003808};
KW Ion transport {ECO:0000256|ARBA:ARBA00022568,
KW ECO:0000256|RuleBase:RU003808};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR602077-1};
KW Reference proteome {ECO:0000313|Proteomes:UP000054721};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022568, ECO:0000256|RuleBase:RU003808};
KW Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT TRANSMEM 40..59
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 133..156
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 257..275
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 295..321
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 759..778
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 805..827
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 898..924
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1307..1330
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1415..1434
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1515..1538
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1603..1624
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1636..1654
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1733..1752
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1825..1847
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..327
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 636..817
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1275..1547
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1601..1854
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 479..500
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1019..1050
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1856..1880
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1538..1582
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1021..1050
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1860..1874
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 276
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT BINDING 880
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT BINDING 1487
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
SQ SEQUENCE 1950 AA; 221146 MW; 07CD3CB5E69AC902 CRC64;
MMVILINCVT LGMYKPCDED MELAVCNTTR CITLSVIDHL VFAFFAVEMI IKIIAMGFYG
PDTYMSDTWN RLDFFIVIAG CAEYIFKERM GDINLTAIRT VRVLRPLRAI NRIPSMRILV
NLLLDTLPML GNVLLLCFFV FFIFGIIGVQ LWAGLLRNRC LLDLPSSNDS SLELMGLVRY
YMPDETSMEY ICSLEKDNGM HSCNNLQPST YNGHICNLTI DQWHAGNYTL SNSSCINWNQ
YYTKCGPTSH NPFQGSVSFD NIGFAWVSIY LVISLEGWSD IMYYVQDAHS FWDWIYFVLL
IVIGAFFMIN LCLVVIATQF ADTKRRETER MLAERARYPS TSTLTTIDQQ SDSDGVYRAI
VKYIAHLGRR AKRKAIRYYR EWKKRRANVA EIPSPHLITN SPKPAISQEA DPSQICLVPK
RFTYNSPRGD SLTIPCNSPT GLHSRGSSVS YYSTLEDSGL TIPAADYLPY SPARRYSSHR
RSRLVRSART SAGSADINRN GRKIKHHRLA SSKRYDPRFA LNYTESAPVC RPSFTGIRLR
IHREASTSSN SLSLDSEDEQ TALYLDDESS NRDEMDLELR KPYTDTDSEL DHDRVRFHTD
QLHLRNKRQN SSSDLLVRCL AFLKVCIKRF VDSDHFTRGI LVAILINTLS MGVEYHNQPE
ELTIILEYSN VFFTALFSIE MVLKIIADGP FTYVSNGFNL FDGGIVILSI MELLQGGNGG
LSVLRTFRLL RILKLVRFMP ALRYQLVVML RTMDNVTVFF GLLCLFIFIF SILGMNLFGC
KFCKQEMTAD GELVKSCDRK NFDSLFWATL TVFQIAFSII LLLHLFILLG MELFAGRFCQ
MPDGTPCHCK SKIPACKCPR RNFDTIINAA FTVFQILTQE DWNVVLFNGM AQTSPWSALY
FIALMTFGNY VLFNLLVAIL VEGFQESKAE ERRLMQEEID KTEIDPSTKT KENMFEVYKS
ENEKGEKSAI TCTCAAGVAA ATLLSSRSRD RLLSLPIMPV YVSGSELVNA PPPIIQTLPT
PVGSPVMSSP SARNCRKSGS KFDQNNDLSN GNSLYLPNSN AMSNSTISVK SHPLYKAGSH
RDGQTKRKLT GQQSITYLDI PNTKSGSCLR RHWSSSSSTT TFYSCVNTNT ESVATSSYKS
LESSQQEPVS VSTDASTNNQ CNGSVMMQSE VEFSPRKVSS QLSQQIYSSV NPHIFYPYCK
VHGYRLSLIG DGQKKEALLQ NSPLFIHDEL KAQLVARFHQ WFQQSWFQTR MDASLFIFMP
KNKFRAQCVY LSQQKWFDFC ILTFIGINCI TLAMERPGIP PNSIERLFLD ISGYIFTVIF
ALEMFIKVVA KSLVLGDGAY FKNGWDFMDG TLVLISLSNL IFDLLVKSHA PKIFSVVRVL
RLLRALRPLR VINRAPGVKL VVQTLISSLQ PIGNIVLICC TFFIIFGILG VQLFKGKMWH
CVGPNVAKVI NKTDCLADPH NRWINHRYNF DNLGQALMSL FVVSSKDGWV SIMYQGIDAV
GVDMQPVVNY FEWRMLYFIS FLLLVGFFVL NMFVGVVVEN FHRCKEALEK EMKEKEREKK
MRKRLQKQLS RQQLLIKRSK KLPYWYHYGP VRMYLHGIVT SKYFDLAISA VIGVNVITMA
MEFHMMPPEL TYALKVFNYF FTAIFTLEAI LKVFALSIPR YLKDRWNQLD VIIVLLSIGG
IVLEEMESNI LPINPTIMRV MRMLRIARVL KLLKMAKGIR SLLDTVMQAL PQVGNLGLLF
FLLFFIFAAL GVELFGRLEC SDEHPCDGLG EHAHFKNFGM AFLTLFRIAT GDNWNGIMKD
TLRDDCDNSD NCTSNCCVSA IIAPVYFVVF VLMAQFVLVN VVVAVLMKHL EESSKKMADG
SSEAGGSNAT DTDEKSCTLR GDSDDERALH AISSTTSLPT PQDLSKIELP DNPVKFWIPD
QSITQSDTLK KRNDKIDFDH QLDGLIENIV
//
