ID A0A0V1MF23_9BILA Unreviewed; 734 AA.
AC A0A0V1MF23;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Inositol polyphosphate 5-phosphatase OCRL-1 {ECO:0000313|EMBL:KRZ70175.1};
DE Flags: Fragment;
GN Name=Ocrl {ECO:0000313|EMBL:KRZ70175.1};
GN ORFNames=T10_8027 {ECO:0000313|EMBL:KRZ70175.1};
OS Trichinella papuae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=268474 {ECO:0000313|EMBL:KRZ70175.1, ECO:0000313|Proteomes:UP000054843};
RN [1] {ECO:0000313|EMBL:KRZ70175.1, ECO:0000313|Proteomes:UP000054843}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS1980 {ECO:0000313|EMBL:KRZ70175.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, phagosome membrane
CC {ECO:0000256|ARBA:ARBA00004580}. Early endosome membrane
CC {ECO:0000256|ARBA:ARBA00004146}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004608}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ70175.1}.
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DR EMBL; JYDO01000119; KRZ70175.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V1MF23; -.
DR STRING; 268474.A0A0V1MF23; -.
DR Proteomes; UP000054843; Unassembled WGS sequence.
DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030670; C:phagocytic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016791; F:phosphatase activity; IEA:InterPro.
DR GO; GO:0046856; P:phosphatidylinositol dephosphorylation; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd04380; RhoGAP_OCRL1; 1.
DR Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR046985; IP5.
DR InterPro; IPR000300; IPPc.
DR InterPro; IPR048869; OCRL-1_2_ASH.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR047078; RhoGAP_OCRL1.
DR PANTHER; PTHR11200; INOSITOL 5-PHOSPHATASE; 1.
DR PANTHER; PTHR11200:SF299; PHOSPHOINOSITIDE 5-PHOSPHATASE; 1.
DR Pfam; PF03372; Exo_endo_phos; 1.
DR Pfam; PF21310; OCRL-like_ASH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00128; IPPc; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF56219; DNase I-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Reference proteome {ECO:0000313|Proteomes:UP000054843}.
FT DOMAIN 539..731
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KRZ70175.1"
SQ SEQUENCE 734 AA; 83662 MW; CA6390F110B80847 CRC64;
LPMNNNSQHN FLHFVEDHFG AQGNSYFESN TGRLDSRMAF LRNKFTGSCS SFTTHILQSK
ESEYCTYKTL KVFVSTFNVN GQPPEANLLD LFCQGIADPL PDIYAVGFQE LDLSQQTFLF
DITSREEEWA RVVLMNLKTV GDYVELKRVR LVGMFLVIYA TRELHQRDVI NEFATATVGT
GVLNRMGNKG GVAIRFRLYD SWLCFVNCHF AAGADELERR NQDFREISKT MFCDLANLGI
FDHDEIFWFG DMNYRLSEEG GRRTANAAFV KEACEIGLLE SLLHLDQLSR MKNIGLAFQE
FTEGKITFLP TYKYDIGTDT WDSSEKGRTP AWCDRILWCG DHIEQIAYES VPSVRMSDHK
PVRAIFSLQA KVVDSKKLQT LFEAALRESD RLENQWLPQV SLDKLEFEFK DVRFLEPLCQ
PLTITNIGRV PVYFEFRSES GQSVNCKPWL SITPDKYRIN INEKCVVDLQ VLIEKETVWK
MNSSGEKLDS ILVLHLDNGK DFFITVHAEY VPGCFGISLE KLYNTVQPGE CSSSAPKLID
MEEPAESADM KRSSSFPIPK EIWLLVDYIY KNGLDEENLF AQAGSHAEFI SIRNTLDAGS
GKQLSGSVRS VAETLLRFLD SLPEPLVPTD VYELCFRNVK DYGACKRAIA SFPALHNSVF
IYLICFLREV LHHSARNKTS ANGLAVIFAP ILFRFPEPAG RIFTRRATLM QKMQLATQFL
ETLFRGKEDD LIVL
//
