ID A0A0V1MD85_9BILA Unreviewed; 397 AA.
AC A0A0V1MD85;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=Eukaryotic translation initiation factor 2A {ECO:0000256|ARBA:ARBA00013819};
GN Name=EIF2A {ECO:0000313|EMBL:KRZ69751.1};
GN ORFNames=T10_9276 {ECO:0000313|EMBL:KRZ69751.1};
OS Trichinella papuae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=268474 {ECO:0000313|EMBL:KRZ69751.1, ECO:0000313|Proteomes:UP000054843};
RN [1] {ECO:0000313|EMBL:KRZ69751.1, ECO:0000313|Proteomes:UP000054843}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS1980 {ECO:0000313|EMBL:KRZ69751.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Functions in the early steps of protein synthesis of a small
CC number of specific mRNAs. Acts by directing the binding of methionyl-
CC tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it
CC binds methionyl-tRNAi to 40S subunits in a codon-dependent manner,
CC whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a
CC GTP-dependent manner. {ECO:0000256|ARBA:ARBA00003993}.
CC -!- SIMILARITY: Belongs to the WD repeat EIF2A family.
CC {ECO:0000256|ARBA:ARBA00009573}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ69751.1}.
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DR EMBL; JYDO01000129; KRZ69751.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V1MD85; -.
DR Proteomes; UP000054843; Unassembled WGS sequence.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR011387; TIF2A.
DR InterPro; IPR013979; TIF_beta_prop-like.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR13227; EUKARYOTIC TRANSLATION INITIATION FACTOR 2A; 1.
DR PANTHER; PTHR13227:SF0; EUKARYOTIC TRANSLATION INITIATION FACTOR 2A; 1.
DR Pfam; PF08662; eIF2A; 1.
DR SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
PE 3: Inferred from homology;
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540,
KW ECO:0000313|EMBL:KRZ69751.1};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000054843};
KW Translation regulation {ECO:0000256|ARBA:ARBA00022845};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574}.
FT DOMAIN 274..385
FT /note="Translation initiation factor beta propellor-like"
FT /evidence="ECO:0000259|Pfam:PF08662"
FT REGION 31..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 397 AA; 45083 MW; 0ACA091AE81B0E99 CRC64;
MRPLTERAQF TNVMGFRTVF AVVEGEQERR VLQRRQDKPR SDKRLTDSKP MSTDAEKAEL
GHLPKFALRD DGNITVYAGI KNPVQVFTHE CRACISGATL TFSNDGKYFA FCDEKIYVFK
CSKWKLHAAF DENEATNLFF SPKTSVLCTF KPYSTAVGVT SVESNLKLWS MVTGKLLCEW
VQKNIVSWRP MWTADESIVA RLVGSELWFS APENLNRYIQ KLTLPKLSSF SLSPGPAPFH
VAVYTASSRE KMASARLYSC SLNWPIDIIA CKNFQADRVD FHWNKNGTAV LVMAILDVDP
QNKSYYGCEN LHLMTTCGVA CNVPLDREGP IHSVDWHPGS KLFCVVYGYI PSKAALFDLK
ANRVFDFGCE PRNEVHFNRF GNYILSWNNF IIFFSLS
//
