ID A0A0V1N3W4_9BILA Unreviewed; 1058 AA.
AC A0A0V1N3W4;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=Latrophilin Cirl {ECO:0000256|ARBA:ARBA00015543};
GN Name=lat-1 {ECO:0000313|EMBL:KRZ78743.1};
GN ORFNames=T10_4678 {ECO:0000313|EMBL:KRZ78743.1};
OS Trichinella papuae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=268474 {ECO:0000313|EMBL:KRZ78743.1, ECO:0000313|Proteomes:UP000054843};
RN [1] {ECO:0000313|EMBL:KRZ78743.1, ECO:0000313|Proteomes:UP000054843}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS1980 {ECO:0000313|EMBL:KRZ78743.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBUNIT: Forms a heterodimer, consisting of a large extracellular
CC region non-covalently linked to a seven-transmembrane moiety.
CC {ECO:0000256|ARBA:ARBA00011834}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family. LN-TM7
CC subfamily. {ECO:0000256|ARBA:ARBA00010933}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ78743.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JYDO01000010; KRZ78743.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V1N3W4; -.
DR STRING; 268474.A0A0V1N3W4; -.
DR Proteomes; UP000054843; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR CDD; cd15440; 7tmB2_latrophilin-like_invertebrate; 1.
DR Gene3D; 2.60.120.740; -; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 4.10.1240.10; GPCR, family 2, extracellular hormone receptor domain; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR048072; 7tmB2_latrophilin-like.
DR InterPro; IPR032471; GAIN_dom_N.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR InterPro; IPR001879; GPCR_2_extracellular_dom.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR000922; Lectin_gal-bd_dom.
DR InterPro; IPR043159; Lectin_gal-bd_sf.
DR PANTHER; PTHR12011; ADHESION G-PROTEIN COUPLED RECEPTOR; 1.
DR PANTHER; PTHR12011:SF347; LATROPHILIN CIRL; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF16489; GAIN; 1.
DR Pfam; PF02140; Gal_Lectin; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF02793; HRM; 1.
DR PRINTS; PR00249; GPCRSECRETIN.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00008; HormR; 1.
DR SUPFAM; SSF111418; Hormone receptor domain; 1.
DR PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS50228; SUEL_LECTIN; 1.
PE 3: Inferred from homology;
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Lectin {ECO:0000256|ARBA:ARBA00022734};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000054843};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..1058
FT /note="Latrophilin Cirl"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5006883100"
FT TRANSMEM 534..559
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 571..589
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 595..617
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 638..658
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 678..704
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 729..752
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 758..781
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 26..115
FT /note="SUEL-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50228"
FT DOMAIN 175..231
FT /note="G-protein coupled receptors family 2 profile 1"
FT /evidence="ECO:0000259|PROSITE:PS50227"
FT DOMAIN 534..782
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 971..991
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1058 AA; 119544 MW; D508C158226F1113 CRC64;
MRICIFFFAF GLVAMAQTAK QLTQYACEGD MLTLSCPPMQ LIRIVRANYG RFSLNVCNED
GHDWPNTQCM DPSSTGVLAD RCNEKRNCSV SANARIFKDR CPDTSKYLEV IYECLPEADS
EMTHEAELLK TTEIINEQKF KPLLSTAIPK PWPDFVDEDT IVIEAEQSIN LEHRFCTTFR
DRGIEWPKTP AGNFVRIPCP SNMEEYAEMR CDLNGFWVFS KADLSKCTSS WTKPIKLALT
DLTRANESFM EVQRALRRGT RHHDLFGVGT FLTGMVEGAS KLYRKNPLHQ QRRIYTDLVK
TVVDTVSNVL QNGQTAAWND LNEQKCKQVS NKLIEGVEKS AMLLATTMSP RSGIEAISSP
HIMIEISIVS VQNYIQFPSR SLYDPKTDSV QLPRSALQGR ADDDWSKVIF VSYDGIGKRM
RPDARFDRPE IQRVVVSKVV STVVNMDTAI RGLREPVIIT FWVPNQENMS NPSCVFWDKS
VIMNGVIGEW STQGCSLLHH NKSHIVCRCN HLTSFAVLMD VHGVDVSAED LTTLSIITCI
GCAISVICLF ATLISFFMFR SLQCERITIH KNLCLCLLIA EVVFLFGIRQ TSNPLACGII
AVMLHFFFLA AFAWMLLEGF QLYSLLVDVF QPERNREKFY YAFAYGLPLV IVAVSLGVDY
SKYGTQDYCW LSTEEYFILS FVGPAAFVLC MNFVFLLVSI LIVVRHSPYS KSESPRHGQT
MAVNTRFKMW LKGSVMLVIL LGLTWSLGFL FVNHSTLFFA YAFTVLNSLQ GAFIFVFQVL
LQKKVRKEWN NWVRKHFLSK RWSATRRDYG YNPVGCVNTS KMIKAYVDIY PRSTGFLTTA
PNMYSQNTSR SPVLYSSRHL TSDSHLEYAS AIAPDLIVPA DSSSGKCHYA VYTPKYAMGT
TYLPGHSRLT TQGTHKPPPR FPPPIPPVEY CSNSICTDNT YLCTFGIPRR REELDSGYGE
SDATVRKQII SKSQTGEGDR PVSPVDSPCI ASSSKSASEW SYEIPLSSPQ QISFSGCQCS
GMATPYQTTA NCNIFCNFYF YPFQIYQLMM AECLNSKD
//
