ID A0A0V1LUP0_9BILA Unreviewed; 933 AA.
AC A0A0V1LUP0;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Staphylococcal nuclease domain-containing protein {ECO:0000256|PIRNR:PIRNR017179};
DE EC=3.1.31.1 {ECO:0000256|PIRNR:PIRNR017179};
GN Name=SND1 {ECO:0000313|EMBL:KRZ63231.1};
GN ORFNames=T02_8175 {ECO:0000313|EMBL:KRZ63231.1};
OS Trichinella nativa.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=6335 {ECO:0000313|EMBL:KRZ63231.1, ECO:0000313|Proteomes:UP000054721};
RN [1] {ECO:0000313|EMBL:KRZ63231.1, ECO:0000313|Proteomes:UP000054721}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS10 {ECO:0000313|EMBL:KRZ63231.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Endonuclease that mediates miRNA decay of both protein-free
CC and AGO2-loaded miRNAs. {ECO:0000256|PIRNR:PIRNR017179}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-
CC phosphooligonucleotide end-products.; EC=3.1.31.1;
CC Evidence={ECO:0000256|PIRNR:PIRNR017179};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|PIRNR:PIRNR017179}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ63231.1}.
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DR EMBL; JYDW01000002; KRZ63231.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V1LUP0; -.
DR Proteomes; UP000054721; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016442; C:RISC complex; IEA:UniProtKB-UniRule.
DR GO; GO:0016894; F:endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters; IEA:UniProtKB-EC.
DR GO; GO:0004521; F:RNA endonuclease activity; IEA:UniProtKB-UniRule.
DR GO; GO:0031047; P:regulatory ncRNA-mediated gene silencing; IEA:InterPro.
DR CDD; cd00175; SNc; 2.
DR CDD; cd20433; Tudor_TDRD11; 1.
DR Gene3D; 2.30.30.140; -; 1.
DR Gene3D; 2.40.50.90; -; 5.
DR InterPro; IPR016685; Silence_cplx_Nase-comp_TudorSN.
DR InterPro; IPR035437; SNase_OB-fold_sf.
DR InterPro; IPR016071; Staphylococal_nuclease_OB-fold.
DR InterPro; IPR002999; Tudor.
DR InterPro; IPR047386; Tudor_TDRD11.
DR PANTHER; PTHR12302; EBNA2 BINDING PROTEIN P100; 1.
DR PANTHER; PTHR12302:SF2; STAPHYLOCOCCAL NUCLEASE DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00565; SNase; 5.
DR Pfam; PF00567; TUDOR; 1.
DR PIRSF; PIRSF017179; RISC-Tudor-SN; 1.
DR SMART; SM00318; SNc; 4.
DR SMART; SM00333; TUDOR; 1.
DR SUPFAM; SSF50199; Staphylococcal nuclease; 5.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 1.
DR PROSITE; PS50830; TNASE_3; 4.
DR PROSITE; PS50304; TUDOR; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|PIRNR:PIRNR017179};
KW Reference proteome {ECO:0000313|Proteomes:UP000054721};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 20..168
FT /note="TNase-like"
FT /evidence="ECO:0000259|PROSITE:PS50830"
FT DOMAIN 195..331
FT /note="TNase-like"
FT /evidence="ECO:0000259|PROSITE:PS50830"
FT DOMAIN 343..495
FT /note="TNase-like"
FT /evidence="ECO:0000259|PROSITE:PS50830"
FT DOMAIN 541..679
FT /note="TNase-like"
FT /evidence="ECO:0000259|PROSITE:PS50830"
FT DOMAIN 762..820
FT /note="Tudor"
FT /evidence="ECO:0000259|PROSITE:PS50304"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 933 AA; 104450 MW; 8D885622E7F172F2 CRC64;
MYPNNVSSQT PQPAPVSSPP LMRGIGKMAL GGDSIVIRGQ PKGGPPPERL INLSNVISPK
LARRQADSTA TDSQDEPYAW EAREALRKLV VGHELLFTVD YKVPTSGREY GSVFVTIDGK
RQNVAETLVS QGWLEVRQSG VKSNDDAVKR LLELQNTAKA NSKGKWQADD ATKHVRQIIW
STANPRSLVE SFNRSRIKAV IEHVRDGCTV RAFLLPSFHY VTIMISGIRT PTFKLGEGGM
IQDPEPFAEE AKFFTECRLL QNDVEVILEG ASNQNFLGTV LHKHGNIAEA LLKEGFAKCV
DWSMPLVTSG PEKLREAERQ AKERRLRLWK NYEPSHAKAA GENSFQAKVV EITLGDSMII
KKQDGMYQKI FLSSIRPPRL EDAGLVRETQ SGRQFRPLYD IPFMFAAREV LRKKLIGKKV
NVTIDYVQPS VNQLPERTCC TVVFGGQNMA ELLVSKGLAA VVRNRQGDEN RSPFYDNLLT
AEAAAEKARL GIHSLKHSVD ANHMETANIY NTSEKQIVRL QELQGNVAKS KQFLPFLIRS
GRTDGLVEFV VTGSRLRIFV PKESIMITLL LGGVSCPRPG RMTKGGGAAE AEDEPFSQEA
LQFTKDFCLQ REVEFEVESV DKAGNFIGWC FFHGKNLSEL LVENGLAAVH FTADRSKYGP
ALRAAELRAK EAKLKIWTLA YYDDETEELN DADDLDKGPS AAPSAGIVPE RVPQYRAVLV
TEICENLKFY IQYFDQGSQL EQMMKEMRTA LNADPGRQGA FVPKKGDVCA ALFSADQQWY
RARVEAVRKD EIDVFYIDFG NRETRKQNEL ASLPAGFASR PPGARECAFA LLKLPDDADY
CTAAVKHFYK EVNGEQCLMN MEYRLGGVEY VTLLRADQSD IGKSLIRNGY CLVEQRRDRK
MQLQLADYLQ AQESAKSERL NIWQYGDFTG NEL
//
