ID   A0A0V1LVS6_9BILA        Unreviewed;       524 AA.
AC   A0A0V1LVS6;
DT   16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT   16-MAR-2016, sequence version 1.
DT   27-MAR-2024, entry version 11.
DE   SubName: Full=Hormone-sensitive lipase {ECO:0000313|EMBL:KRZ63500.1};
GN   Name=Lipe {ECO:0000313|EMBL:KRZ63500.1};
GN   ORFNames=T02_11813 {ECO:0000313|EMBL:KRZ63500.1};
OS   Trichinella nativa.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC   Trichinellida; Trichinellidae; Trichinella.
OX   NCBI_TaxID=6335 {ECO:0000313|EMBL:KRZ63500.1, ECO:0000313|Proteomes:UP000054721};
RN   [1] {ECO:0000313|EMBL:KRZ63500.1, ECO:0000313|Proteomes:UP000054721}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISS10 {ECO:0000313|EMBL:KRZ63500.1};
RA   Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT   "Evolution of Trichinella species and genotypes.";
RL   Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KRZ63500.1}.
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DR   EMBL; JYDW01000001; KRZ63500.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0V1LVS6; -.
DR   Proteomes; UP000054721; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016298; F:lipase activity; IEA:InterPro.
DR   GO; GO:0008203; P:cholesterol metabolic process; IEA:InterPro.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:InterPro.
DR   InterPro; IPR010468; HSL_N.
DR   InterPro; IPR045325; TMEM70/TMEM186/TMEM223.
DR   PANTHER; PTHR23025:SF3; HORMONE-SENSITIVE LIPASE; 1.
DR   PANTHER; PTHR23025; TRIACYLGLYCEROL LIPASE; 1.
DR   Pfam; PF06350; HSL_N; 1.
DR   Pfam; PF06979; TMEM70; 1.
PE   4: Predicted;
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054721};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        81..98
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        110..133
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          222..508
FT                   /note="Hormone-sensitive lipase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF06350"
SQ   SEQUENCE   524 AA;  60489 MW;  C258E52E79F643F2 CRC64;
     MAAIANAIFV SRRFKSIRVM NVWYVALKFR PALPIYHMNA MLKTSCLNSN KYPFNKGERE
     SLGKLVYSSG SMKNLIRGVK LFSLLTTTVA FAMQPMIWHD MFVHDDRSAL LTTLTLSFLS
     FSVMCSPLLL NLLTKRYVIC MYHDEKQQLF SVMTYNIFAW PRIIQFKFED IKAFDSPILA
     NLLVDSYPLL MMSTNFTDQY VLEKFLPLLG EEEETPKRKV DDDEDGVSFE KHICAAMNSL
     QEVKSSLHPI CMAMSRFDYD ISIVGNGYRS IVTVFDLCLI GLLRSLFKIS KISHRRWFRA
     SRPVKEVIAY AEILRVLCQA VDLVSKYLPK PNSHCLFLTN VDADDLDRLM SSFEQLDQSN
     FYGRQIGFQF CSSVSNVFHV IGTALASYST LWNHSNVWYR RYPSIVYSCC RFLVNPENRS
     KHIAKIFRHS DLELCRSFWS LLESPILRTL PSVVGPKLAV NELYCIQPTD MLSLEKKNGT
     MVNIPVPSAF SGPRNLCVRI LSLHRWPGLV KFFTPTRWRS YNFR
//