ID   A0A0V1MU89_9BILA        Unreviewed;       698 AA.
AC   A0A0V1MU89;
DT   16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT   16-MAR-2016, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   SubName: Full=Degenerin mec-10 {ECO:0000313|EMBL:KRZ75357.1};
DE   Flags: Fragment;
GN   Name=mec-4 {ECO:0000313|EMBL:KRZ75357.1};
GN   ORFNames=T10_2433 {ECO:0000313|EMBL:KRZ75357.1};
OS   Trichinella papuae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC   Trichinellida; Trichinellidae; Trichinella.
OX   NCBI_TaxID=268474 {ECO:0000313|EMBL:KRZ75357.1, ECO:0000313|Proteomes:UP000054843};
RN   [1] {ECO:0000313|EMBL:KRZ75357.1, ECO:0000313|Proteomes:UP000054843}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISS1980 {ECO:0000313|EMBL:KRZ75357.1};
RA   Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT   "Evolution of Trichinella species and genotypes.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
CC       1.A.6) family. {ECO:0000256|ARBA:ARBA00007193,
CC       ECO:0000256|RuleBase:RU000679}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KRZ75357.1}.
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DR   EMBL; JYDO01000039; KRZ75357.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0V1MU89; -.
DR   Proteomes; UP000054843; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005272; F:sodium channel activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.470.10; Acid-sensing ion channels like domains; 1.
DR   Gene3D; 1.10.287.770; YojJ-like; 1.
DR   InterPro; IPR004726; Deg-1.
DR   InterPro; IPR001873; ENaC.
DR   InterPro; IPR020903; ENaC_CS.
DR   NCBIfam; TIGR00867; deg-1; 1.
DR   PANTHER; PTHR11690; AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED; 1.
DR   PANTHER; PTHR11690:SF248; DEGENERIN-LIKE PROTEIN UNC-105; 1.
DR   Pfam; PF00858; ASC; 1.
DR   PRINTS; PR01078; AMINACHANNEL.
DR   PROSITE; PS01206; ASC; 1.
PE   3: Inferred from homology;
KW   Ion channel {ECO:0000256|RuleBase:RU000679};
KW   Ion transport {ECO:0000256|RuleBase:RU000679};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054843};
KW   Sodium {ECO:0000256|ARBA:ARBA00023053};
KW   Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW   ECO:0000256|RuleBase:RU000679};
KW   Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW   ECO:0000256|RuleBase:RU000679};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU000679};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU000679}.
FT   TRANSMEM        45..71
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        600..622
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          267..292
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          653..678
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         698
FT                   /evidence="ECO:0000313|EMBL:KRZ75357.1"
SQ   SEQUENCE   698 AA;  80018 MW;  586BA402CBD19CA1 CRC64;
     MSNRVTFQRD TTTKRRFKNL LLNFSDKTTA HGVPRIGMAT TKREGAFWTF VCVISLTVFL
     FQLSLLIARF LRFETTTQVE LKFETSLFPV VTLCNLNPYR NSLLKQVDQM KLMFDAFDNK
     PLSTPKTSTL LARKRRASSA DEKQYRYTPL YARCSCPNEE SDCVPFTSAP LEDGEEICIC
     YFDHVTKSPW PCYSEKQWRS EWCSRCSQNG NCLQILKKRQ LSLYEDVKQC ICHSNGKTCL
     VADKNKPERI WDPAYRDVRM DRYTTSTTTT TTTTTTTTTT TTTTTTTPIP TTPSEVQEYV
     DALGFEGITD ETAKVSRAQE NTLFIMAELP PETKKKVSHQ KKDFLLQCSF NGRQCDIEND
     FELLMDPVYG NCYMFNSNST INRTTSRAGP IYGLSLVIYV DADDYLPTTK ASGVRLLVHS
     QEEYPFPDTN GYNAPTGLLS SFGIRMKKIE RLPQPYGDCI KEGKTKDYIY QDQIYSLEGC
     YRSCFQMEMI KSCGCGDPRF PVPEGRRHCR VKERKARECL ENVIQKSGGL HGSFAGKCDC
     RQPFNTCMTC RFPLQNGQLL LLRKNALSLE IYFEQLNYEV LKELQAYQWV NLMADFGGQL
     GLWMGVSVIT IIEVLVLIYE VIKMCCTRRK KPTMNKHHRR SIYDDSTVEM TIKIHPPNQN
     NPKDSVTTGH SENDDECSQN SYAMENHLHR HNAEIPNS
//