ID A0A0V1LQI5_9BILA Unreviewed; 743 AA.
AC A0A0V1LQI5;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Methionine synthase reductase {ECO:0000256|ARBA:ARBA00040659};
DE EC=1.16.1.8 {ECO:0000256|ARBA:ARBA00039088};
GN Name=MTRR {ECO:0000313|EMBL:KRZ61791.1};
GN ORFNames=T02_12793 {ECO:0000313|EMBL:KRZ61791.1};
OS Trichinella nativa.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6335 {ECO:0000313|EMBL:KRZ61791.1, ECO:0000313|Proteomes:UP000054721};
RN [1] {ECO:0000313|EMBL:KRZ61791.1, ECO:0000313|Proteomes:UP000054721}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS10 {ECO:0000313|EMBL:KRZ61791.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- COFACTOR:
CC Name=FMN; Xref=ChEBI:CHEBI:58210;
CC Evidence={ECO:0000256|ARBA:ARBA00001917};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ61791.1}.
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DR EMBL; JYDW01000014; KRZ61791.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V1LQI5; -.
DR STRING; 6335.A0A0V1LQI5; -.
DR Proteomes; UP000054721; Unassembled WGS sequence.
DR GO; GO:0010181; F:FMN binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.360; -; 1.
DR Gene3D; 3.40.50.80; Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR InterPro; IPR003097; CysJ-like_FAD-binding.
DR InterPro; IPR017927; FAD-bd_FR_type.
DR InterPro; IPR001094; Flavdoxin-like.
DR InterPro; IPR008254; Flavodoxin/NO_synth.
DR InterPro; IPR001709; Flavoprot_Pyr_Nucl_cyt_Rdtase.
DR InterPro; IPR029039; Flavoprotein-like_sf.
DR InterPro; IPR039261; FNR_nucleotide-bd.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR023173; NADPH_Cyt_P450_Rdtase_alpha.
DR InterPro; IPR001433; OxRdtase_FAD/NAD-bd.
DR InterPro; IPR017938; Riboflavin_synthase-like_b-brl.
DR PANTHER; PTHR19384:SF84; METHIONINE SYNTHASE REDUCTASE; 1.
DR PANTHER; PTHR19384; NITRIC OXIDE SYNTHASE-RELATED; 1.
DR Pfam; PF00667; FAD_binding_1; 1.
DR Pfam; PF00258; Flavodoxin_1; 1.
DR Pfam; PF00175; NAD_binding_1; 1.
DR PRINTS; PR00369; FLAVODOXIN.
DR PRINTS; PR00371; FPNCR.
DR SUPFAM; SSF52343; Ferredoxin reductase-like, C-terminal NADP-linked domain; 1.
DR SUPFAM; SSF52218; Flavoproteins; 1.
DR SUPFAM; SSF63380; Riboflavin synthase domain-like; 1.
DR PROSITE; PS51384; FAD_FR; 1.
DR PROSITE; PS50902; FLAVODOXIN_LIKE; 1.
DR PROSITE; PS51450; LRR; 1.
PE 4: Predicted;
KW Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00023167};
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW FMN {ECO:0000256|ARBA:ARBA00022643};
KW Methionine biosynthesis {ECO:0000256|ARBA:ARBA00023167};
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000054721}.
FT DOMAIN 25..169
FT /note="Flavodoxin-like"
FT /evidence="ECO:0000259|PROSITE:PS50902"
FT DOMAIN 338..582
FT /note="FAD-binding FR-type"
FT /evidence="ECO:0000259|PROSITE:PS51384"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KRZ61791.1"
SQ SEQUENCE 743 AA; 85618 MW; C2A6E90433EF932D CRC64;
LKRQYRYRYI YTCIYLYTKF MLNNFLIAYG SQTGQAKAIA LRLSEKCQAH NLTHRIHCLS
ANEKEFCIEK ERLVIFVVST TGDGEPPDSA HRFFTCLKRQ VRQKQKSLSN LKFALLGLGD
SNYNTFCGAP KALEKLLFQL HAKAFYPTGY CDEAVETATV AEPWICGLLE LLLSNNNLDS
IDKTLPLAKL SLEMENTEIA SLGSTPERLN GIMTPRSNGR ESQAIRCHME TDPNYRYDYY
YDDDQRRRGD QSTVDPTIAH SPSMPSRRPR FYTFEECQCR WAEPSVVGCE QLRNVIELKV
PSMALIVPKL TSIVTHEDYT QLNFPTTTPE TEYAGQASPR YMAKLLKRTV LTAPTAKKTK
VLLEFDLSGF DTPYKPGDAF SFICSNPQNE VNWLLYRMNL SVLADKRCTL KLLPEAERRG
DKLPPYLPEV SSLRYLFTHC LDIRQSPSRI LLRLFAEHCK TFGEKRRLME LCSSQGQQQY
QRYIRRAGLS LMDVLHAFPS CLPPVDRLIE LLPRLRPRPY SLACSPLVEE KRCNIVYSLV
SVTAEEGRFY ARNGLATGYF ETMQIGDQIE MFLRQSSNFC LPSDILNTPI VMIGPGTGVA
PFISFLQHIK ALSTEENRWC ERWLFYGCQF ESLDYIFRKQ LEDFHDSFLL THLVVSFSKE
EREDKAKYIQ DSIRDNGFSL VRLLTEMNQS RVYVCGDVEN MAKEVFQAFV DILQLHGEMS
ADDAKKFMSD LITNERYILD YWL
//
