ID A0A0V1MJT9_9BILA Unreviewed; 2090 AA.
AC A0A0V1MJT9;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE SubName: Full=Voltage-dependent T-type calcium channel subunit alpha-1I {ECO:0000313|EMBL:KRZ72120.1};
DE Flags: Fragment;
GN Name=Cacna1h {ECO:0000313|EMBL:KRZ72120.1};
GN ORFNames=T10_2949 {ECO:0000313|EMBL:KRZ72120.1};
OS Trichinella papuae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=268474 {ECO:0000313|EMBL:KRZ72120.1, ECO:0000313|Proteomes:UP000054843};
RN [1] {ECO:0000313|EMBL:KRZ72120.1, ECO:0000313|Proteomes:UP000054843}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS1980 {ECO:0000313|EMBL:KRZ72120.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808}; Multi-
CC pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit (TC
CC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ72120.1}.
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DR EMBL; JYDO01000084; KRZ72120.1; -; Genomic_DNA.
DR STRING; 268474.A0A0V1MJT9; -.
DR Proteomes; UP000054843; Unassembled WGS sequence.
DR GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 5.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR002077; VDCCAlpha1.
DR InterPro; IPR043203; VGCC_Ca_Na.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10037:SF230; CA[2+]-CHANNEL PROTEIN ALPHA[[1]] SUBUNIT T, ISOFORM F; 1.
DR PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR Pfam; PF00520; Ion_trans; 5.
DR PRINTS; PR00167; CACHANNEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PIRSR:PIRSR602077-1};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673,
KW ECO:0000256|RuleBase:RU003808};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568,
KW ECO:0000256|RuleBase:RU003808}; Coiled coil {ECO:0000256|SAM:Coils};
KW Ion channel {ECO:0000256|RuleBase:RU003808};
KW Ion transport {ECO:0000256|ARBA:ARBA00022568,
KW ECO:0000256|RuleBase:RU003808};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR602077-1};
KW Reference proteome {ECO:0000313|Proteomes:UP000054843};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022568, ECO:0000256|RuleBase:RU003808};
KW Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT TRANSMEM 151..170
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 244..267
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 368..386
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 406..432
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 867..889
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 916..935
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1002..1025
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1425..1448
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1533..1552
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1633..1656
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1721..1742
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1754..1772
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1784..1802
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1851..1870
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1943..1965
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 111..438
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 747..926
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 929..1035
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1393..1665
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1719..1972
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 24..81
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 504..523
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 589..609
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1241..1261
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1974..1999
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1656..1700
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 504..519
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1978..1992
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 387
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT BINDING 984
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT BINDING 1605
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KRZ72120.1"
SQ SEQUENCE 2090 AA; 236958 MW; 84900FEDF6CB76AD CRC64;
LVKELKMWEG PLPAELRSFR SLSKVSRASI RRKSRSSVAA PPSPTGKFGE SSPGHNVDFG
RKRSASTATS DAPEHNNDHI QHIDDVEDVP YPAYVTTALR CLDQRTPIRY CMMVILINCI
TLGMYKPCDE DMELAICNTT RCITLSVIDH LVFAFFAVEM IIKIIAMGFY GPDTYMSDTW
NRLDFFIVIA GCAEYIFKER MGDINLTAIR TVRVLRPLRA INRIPSMRIL VNLLLDTLPM
LGNVLLLCFF VFFIFGIIGV QLWAGLLRNR CLLDLPSSND SSLELMGLVR YYMPDETSME
YICSLEKDNG MHSCNNLQPS TYNGHICNLT IDQWHAGNYT LSNSSCINWN QYYTKCGPTS
HNPFQGSVSF DNIGFAWVSI YLVISLEGWS DIMYYVQDAH SFWDWIYFVL LIVIGAFFMI
NLCLVVIATQ FADTKRRETE RMLAERARYP STSTLTTIDQ QSESDGVYRA IVKYIAHLGR
RAKRKAIRYY REWKKRRANV SEIPSPHLIT NSPKPAGSQE ADPSQICLVP KRPTYSSPCG
DSLTIPCNSP TGFYSRGSSV SYYSTLEDPG LTIPAADYLP YSPTRRYSSH RRSRLVRSAR
TSAGSADINK NGRKIKHHRL ASSKRYDPRF ALNYTESAPV CRPSVTGIRL RIHREASTSS
NSLSLDSEDE QTALYLDDES SNRDEMDLEL RKPYIDMDSE FDHDRVRFYT DQLHLRNKRQ
NSSSDLLVKC LAFLKVGIKR FVDSDHFTRG ILVAILINTL SMGVEYHNQP EELTVILEYS
NVFFTALFSI EMALKIIADG PFTYVSNGFN LFDGGIVILS IVELLQGGNG GLSVLRTFRL
LRILKLVRFM PALRYQLVVM LRTMDNVTVF FGLLCLFIFI FSILGMNLFG CKFCKQEVTA
DGEHVKSCDR KNFDSLFWAT LTVFQLEMLL SLLGMELFAG RFCQMPDGTP CHCKSKIPAC
KCPRRNFDTI INAAFTVFQI LTQEDWNVVL FNGMAQTSPW SALYFIALMT FGNYVLFNLL
VAILVEGFQE SKAEERRLMQ EEMDKTEIDP STKAKENTFE VYKSENEKGE KSAITCTCAA
GVAAATLLSS RSRDRLLSLP IMPVYVSGSE LVNAPPPIIQ TLPTPVGSPV MSSPSARNCR
KFGSKFDQNN NHSNGNSLYL PNSNAMSNST ISVKSHPLYK AGFHRDGQTK RKLTGQQSIT
YLDIPNPKSG SCLRRHWSSS SSTTTFYSCV NTNTESVATS SYKSLESSQQ EPVSVSTDAS
TNNQCNGSVM MQSEVEFSPR KVSSQLSQQI CSSVNPHIFY PYCRIHGYRL SLIGDGQKKE
ALLQSSPLFI HDEVNQLNVA SRQRKKSLKA QLVARFHQWF QQSWFQTRMD ASLFIFMPKN
KFRAQCVYLS QQKWFDFCIL TFIGINCITL AMERPGIPPN SFERLFLDIS GYIFTVIFAF
EMFIKVIAKS LVFGDGAYFK NGWDFMDGTL VLISLSNLIF DLLVKSHAPK IFSVVRVLRL
LRALRPLRVI NRAPGVKLVV QTLISSLQPI GNIVLICCTF FIIFGILGVQ LFKGKMWHCV
GPNVAKVINK TDCLADPHNR WINHRYNFDN LGQALMSLFV VSSKDGWVSI MYQGIDAVGV
DMQPVVNYFE WRMLYFISFL LLVGFFVLNM FVGVVVENFH RCKEALEKEM KEKEREKKMR
KRLQKQLSRQ QLLIKRSKKL PYWYHYGPVR MYLHGIVTSK YFDLAISAVI GVNVITMAME
FHMMPPELTY ALKVFNYFFT AIFTLEAILK VFALSIPRYL KDRWNQLDVI IVLLSIGGIV
LEEMESNILP INPTIMRVMR MLRIARVLKL LKMAKGIRSL LDTVMQALPQ VGNLGLLFFL
LFFIFAALGV ELFGRLECSD EHPCDGLGEH AHFKNFGMAF LTLFRIATGD NWNGIMKDTL
RDDCDNSENC TSNCCVSAII APVYFVVFVL MAQFVLVNVV VAVLMKHLEE SSKKMADGSS
EAGGSNATDT DEKSCTLRGD SDDERALHAV SSTTSLPTPQ DLSKIELPDN PVKFWIPDQS
ITQSDTLKKR NDKIDFDHQL DEMNSHCIKP CKNDRKCPVE KLHIDEEALF
//
