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Database: UniProt
Entry: A0A0V1LR36_9BILA
LinkDB: A0A0V1LR36_9BILA
Original site: A0A0V1LR36_9BILA 
ID   A0A0V1LR36_9BILA        Unreviewed;      1945 AA.
AC   A0A0V1LR36;
DT   16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT   16-MAR-2016, sequence version 1.
DT   24-JAN-2024, entry version 31.
DE   SubName: Full=Cullin-4A {ECO:0000313|EMBL:KRZ61957.1};
GN   Name=CUL4A {ECO:0000313|EMBL:KRZ61957.1};
GN   ORFNames=T02_8348 {ECO:0000313|EMBL:KRZ61957.1};
OS   Trichinella nativa.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC   Trichinellida; Trichinellidae; Trichinella.
OX   NCBI_TaxID=6335 {ECO:0000313|EMBL:KRZ61957.1, ECO:0000313|Proteomes:UP000054721};
RN   [1] {ECO:0000313|EMBL:KRZ61957.1, ECO:0000313|Proteomes:UP000054721}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISS10 {ECO:0000313|EMBL:KRZ61957.1};
RA   Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT   "Evolution of Trichinella species and genotypes.";
RL   Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:190135;
CC         Evidence={ECO:0000256|ARBA:ARBA00034078};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor Fz/Smo family.
CC       {ECO:0000256|ARBA:ARBA00008077}.
CC   -!- SIMILARITY: Belongs to the complex I 24 kDa subunit family.
CC       {ECO:0000256|ARBA:ARBA00010643}.
CC   -!- SIMILARITY: Belongs to the cullin family.
CC       {ECO:0000256|ARBA:ARBA00006019, ECO:0000256|PROSITE-ProRule:PRU00330,
CC       ECO:0000256|RuleBase:RU003829}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KRZ61957.1}.
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DR   EMBL; JYDW01000013; KRZ61957.1; -; Genomic_DNA.
DR   Proteomes; UP000054721; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR   GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR   GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR   CDD; cd03064; TRX_Fd_NuoE; 1.
DR   Gene3D; 1.20.1310.10; Cullin Repeats; 4.
DR   Gene3D; 1.10.2000.10; Frizzled cysteine-rich domain; 1.
DR   Gene3D; 3.40.30.10; Glutaredoxin; 1.
DR   Gene3D; 1.10.10.1590; NADH-quinone oxidoreductase subunit E; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR045093; Cullin.
DR   InterPro; IPR016158; Cullin_homology.
DR   InterPro; IPR036317; Cullin_homology_sf.
DR   InterPro; IPR001373; Cullin_N.
DR   InterPro; IPR019559; Cullin_neddylation_domain.
DR   InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR   InterPro; IPR000539; Frizzled/Smoothened_7TM.
DR   InterPro; IPR036790; Frizzled_dom_sf.
DR   InterPro; IPR017981; GPCR_2-like_7TM.
DR   InterPro; IPR002023; NuoE-like.
DR   InterPro; IPR042128; NuoE_dom.
DR   InterPro; IPR041921; NuoE_N.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   NCBIfam; TIGR01958; nuoE_fam; 1.
DR   PANTHER; PTHR11932; CULLIN; 1.
DR   PANTHER; PTHR11932:SF123; CULLIN 4, ISOFORM A; 1.
DR   Pfam; PF01257; 2Fe-2S_thioredx; 1.
DR   Pfam; PF00888; Cullin; 1.
DR   Pfam; PF10557; Cullin_Nedd8; 1.
DR   Pfam; PF01534; Frizzled; 1.
DR   SMART; SM00182; CULLIN; 1.
DR   SMART; SM00884; Cullin_Nedd8; 1.
DR   SMART; SM01330; Frizzled; 1.
DR   SUPFAM; SSF75632; Cullin homology domain; 1.
DR   SUPFAM; SSF74788; Cullin repeat-like; 1.
DR   SUPFAM; SSF63501; Frizzled cysteine-rich domain; 1.
DR   SUPFAM; SSF52833; Thioredoxin-like; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS01099; COMPLEX1_24K; 1.
DR   PROSITE; PS50069; CULLIN_2; 1.
DR   PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE   3: Inferred from homology;
KW   2Fe-2S {ECO:0000256|ARBA:ARBA00022714};
KW   Iron {ECO:0000256|ARBA:ARBA00023004};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW   Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054721};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        216..237
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        249..269
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        289..318
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        338..363
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        383..403
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        424..445
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          214..405
FT                   /note="G-protein coupled receptors family 2 profile 2"
FT                   /evidence="ECO:0000259|PROSITE:PS50261"
FT   DOMAIN          1582..1818
FT                   /note="Cullin family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50069"
FT   REGION          749..775
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          804..831
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        813..831
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1945 AA;  221802 MW;  3864971B619C07F3 CRC64;
     MRMQTYLSIA LLHLQKRLFP VDIVQQYKGG GQRFFFTNSW LNDPLCWRST TEKCLTHDKE
     LKCFGETLAT KEVYPLSIIT NANTSGYENF YRLSHCWPYL KEMLCSAMMA PCKNSRVRLI
     SESLCIETRD QCQFLIKHGR WPKILSNCRD SKLYSRDCKQ SLQPLFRHEN ISTNRASCLL
     PLVYSEHRDQ LHFPNCAFNC TSHWLKPQEH EELDSVVLFL SPIICTFLIL TLIATVTGVR
     RIPKDFYPLA WKIFCHAVIA LVIAFRFKFK YLVSCNSDGS LRSKDQKHFR SSICTLQFVC
     LYLSTLASSG WLTVFFAFQL AETLPSSSDF SHSVYDKLIN NVHFALWGPC LLLVITVISS
     MSYGPDGING MCYFGVDDPM NNFYLVYLPT GIALIMTTTF FVITVARRHH ISRAANTVAS
     QRRLWYGFST AKLGILFATN LLLYVTDLGF HIYDMSMFYK RNTALVDFFL CQLDHPYPSL
     HCKLMHTLNI ALVKVGFLVQ FLFPGLIDCA FLWLQSRYEL DREAWLQLFR EKIGMIRNRS
     KMHGNRKGNL NNDCKDECEL HSLQSAMDVQ ITTNRYARTT PLNSASGSAV DVGTQSDSEL
     LTRHRSKREF IERFRKRSDM RYLRKHEAPS SSLSRTPSSL RSCLLPTPLR VLSAPGMPFS
     TSSLQSLPAE GAAVPDAGAC AATWNPYYPY LQFYPAPFNN SVWTNVMQAG CQFTVPQPAA
     HGLPHFTYPV CVNPAWFNGV AAVASGAKST EPGVACPTES APPAPSASAA SGTTKTDVPV
     QAASCRVAES STCDQKKMEK SRQISAAAAA AASADDDEDE EPWDDSDFDS EEEEFVERQL
     LAMKAQQQQS PSALKEQNYL FLHFQQMLSA MVLCRSWLVG RLQWAAVRRS HDQLFVHRDT
     PDNNADVPFE FSEENMKRVE AIKALYPVGY TSAAILPVLD LAQRQHGWLP ISAMNKVADV
     IGVPKMRIYE VATFYTMYNR QKVGKYHVQV CTTTPCMLRG ADQILKHVKK ECLGSDAVGE
     TSQDFMFTVS EVECLGACAN APMMQINDDY YEDLTYDDVT RIFGEIRAGK KPKMGPQSGR
     LAAEPISGLT SLTSTPYGPD KFGDSGEKKN TLIIPMETYV ILENYFYKKS RNCIWGRVIV
     SSVVVSGIHL GDILKLSAYF SLKMSSLISI NRETRSDGSR SAKQSKFLTP PNRSETVRWT
     DNVRHHQPGN IPLTFQSDCC KWLNTNQSIC LMEEQLECKW KKLEEPVWAI LMQKSYKNST
     EDLFSTVDEI VRFIGKSKWL YEKLFTFCEV CVSKRSAVLM EGNLDALSFS KLVMKIWQEH
     CSQMKSIRLI FSQLDRSAAL QEMPMMSIWE MGLTIFRSCA IMRSSIQTKL VDSLLFLIHQ
     ERSGEDVDHL LIRNLLHMFA TLNIYREILE VRLLEETKTF YLEEGMRRIE VDDVPHYLAY
     VTKQLKLESE RTEFYLDKNS GKSLISVVED GLISPHVEDI LNKGFDCMLY NSQLDDLKLL
     YQLISYDPAN IDELKMRFSN YISVNVMSFL KGDEIDCEAL RSLLKYRDFV SNVVSYCFSD
     SAGIDLAARS VFSSIVNKKS AKVNELLAKF IDMKLRTGRK QYPEEELDQE TVKALSLFRI
     VDGKDLFEMF YQKFLAKRLL FGKSASFDAE KAVLSELKRE CGSDFTSKLE VMFRDFETSK
     EFASGFKNYL TASNCLNSVV EMNVSVLTIG NWPSYPKMDI IYPQVLLSSM SQFEHFYMEK
     HAGRKLSWQS YVGQCLVAAR FKPGVRCTLF VEKELQVSLF QGIVLLLFND SDQLSFKSIQ
     QQTNIETVEL RRTLQSLACG KFRVIQKVPK GKDVNENDTF IFNANFTSPM LRIKINQIQS
     KETNEENFMT VEQVNSNRVF SIDAAIVRIL KTRKTISHSE LMSEIVRQLQ FSVQASDVKK
     RIENLIERRF ISRDVKNSSN YNYIS
//
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