ID A0A0V1MZ27_9BILA Unreviewed; 878 AA.
AC A0A0V1MZ27;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Sodium/calcium exchanger 1 {ECO:0000313|EMBL:KRZ77046.1};
DE Flags: Fragment;
GN Name=SLC8A1 {ECO:0000313|EMBL:KRZ77046.1};
GN ORFNames=T10_3976 {ECO:0000313|EMBL:KRZ77046.1};
OS Trichinella papuae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=268474 {ECO:0000313|EMBL:KRZ77046.1, ECO:0000313|Proteomes:UP000054843};
RN [1] {ECO:0000313|EMBL:KRZ77046.1, ECO:0000313|Proteomes:UP000054843}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS1980 {ECO:0000313|EMBL:KRZ77046.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Ca(2+)(in) + 3 Na(+)(out) = Ca(2+)(out) + 3 Na(+)(in);
CC Xref=Rhea:RHEA:69955, ChEBI:CHEBI:29101, ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|ARBA:ARBA00033667};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19)
CC family. SLC8 subfamily. {ECO:0000256|ARBA:ARBA00007489}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ77046.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JYDO01000023; KRZ77046.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V1MZ27; -.
DR Proteomes; UP000054843; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005432; F:calcium:sodium antiporter activity; IEA:InterPro.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007154; P:cell communication; IEA:InterPro.
DR Gene3D; 2.60.40.2030; -; 2.
DR Gene3D; 1.20.1420.30; NCX, central ion-binding region; 2.
DR InterPro; IPR038081; CalX-like_sf.
DR InterPro; IPR003644; Calx_beta.
DR InterPro; IPR004836; Na_Ca_Ex.
DR InterPro; IPR004837; NaCa_Exmemb.
DR InterPro; IPR044880; NCX_ion-bd_dom_sf.
DR PANTHER; PTHR11878:SF76; NA_CA EXCHANGERS; 1.
DR PANTHER; PTHR11878; SODIUM/CALCIUM EXCHANGER; 1.
DR Pfam; PF03160; Calx-beta; 2.
DR Pfam; PF01699; Na_Ca_ex; 2.
DR PRINTS; PR01259; NACAEXCHNGR.
DR SMART; SM00237; Calx_beta; 2.
DR SUPFAM; SSF141072; CalX-like; 2.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Calcium {ECO:0000256|ARBA:ARBA00022568};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568};
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion transport {ECO:0000256|ARBA:ARBA00022568};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000054843};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022568}.
FT TRANSMEM 74..99
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 172..193
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 205..228
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 234..255
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 704..734
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 740..760
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 781..798
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 810..830
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 850..872
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 386..485
FT /note="Calx-beta"
FT /evidence="ECO:0000259|SMART:SM00237"
FT DOMAIN 502..609
FT /note="Calx-beta"
FT /evidence="ECO:0000259|SMART:SM00237"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KRZ77046.1"
SQ SEQUENCE 878 AA; 96675 MW; 41022F0454DFE7EA CRC64;
LLLCHGVAEP TGQWSAWDID QQLRRHSSAK PFCSMLQYNN GTALVLVENA YACADRGLLL
PLIDESRWPT ATRAFLYLIG LLYSFVGVAI LADSFMCAVE RITSTKRTLK LQTAVDEETG
SVLEQYQEVL IWNPTVANLT LMALGSSAPE ILLSIIEIIG NGFKAGDLGP GTIVGSAAFN
LFIITAVCIL SVGCGSKKRI EDFQVFCVTT GWSVFAYIWL IIVLVLVSPN RIEVWEGLLT
LLFFGALLLH AYLVSKQLCS GGRGRSRATT DRDRTPKALR ELNRRSWAGP AINGKEKLLD
VVEQNRVDRL SRELRRKYPH LTDDSLAEVV AKQIEKETPH DRLWYRIMAV RRLASSMRSR
LQAKPVSEQV CQKLETLSRT GMLRRTQTET GVRSVTNVEF AANAYAVDPT GERRVRLKVV
RRGSARKQLV FNYRTISGSA VQDVHFLKKS ETVVFAPQER EKTIRIEVCN PAQWRPGLTF
WVKLELIPGD TDDRITLGLA SAAKIIYPKA AVGESVEFAL SDLRVGENEG FARIPISRRA
PLSTDPRSIF SSASVEWKAE NGTAKQGEDF VGEKGELIME PGVVEAYIDI PIVNDYEPEK
DETFTVKLLP GKASLGACQS IVVTIVNDDN ICRYYAKFEE KVRHSLLTCK LESSTWKEQL
LKAVSVNGGE TSDASMVDCL AHIVAFPWKV IAAFVPPTTI FGGWLAFIVA LALIGLLTAI
IGDLAAIFGC LVGLKDSVTA ITFVALGTSL PDTFASRLAA LQDKTADNAI GNINGSNSVN
VFLGLGLPWF IASCYWTARG EAFVVHSGDI GFSVTIYTVL SLICIVMMML RRFLPVLGEA
ELGGPTIPKW LCSVALILFW LLYILLSALQ AYGHISSF
//
