ID A0A0V1N9G2_9BILA Unreviewed; 2969 AA.
AC A0A0V1N9G2;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Neurofibromin {ECO:0000313|EMBL:KRZ80648.1};
DE Flags: Fragment;
GN Name=N {ECO:0000313|EMBL:KRZ80648.1};
GN ORFNames=T10_4043 {ECO:0000313|EMBL:KRZ80648.1};
OS Trichinella papuae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=268474 {ECO:0000313|EMBL:KRZ80648.1, ECO:0000313|Proteomes:UP000054843};
RN [1] {ECO:0000313|EMBL:KRZ80648.1, ECO:0000313|Proteomes:UP000054843}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS1980 {ECO:0000313|EMBL:KRZ80648.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ80648.1}.
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DR EMBL; JYDO01000002; KRZ80648.1; -; Genomic_DNA.
DR Proteomes; UP000054843; Unassembled WGS sequence.
DR GO; GO:0070966; P:nuclear-transcribed mRNA catabolic process, no-go decay; IEA:InterPro.
DR GO; GO:0070481; P:nuclear-transcribed mRNA catabolic process, non-stop decay; IEA:InterPro.
DR GO; GO:0071025; P:RNA surveillance; IEA:InterPro.
DR CDD; cd13313; PH_NF1; 1.
DR CDD; cd05130; RasGAP_Neurofibromin; 1.
DR Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR004405; Transl-rel_pelota.
DR PANTHER; PTHR10853; PELOTA; 1.
DR PANTHER; PTHR10853:SF0; PROTEIN PELOTA HOMOLOG; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF00616; RasGAP; 2.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000054843}.
FT DOMAIN 1342..1553
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT REGION 530..550
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1192..1224
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2673..2771
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1199..1220
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2673..2710
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2753..2771
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KRZ80648.1"
SQ SEQUENCE 2969 AA; 333350 MW; B3B0CB6011670A39 CRC64;
LSNGIYAYFC RKVKLFLNVM KAFSFQKPLE WVSSLLARFE DQLPVKTGPL KNQSRLLLEQ
SRACLVNVSK LKFSMVVGGL IRVLQTVNSM KTSAEQDLFD SQCFILDTLE RCLAGPQDVS
SRIDEANNVK IIIHEMCQFI QLSSDSNQAI QLKEKASKVI YNLSLSSFNV IFNRIVAKLK
AVSCEPSAVS VPSDLMTSSS DNVDIELMQY IHFDLKSLIK LLREISYHKP FKKENNQILF
RSLENVIWNW MDTYPDQFHN LQVEQNNELN DCCDRLFDQL DTYGAESSKK KAIVWPLQMM
LLILCPKVLE EIHHISCGAP CPIRLLKKKV FFDSIKKTMS QGHSHTCKHH LLSSACIAGV
KLCKAAIYVN VVDSANVFFA LLQLIITDLK SYLFNPIKPL FKNPSSAQEL DVMIDCFVAL
FRLSYNNEVF RICLNAHTVV PHQLVLVMAL YRIAVQARLP WWPKIDLVYS RSGELLQMFN
ETLSRVCQGA SVVGCMLSTA PTQQSSHGQA STTHMPLRVT HSLHRMTGKL KEKSLTGSQA
SSTGGAGGGA GGGGCVGGCT VASAASVSSL TGNASNSSVE DGCQQLLFWL IRLMCIEPTL
FLHHSPESST LAPSSSTAEL ISGLVNLVGN SNQMPELAQE AMEAILCLHH PENIRMWHPD
STFTTVQSLW YISSQLLFYI CQKLLQFQLA NFSETLRWLR QLLVYRNLYL LSNREIANYG
SSEQLCKQAA QKLETVCFVY LWSLDNDTAI TALSVFRILC EEAEIRCSGD ELPVEYADHA
ELASATNLQT VGRVVLQKSI NSYLKKLLIP SAGCCEAWEA TYRYWEALTK FLKAYPKSKQ
EDSYQVVENL IKQLISQKLG RSSEQEFEMT VKLWANMTGF LCSVGGVVIK SCKNTTLYYD
SSGNLPPSAE TSDKSTTAAA SDLSTSTPDL FCSVNSFLSQ LLTLLLVQSD KLEVAVVRHI
KELCSYELHQ LLIGHFFEQI RTITDRFIDN DDVIIICLRN TEFIEHVVYI MKNILLGCCK
QNVRNVEISC IEPIMLNLCR YVHHLEVNCQ SVTIKGKICQ LIEVIMRNYE NIIFRSEIRF
RNRLVDMIAD WVICNNSPSA SSCIAAVVGV GAFPSEASLP LRDFNTLCMV ALGALMRDLP
LQPNCPNLTT GQNNLQNTAV LNKSQLFQKH FSLFMNVLND CAMNENTGAG DFEIDTVSRG
DDTSSQPSVE DTSASSVPHV TRGTGRVGVG AGATGVGRRF RETKTEQLRR ATILAMSNLL
AANIDIGLVH AVGMAYHRDR RARVAFVEVL TKILQEGTEF ETLNETVMAD RFDELVKLTT
MITVDGELPI VNALASVVQT EHMDELARVL TTLFSSKNLL HELLWKLFIK EVELAEAPTT
LFRGNTVASK VMGYCFKLYG AKYLHSLLHD FVNATVEHST SNYEIDPSRL EADDNLAENT
TNLMELVESI LSLIVHSADR FPVQLKGMLN VLFYVVNARF PNTGLLAVGM IVFLRFFNPA
IGRTIENFKY HSAILFNFIP VSPFEYGLTE NYPNANVKRG LMLVSKILQQ IANQTISLKE
SCLQPFNAFI QSKFEPTRRF FMNIAVEFRF DADASSQYYM SYMNDTPTCA LHRLLWQYQD
KIGEFFTTMR SHDRVARRLA TLLAQLGPAN GRAGSKQWTN VDLDSTRFEE LMSRQSAADK
DEYNSIKENN IFYQCGISRA SNPVFYFIAN RFKVGEVNGN MLIYHVLMSL KSKRNEHFEL
VVDLTHASTE NRFRTELLHK WFLVLSEAMQ QNIIAAYICN CNSWTRDYIR FHERLFRPLK
ANHKLYFLDH VHQLNDYISP EWQRLPVSTL QIDEDVLTFN NALKICHKNM KCSIKVGPTS
LQITTLDRQK VLGHNVILND VYYASEIQEV CLVDDSSMTL TILNECSPLT LMHADCEQIA
SAIVNLRTRY ELSQPDQAVL HAKIRAKDVP GTLLNMALLN LGSTYASLRT AAYNLLCALA
ATFNFRIEGQ LLETEGLLIP ANNTIFIKNI SEKLAMNETH LTLEFLHECI QGFRQSPIDL
KHLCLEYITP WLGNLPRFCR VSGNDNSKRR AVSKVLEKLI TLTIEEIEMY PSIQAKIWGS
IGRLSELLDI ILDRFLKRSI TGGFGSMPAE VMADTSVALA AANTKLVSDI LIGRLMQVLE
KSCLNPQATL EEHILWDDIA ILARYLLFQS FNNCLDVISH LPVLFHFVTV LVNTGPLALR
ASIHGLVVNV IHSLCTCPSS FSETTKANLR LALTEFFLPK FYRLFGVSNL TVKSVAATAF
RISPRMSLPI HCSGDYMASG SIAPRQDRLT LPNLETIADS LVDLLETCNQ DIKNRDLCNE
WEKISYYFTM RFNPALQSRA LVVYSCLSKK TDESVIKQLL NLLLQFVKRR DDCNLLSAVL
MALRRLTPLL PSIHCTLLAR LFWISVIILQ LEDASLYEHG LALLEQILRS LDSLNVFEYE
PFEKVMMEAR PLLEWEFKAM DQQMGISFKH NFHFAVVAYL LKGYRHPSQS VVSRTVRLFS
LILGIVAKYT KRDRYEVTVE NVAYLVALLP VSEEVRLRCP LRHSTLRALS LCGPSENASN
NDPTVGSFPS PAQADKLQPC SRRSALCIQR LQHSCDSLQT LAAARSASTV GSGKLMRTVT
GAGDTFSGQM WSPSSMTVVG FTGQRSRSLP LSGLSTCSLS LPNENGQEQQ EQQQQQQQEQ
QEQQQQEYPD KSEQNCKDSN EDDRPSAAAT TTAAEKSTTK SEPTDESEES KAQQQRLNSN
GKNGGGQTGQ SSRTAFYENL LLDEDVLCEP SLQVLVLTVL GTLVRNYADE NETRTLFEYL
AEASLVFPKV FPVIHCLLDQ RITQVLQMSH DAAVLRAVLH IIQNMIPSQE TTDTYQQQHL
TLLQSYGFGG FWRFAGPFSL KSTAQLQIAP ESLTCLERLI GSLGEVHLQT PPPLSPFGTS
EVGYFRQESF SGTSRANSVT LERSATSDG
//
