ID A0A0V1MDQ4_9BILA Unreviewed; 893 AA.
AC A0A0V1MDQ4;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=Macoilin {ECO:0000256|ARBA:ARBA00021882};
DE AltName: Full=Transmembrane protein 57 {ECO:0000256|ARBA:ARBA00031129};
GN Name=TMEM57 {ECO:0000313|EMBL:KRZ69786.1};
GN ORFNames=T10_5103 {ECO:0000313|EMBL:KRZ69786.1};
OS Trichinella papuae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=268474 {ECO:0000313|EMBL:KRZ69786.1, ECO:0000313|Proteomes:UP000054843};
RN [1] {ECO:0000313|EMBL:KRZ69786.1, ECO:0000313|Proteomes:UP000054843}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS1980 {ECO:0000313|EMBL:KRZ69786.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Plays a role in the regulation of neuronal activity.
CC {ECO:0000256|ARBA:ARBA00003440}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Nucleus membrane
CC {ECO:0000256|ARBA:ARBA00004232}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004232}. Rough endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004269}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004269}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ69786.1}.
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DR EMBL; JYDO01000128; KRZ69786.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V1MDQ4; -.
DR STRING; 268474.A0A0V1MDQ4; -.
DR Proteomes; UP000054843; Unassembled WGS sequence.
DR GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030867; C:rough endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0023041; P:neuronal signal transduction; IEA:InterPro.
DR InterPro; IPR019130; Macoilin.
DR PANTHER; PTHR47464; MACOILIN; 1.
DR PANTHER; PTHR47464:SF2; MACOILIN; 1.
DR Pfam; PF09726; Macoilin; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000054843};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..44
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 78..104
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 297..319
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 344..389
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 455..498
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 782..809
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 584..646
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 675..735
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 455..482
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 784..808
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 893 AA; 99860 MW; 35C5E896831E21B5 CRC64;
MKRRTTDNAK LRRAFKKNKM PESLCGSSLI YFKMILVWTV VMMADFMLEF RFEYFWPFWL
MLRCIYDSFR YQGMTFTVFF ICVTFTSDMI CFIFVPVQWV FFIASTYVWV QYVWHAADRG
ICLPTTTLWM IFLYVEASVR LKELKTLPLT LDLCRPLAAH CIGYPVVTLG FDVKSYVSYR
LRLTGIKAAV SVLNLLIRIF CIGEQRAKFA FKMESERRQK EISRTNQFYW SLLFFALPGD
KVSVSSEKCK GSVQVKEESG GSVRNGNIVE NGANPTTDGV NALQVALPKG TAQLIRGPVQ
STGGAQSKSR NSKQSTQPTV IDCETTLRNG GAFFSGGGGG GGVALVSSSA SRQRQNSSNQ
KQIRKRRAKL NKKANQNDPV PYQEEPSKDV EPQLTSWWSA GLRQICGSLD WLMASFGHYY
SGGVVACNDT DYADSETSSE NKDEHRKLVD YISTSTVSPA NKQANNSKLP TSSASCMAAD
RTGQNRKSRR KGGGVCGAST GPTVASAAGS GMDMVTVRDA IGSSGGTLAR IRTITDRDMS
VCCGCEADLE KMKLDLRTSK SREQELRLQL MEMSNVECSL KSELNELKIN NEQLQTRVQN
LLRSRQQDRQ VINGLEKKIA EEQKAKVHLD QQLQQERRAT KKAEETAAAL ISSRHQAAAS
AGSFRNGDCE QCRRRRDGEK ELKHARKELT QREEQIGKLE SEVRTLRLFK ESNTVEQLTA
TVTEMERKNA HLESSLSAET RIKLDLFSAL GESKRQHEIV LGQLDEQRKV IADLQRRLNE
FSNGVRHHGS TTQSPQNTVS SSMSPPPHNA HCNLAVRAGA AFITSEGHKM EHGVLLSPSP
PVYSPTYIAN VSPFGMEEPR CRSYPAPNMQ ARILNNKIGN FGSYRFKTHS PQL
//
