ID A0A0V1LT45_9BILA Unreviewed; 2422 AA.
AC A0A0V1LT45;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=5'-3' exoribonuclease 1 {ECO:0000313|EMBL:KRZ62519.1};
GN Name=rpl-12 {ECO:0000313|EMBL:KRZ62519.1};
GN ORFNames=T02_6871 {ECO:0000313|EMBL:KRZ62519.1};
OS Trichinella nativa.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6335 {ECO:0000313|EMBL:KRZ62519.1, ECO:0000313|Proteomes:UP000054721};
RN [1] {ECO:0000313|EMBL:KRZ62519.1, ECO:0000313|Proteomes:UP000054721}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS10 {ECO:0000313|EMBL:KRZ62519.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ62519.1}.
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DR EMBL; JYDW01000008; KRZ62519.1; -; Genomic_DNA.
DR STRING; 6335.A0A0V1LT45; -.
DR Proteomes; UP000054721; Unassembled WGS sequence.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR CDD; cd18673; PIN_XRN1-2-like; 1.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 1.25.40.1050; -; 1.
DR Gene3D; 2.170.260.40; -; 1.
DR Gene3D; 2.30.30.750; -; 1.
DR Gene3D; 3.40.50.12390; -; 2.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR027073; 5_3_exoribonuclease.
DR InterPro; IPR006595; CTLH_C.
DR InterPro; IPR006594; LisH.
DR InterPro; IPR041385; SH3_12.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR InterPro; IPR040992; XRN1_D1.
DR InterPro; IPR047007; XRN1_D1_sf.
DR InterPro; IPR041106; XRN1_D2_D3.
DR InterPro; IPR041412; Xrn1_helical.
DR InterPro; IPR004859; Xrn1_N.
DR InterPro; IPR047008; XRN1_SH3_sf.
DR PANTHER; PTHR12341:SF41; 5'-3' EXORIBONUCLEASE 1; 1.
DR PANTHER; PTHR12341; 5'->3' EXORIBONUCLEASE; 1.
DR Pfam; PF18129; SH3_12; 1.
DR Pfam; PF00400; WD40; 3.
DR Pfam; PF18332; XRN1_D1; 1.
DR Pfam; PF18334; XRN1_D2_D3; 1.
DR Pfam; PF17846; XRN_M; 1.
DR Pfam; PF03159; XRN_N; 1.
DR SMART; SM00667; LisH; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50897; CTLH; 1.
DR PROSITE; PS50896; LISH; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 4: Predicted;
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Reference proteome {ECO:0000313|Proteomes:UP000054721};
KW WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT DOMAIN 1898..1957
FT /note="CTLH"
FT /evidence="ECO:0000259|PROSITE:PS50897"
FT REPEAT 2079..2120
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 2340..2372
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 1276..1338
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1356..1404
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1417..1504
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1749..1779
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1276..1299
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1300..1317
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1318..1338
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1356..1397
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1440..1465
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1466..1481
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2422 AA; 273815 MW; 24A3510AA18C1125 CRC64;
MGVPRFFRWL SERYPGLSQL VVESQIPSYD NLYLDFNGII HNCSHPSFAD ATFRCTEVDI
FTNIFSYIEG IFQLIKPRKL LFIAVDGVAP RAKMNQQRSR RFMSAKEAED SRLKAIRNGE
VIPDSDPFDS NCITPGTEFM ERLHIHLKYF INLKLSSDPL WQNVDVYYSG HDCPGEGEHK
ILAFIRFMRS QADYDSNTTH CIHGLDADLI FLGMAMHEPY FSILREEVVP FRRSKKGLRM
VEDQKFYLLH LILLREYICL EFEHLKQVKP DVYDEEKIID DWIFMSFFIG NDFIPNVPML
ITNENALPNV WLAYQNAFPN MDGYLNNGGH LNIPNLKIFF NELKKFEYQK YENHLKACGW
LESKRAQRDA QQQSHRKDFS ATSTSLEITS FSSQSETANG SSDSCVLQSV VAFSEKLPDT
CSCALENDDG SLFDDDDDDD SEDAVDMRSE TCDGLCGVSV LTEEESDMSL HSLFRKYRAS
SALQNVITNY VEALQWILYY YFHGVPSWKW FYGFHYAPFA SDLCDFNVEE ISFELGEPFL
PFQQMLAVLP PSSRKLLPEP YQDLMVNPDS PLSYAYPEDV ERDMNGKRYE WECILKLPFI
DEEILFVAVY PFNDALKDDE KRRNRFGKCY LYRYSGSHGE RRTTTYRSSL PDVFPDIESC
TCECTELPID HFELNETLIK YGRLQRNEEV GSKQICFPTF SFHDLKIKLN KAEVDGPLSL
KLCSSFNMTF SDAAALYLGK RILFSWPYSI IGLCVKVSTM DCNCAVLDED GNCNITYVEH
DGNAKIMWKR MAKICEEQYL DKFGIKMKVK ILLHYKLISG WKHVLNNNGN FELIPFWSDK
EAETPVQLVL PEFVIDDKYF TERPIEKFAP FASYAFSLHR KCYGAMCQIL EYGTNMRLSV
SLRRFPAVRF NITLDMMEET LANWYSTREL IEMFQLLPST LGRLTGSLLI AKNKDLERKV
NIGLNLKSNQ KSAEKLGYAM RIDGKRWIYS EDAVKLIEGY IQEFPDIIAY LEMNDFDALR
RMLAWLKNLP SASATFVPFG TKFVNSDDIK FIEREVEKLT QDTYEDGWNM DSNSLFFPLL
CCGPIAADPE TDFQLFDRVI NVRAGCCVPY GMAGTVINLP GGASHPKGNL EVLFDRPFVG
GMSIRGSKPS AFRLPSYALV NFTYSQRKKK QRCLANKTKT GESSANELFP TGGISFFRST
AHPAVRHLDK KPTTSTNSSA FLNSKEAHTL MHCGRGSYGV DVFNSRAGST SFISPTHATE
QIKQCLGLNQ VEDTNCKQQD RPVASSSSTA SNHGNRIKKT VSQPHYRHQH WQRHHHQQRQ
QQQQQQQQQR DDDFSNSGLL IDSSVLSSML MEGGKKSIAQ TTTTTTTTTA TKELHKSPVN
LPTTHSAKET TIPTKSTPKP YYFRPTDRYA SLQWNNEASA RSSSQRHHTS SHRNNQPNRR
KVRKVDEIAA LLKRLLEDPE DTTSQRQPSK SDSSVGSAQL SGAKQDRIPR DGDMERGQQQ
AASLHEHGDE FIYALNQLIM SGGQLERQQQ QQQKQPQHQT DIAVQLAQMG IEICQAEKQN
EQNVVVIRSI SEMNQCEILA ECSDDESYSG AKVSDSRAWI PDQETAKELL EKIKQGGYGE
LPKLESTLPS STVNLPPNPP GRSNHVCRLA KFTFLSIIVF SVWIGFGQDQ IIITVVCIYT
VFLTFSSLVK CNRRILLHYC IVYEQGVVSR GCCLSLDASG DLDTCCCVES EESVCSTVDL
DPTRAVEGTS AASEARAVPS AGPSTGHCPS SPPPVKRPRM QDHLQVDVSA STACSTTAGV
IPSPSSCHAA SPNSASMTNT ITCRLKKLVH ACNGTSPQNR ENRPAAWSSQ HGLLKSAGHS
RLPDADQELI RIVAQYLRNM GFSETVKVLS LESGCSMENP LATKLREYVF RGHWNRALRT
LYDLKVFIEK EEDFVEMQFM LLQQKFLSLV EKGRVLHALK LLRDKMSILK VDRAKLNALS
YFVMANSADV VKHPDYTGGS VSARENLMNE LQNFLPTTLM LPPQRLQALI KQSLELQRLR
CRFHNRRDTS PCLDISNNSL LSDHTCKKTD FPCQTVQVLL DHCDEVWYCQ FSHAGKLLAT
GSKEGVIYIW DVNLSSRSVT KKFTLDGHSF GAAYFVFSPN DKYLACVGPE DSPDLWIWDT
ETGILRIKIT HSPDDSISCV SWHPDGTKVV CGGTKGQFYQ CDLEGTVVDS WEGVRVRSIQ
YRKDGRTVLA ADTHHRIRSY CFDDLTDKTV IKEDHSLMHF SIDKSEHFAL CSVANQGVHL
WDLESGSLVR RYRGVVQGYF NIFSCFGGVD EKYVASGSEE VSVGKVYIWH RDEEAPVVVL
SGHSSVVNAV SWNPAEPSLL ASCSDDGSVR IWGPHECCSN PESCSLCRVG IAEDDNEVLN
CHPGVAATAT ITTTLSLSAR LL
//
