ID A0A0V1MDU5_9BILA Unreviewed; 1005 AA.
AC A0A0V1MDU5;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE SubName: Full=X-ray repair cross-complementing protein 5 {ECO:0000313|EMBL:KRZ70091.1};
GN Name=Xrcc5 {ECO:0000313|EMBL:KRZ70091.1};
GN ORFNames=T10_13569 {ECO:0000313|EMBL:KRZ70091.1};
OS Trichinella papuae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=268474 {ECO:0000313|EMBL:KRZ70091.1, ECO:0000313|Proteomes:UP000054843};
RN [1] {ECO:0000313|EMBL:KRZ70091.1, ECO:0000313|Proteomes:UP000054843}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS1980 {ECO:0000313|EMBL:KRZ70091.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the ku80 family.
CC {ECO:0000256|ARBA:ARBA00007726}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ70091.1}.
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DR EMBL; JYDO01000121; KRZ70091.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V1MDU5; -.
DR STRING; 268474.A0A0V1MDU5; -.
DR Proteomes; UP000054843; Unassembled WGS sequence.
DR GO; GO:0043564; C:Ku70:Ku80 complex; IEA:InterPro.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0042162; F:telomeric DNA binding; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:InterPro.
DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; IEA:InterPro.
DR GO; GO:0000723; P:telomere maintenance; IEA:InterPro.
DR CDD; cd00873; KU80; 1.
DR Gene3D; 1.10.1600.10; -; 1.
DR Gene3D; 2.40.290.10; -; 1.
DR Gene3D; 1.25.40.240; Ku, C-terminal domain; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR006164; Ku70/Ku80_beta-barrel_dom.
DR InterPro; IPR024193; Ku80.
DR InterPro; IPR036494; Ku_C_sf.
DR InterPro; IPR005161; Ku_N.
DR InterPro; IPR014893; Ku_PK_bind.
DR InterPro; IPR019174; NADH_DH_b-subcmplx_su6.
DR InterPro; IPR016194; SPOC-like_C_dom_sf.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR12604; KU AUTOANTIGEN DNA HELICASE; 1.
DR PANTHER; PTHR12604:SF4; X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 5; 1.
DR Pfam; PF02735; Ku; 1.
DR Pfam; PF03731; Ku_N; 1.
DR Pfam; PF08785; Ku_PK_bind; 1.
DR Pfam; PF09782; NDUF_B6; 1.
DR SMART; SM00559; Ku78; 1.
DR SUPFAM; SSF101420; C-terminal domain of Ku80; 1.
DR SUPFAM; SSF100939; SPOC domain-like; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000054843}.
FT DOMAIN 554..694
FT /note="Ku"
FT /evidence="ECO:0000259|SMART:SM00559"
FT REGION 1..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8..39
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1005 AA; 114651 MW; 141821FD63DE02C7 CRC64;
MDNGKKSTGS SDETLNTPAD TATAGKPLKI VSSSSGHGPK KSYGPWELSF VDTPNSFFYR
PPESKSDAPS HIPSNPMNLE LHMKNERNRV VGLTPEEIEW RKKWVLDQKL HPDEPVYVES
AVMHLNPIRR LYRYPWDSLE RKVLIPALGL KKGHLVRTVV PKFFIGMLMT LYIYYHMKYN
KPNWLNRIRS YHHFPRSFIR NQDLIERDYP GLLDKAFPIP KEPKDFYDLN FSRRVTHLDV
GPPTLNIFPA VCTDDKKKAI MKEAVAICVD IGLGMRNETA ARGHCLLGTV LRCVQWIVQR
RIFSESKDEL ALILYNTADS KNPLSDIGKN KYSNISLINN FQVSSWELFS SLNSIETTSP
ALNSVDFLKV LEVCIHCIDE ETSNKRFQQK SIVLFSSFDA EIINKDDMDN VTKAIKQHQL
ELAFISCNND LCASNMEEDN YPKAWKFAKE FITAVDGIYC SLNDALNMLG SFQRRSIRSV
PWKCDLEFGT ILQIPICMYL KCKCYKLNQT WKWAFAENPY VDVKLERAYV RSCDEEDESL
NEEISSTASN IWSGVEVDSS YLVKAFRFGS SVVPLNKFDL NEAKYKDREK CFKVLGFFDR
CMVKQWQFAG DSTHFVFGDP KNAAACQAFS ALIHSCKSTS KVILVRYAYN VASNPRIGVL
IPLLNDTYEC FVFVILPFEE DLVIVDQKSI GEFEKCHVTD EQLEAVDKLI DAMNMTDLSS
SASSSGDATF KWSKVKNPYY QNLFRCMTFR ALQPKEKLPI LRDDLLKDVQ PDVALLDNAK
SALDLMRKNF ILEKVENTKG KRTAAEVFKN ELSDAFPAKI ASFQAIDEKI VTMKVGTVNP
VQDFIEISSQ IGKNQISEGN KFVCLFVCLF VYFHDNCRCI CSVCEQMKNV ILAFVQESND
DIFHDKALHC CAVLRPVCIK QSLPDLYNTI LRQAKCELVL GKQKNFWLLL KNKKDSLGLI
TVDECQSSSI SQEDAVSFYS EEVSDEILKN NPQLLDSTDL IDELE
//
