ID A0A0V1MEX9_9BILA Unreviewed; 756 AA.
AC A0A0V1MEX9;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=DNA mismatch repair protein Msh2 {ECO:0000313|EMBL:KRZ70234.1};
GN Name=Msh2 {ECO:0000313|EMBL:KRZ70234.1};
GN ORFNames=T10_4077 {ECO:0000313|EMBL:KRZ70234.1};
OS Trichinella papuae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=268474 {ECO:0000313|EMBL:KRZ70234.1, ECO:0000313|Proteomes:UP000054843};
RN [1] {ECO:0000313|EMBL:KRZ70234.1, ECO:0000313|Proteomes:UP000054843}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS1980 {ECO:0000313|EMBL:KRZ70234.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ70234.1}.
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DR EMBL; JYDO01000118; KRZ70234.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V1MEX9; -.
DR Proteomes; UP000054843; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR Gene3D; 1.10.1420.10; -; 1.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR011184; DNA_mismatch_repair_Msh2.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361:SF35; DNA MISMATCH REPAIR PROTEIN MSH2; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF005813; MSH2; 3.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000054843}.
FT DOMAIN 632..648
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
SQ SEQUENCE 756 AA; 86592 MW; FE4F46F14C61AFAF CRC64;
MDKDLYGIFA KIIEGKSPTN ICMFDRTDYY FCIGDDAFYI AKEILKTVTI LKHILVEDIP
QQYITLNKNT FERVVRELLL VHLYRIEVYR CSSARSQDWE LSAKASPGYI REFENILTNC
EELQEQSRIL AFKITEETGN ICKLNVSMVC CDLFHHTFQI CDILDNDNLA NFKRILAQLR
PKECLTVDSS VTLNQMRKNI FSQIAIPVTT LKKSDFNSSN VLNDLDMLVK FKKGSHGFCG
SLPEMKMSDT ILQCFAGLIK YFGLMNDDCF LKQFQIQYFT PEKHLRVEWS AFESLNLFRF
GGEKSADNLY GILNHCQTAI GQRLLHEYLK MPLLDKNKID ERLDIVNLFV QNGEIRNILQ
QELLCRFPDL HRLCRKFVIK RAGLAEVYKV YSAVNCASDM LKVLDKLNTS VIKDNFTEPL
LMTLDDFQKF MEMVSMTIDL DYIARTGEYR VKPEFSQFLQ DLNNCMQNID QKMTSYLAKD
EKIIRNQKAV ELLDMQKGSV RFTDETLKRM NSEMMKAKDS YEEFQKRVVD ELVATVATYM
DPMKSLAQVV GHLDVMVSFA IASVNAPVQY TAMIIIMAQM GCFVPCQEAT ISILDAVFTR
IGASDNQYKG LSTFMTEMVE VSEILELPSE NSLIVIDELG RGTSTFDGLG IAWAVAETIA
TKVRAFCLFA SHFYEMTMMA SELFMVKNYQ ALATFSENNL VLLYKIKPGM CDRSYGINVA
EMVGFPEIVL KEAWKEARRL EAHGRGGIDE DGSDQQ
//
