ID A0A0V1MEK8_9BILA Unreviewed; 942 AA.
AC A0A0V1MEK8;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 22-FEB-2023, entry version 28.
DE SubName: Full=Ral guanine nucleotide dissociation stimulator-like 1 {ECO:0000313|EMBL:KRZ69999.1};
GN Name=Rgl1 {ECO:0000313|EMBL:KRZ69999.1};
GN ORFNames=T10_1897 {ECO:0000313|EMBL:KRZ69999.1};
OS Trichinella papuae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=268474 {ECO:0000313|EMBL:KRZ69999.1, ECO:0000313|Proteomes:UP000054843};
RN [1] {ECO:0000313|EMBL:KRZ69999.1, ECO:0000313|Proteomes:UP000054843}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS1980 {ECO:0000313|EMBL:KRZ69999.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ69999.1}.
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DR EMBL; JYDO01000123; KRZ69999.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V1MEK8; -.
DR STRING; 268474.A0A0V1MEK8; -.
DR Proteomes; UP000054843; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00153; RA_RalGDS_like; 1.
DR CDD; cd00155; RasGEF; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF312; RAL GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR-LIKE, ISOFORM E; 1.
DR Pfam; PF00788; RA; 1.
DR Pfam; PF00617; RasGEF; 1.
DR SMART; SM00314; RA; 1.
DR SMART; SM00147; RasGEF; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000054843}.
FT DOMAIN 77..205
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 234..504
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT DOMAIN 595..688
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT REGION 565..588
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 942 AA; 109344 MW; 3DE706D26639E89E CRC64;
MTSRYWGEEK QADVHYEVYL KKVCYHSDGR HWKSHQNAKL TNCAVAKSRL NVLRYNLFNG
WSDRDVDDDR LEWETIKIRV IKAATLQKWV LDMVLIEDDC ARGYLFELFF ETYRAVATPM
DVLRIILSDL KTLLNDNGRV RRAAQCQWKF QTWCTVLRRW LSRYPEDFDE YPKYTCLCEI
VEFSRKNNDV LDLLAEKATT MRISFMQNGL LSADMLDYVG NCTMSRHLDL THMDPLYIAE
QLTCIDADLF KRLICYQCQS YFWSRRFKSS SASDCVNTVR ATVDQFNALA RRVMSSVVYN
IHEKAYYRAK VICCWILVAQ ELRSLKNFNS LKAILSALQS EPVYRLRSAW SLVSGDMLDF
FQELSRVFGE DDNSAAIRSL LLKEGTSKTA VGVGAKTRRV KLKRYRRTAS CDMLEVRGTV
PYLGTFLTDL SMIDTAFSDF TSEGLINVDK RRREYDVIGQ VKLIQKNVKY YRIKMDPKFW
VWFRALPDLD EKLCYDLSCC IEPTKEECSI SCSKICSQLF SEDEFSNSSS GSPNRVTNRR
RCSQLLSAVK LLDRSIFYQP LKDDNESGTT TADSAHGSGA SSINKQRSPV DAGADCYIVR
VTLEKSLQGD VNYETLYKSV KLENCDRTRD LIKKALAKHN VNASADQFSI VQILPDGKQL
QLPEQANAFY AAANRMEKMT FMLKKRELGS TPSVQRSDSR MSSCLSRWSS TGTLAFFQLS
MLRRSYSFQQ TRPAFQRSRS LSISRSSSFV VNAPYTISRS DSTVFNRTPR SYLPFSSYKP
FVAPVYGVVH RAPRYSDRYP HVRYSGYGEE TPGLNIINYT STLKPSHYTQ SYKPFRQYID
NTLSMYHSNI KLSPSYGYTP PRYGTPYRTY VHHMDVDDAV DLYKKRCMTS SALVKYWLTP
TNSETRRRRE LREFEPLYQP SYYRMKNELP RPWRSFTHRL IF
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