ID A0A0V1N9J1_9BILA Unreviewed; 2961 AA.
AC A0A0V1N9J1;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Neurofibromin {ECO:0000313|EMBL:KRZ80650.1};
DE Flags: Fragment;
GN Name=N {ECO:0000313|EMBL:KRZ80650.1};
GN ORFNames=T10_4043 {ECO:0000313|EMBL:KRZ80650.1};
OS Trichinella papuae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=268474 {ECO:0000313|EMBL:KRZ80650.1, ECO:0000313|Proteomes:UP000054843};
RN [1] {ECO:0000313|EMBL:KRZ80650.1, ECO:0000313|Proteomes:UP000054843}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS1980 {ECO:0000313|EMBL:KRZ80650.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ80650.1}.
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DR EMBL; JYDO01000002; KRZ80650.1; -; Genomic_DNA.
DR Proteomes; UP000054843; Unassembled WGS sequence.
DR GO; GO:0070966; P:nuclear-transcribed mRNA catabolic process, no-go decay; IEA:InterPro.
DR GO; GO:0070481; P:nuclear-transcribed mRNA catabolic process, non-stop decay; IEA:InterPro.
DR GO; GO:0071025; P:RNA surveillance; IEA:InterPro.
DR CDD; cd13313; PH_NF1; 1.
DR CDD; cd05130; RasGAP_Neurofibromin; 1.
DR Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR004405; Transl-rel_pelota.
DR PANTHER; PTHR10853; PELOTA; 1.
DR PANTHER; PTHR10853:SF0; PROTEIN PELOTA HOMOLOG; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF00616; RasGAP; 2.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000054843}.
FT DOMAIN 1342..1553
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT REGION 530..550
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1192..1224
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2665..2763
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1199..1220
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2665..2702
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2745..2763
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KRZ80650.1"
SQ SEQUENCE 2961 AA; 332524 MW; CB95045AAF9F8E09 CRC64;
LSNGIYAYFC RKVKLFLNVM KAFSFQKPLE WVSSLLARFE DQLPVKTGPL KNQSRLLLEQ
SRACLVNVSK LKFSMVVGGL IRVLQTVNSM KTSAEQDLFD SQCFILDTLE RCLAGPQDVS
SRIDEANNVK IIIHEMCQFI QLSSDSNQAI QLKEKASKVI YNLSLSSFNV IFNRIVAKLK
AVSCEPSAVS VPSDLMTSSS DNVDIELMQY IHFDLKSLIK LLREISYHKP FKKENNQILF
RSLENVIWNW MDTYPDQFHN LQVEQNNELN DCCDRLFDQL DTYGAESSKK KAIVWPLQMM
LLILCPKVLE EIHHISCGAP CPIRLLKKKV FFDSIKKTMS QGHSHTCKHH LLSSACIAGV
KLCKAAIYVN VVDSANVFFA LLQLIITDLK SYLFNPIKPL FKNPSSAQEL DVMIDCFVAL
FRLSYNNEVF RICLNAHTVV PHQLVLVMAL YRIAVQARLP WWPKIDLVYS RSGELLQMFN
ETLSRVCQGA SVVGCMLSTA PTQQSSHGQA STTHMPLRVT HSLHRMTGKL KEKSLTGSQA
SSTGGAGGGA GGGGCVGGCT VASAASVSSL TGNASNSSVE DGCQQLLFWL IRLMCIEPTL
FLHHSPESST LAPSSSTAEL ISGLVNLVGN SNQMPELAQE AMEAILCLHH PENIRMWHPD
STFTTVQSLW YISSQLLFYI CQKLLQFQLA NFSETLRWLR QLLVYRNLYL LSNREIANYG
SSEQLCKQAA QKLETVCFVY LWSLDNDTAI TALSVFRILC EEAEIRCSGD ELPVEYADHA
ELASATNLQT VGRVVLQKSI NSYLKKLLIP SAGCCEAWEA TYRYWEALTK FLKAYPKSKQ
EDSYQVVENL IKQLISQKLG RSSEQEFEMT VKLWANMTGF LCSVGGVVIK SCKNTTLYYD
SSGNLPPSAE TSDKSTTAAA SDLSTSTPDL FCSVNSFLSQ LLTLLLVQSD KLEVAVVRHI
KELCSYELHQ LLIGHFFEQI RTITDRFIDN DDVIIICLRN TEFIEHVVYI MKNILLGCCK
QNVRNVEISC IEPIMLNLCR YVHHLEVNCQ SVTIKGKICQ LIEVIMRNYE NIIFRSEIRF
RNRLVDMIAD WVICNNSPSA SSCIAAVVGV GAFPSEASLP LRDFNTLCMV ALGALMRDLP
LQPNCPNLTT GQNNLQNTAV LNKSQLFQKH FSLFMNVLND CAMNENTGAG DFEIDTVSRG
DDTSSQPSVE DTSASSVPHV TRGTGRVGVG AGATGVGRRF RETKTEQLRR ATILAMSNLL
AANIDIGLVH AVGMAYHRDR RARVAFVEVL TKILQEGTEF ETLNETVMAD RFDELVKLTT
MITVDGELPI VNALASVVQT EHMDELARVL TTLFSSKNLL HELLWKLFIK EVELAEAPTT
LFRGNTVASK VMGYCFKLYG AKYLHSLLHD FVNATVEHST SNYEIDPSRL EADDNLAENT
TNLMELVESI LSLIVHSADR FPVQLKGMLN VLFYVVNARF PNTGLLAVGM IVFLRFFNPA
IGRTIENFKY HSAILFNFIP VSPFEYGLTE NYPNANVKRG LMLVSKILQQ IANQTISLKE
SCLQPFNAFI QSKFEPTRRF FMNIAVEFRF DADASSQYYM SYMNDTPTCA LHRLLWQYQD
KIGEFFTTMR SHDRVARRLA TLLAQLGPAN GRAGSKQWTN VDLDSTRFEE LMSRQSAADK
DEYNSIKENN IFYQCGISRA SNPVFYFIAN RFKVGEVNGN MLIYHVLMSL KSKRNEHFEL
VVDLTHASTE NRFRTELLHK WFLVLSEAMQ QNIIAAYICN CNSWTRDYIR FHERLFRPLK
ANHKLYFLDH VHQLNDYISP EWQRLPVSTL QIDEDVLTFN NALKICHKNM KCSIKVGPTS
LQITTLDRQK VLGHNVILND VYYASEIQEV CLVDDSSMTL TILNECSPLT LMHADCEQIA
SAIVNLRTRY ELSQPDQAVL HAKIRAKDAL LNLGSTYASL RTAAYNLLCA LAATFNFRIE
GQLLETEGLL IPANNTIFIK NISEKLAMNE THLTLEFLHE CIQGFRQSPI DLKHLCLEYI
TPWLGNLPRF CRVSGNDNSK RRAVSKVLEK LITLTIEEIE MYPSIQAKIW GSIGRLSELL
DIILDRFLKR SITGGFGSMP AEVMADTSVA LAAANTKLVS DILIGRLMQV LEKSCLNPQA
TLEEHILWDD IAILARYLLF QSFNNCLDVI SHLPVLFHFV TVLVNTGPLA LRASIHGLVV
NVIHSLCTCP SSFSETTKAN LRLALTEFFL PKFYRLFGVS NLTVKSVAAT AFRISPRMSL
PIHCSGDYMA SGSIAPRQDR LTLPNLETIA DSLVDLLETC NQDIKNRDLC NEWEKISYYF
TMRFNPALQS RALVVYSCLS KKTDESVIKQ LLNLLLQFVK RRDDCNLLSA VLMALRRLTP
LLPSIHCTLL ARLFWISVII LQLEDASLYE HGLALLEQIL RSLDSLNVFE YEPFEKVMME
ARPLLEWEFK AMDQQMGISF KHNFHFAVVA YLLKGYRHPS QSVVSRTVRL FSLILGIVAK
YTKRDRYEVT VENVAYLVAL LPVSEEVRLR CPLRHSTLRA LSLCGPSENA SNNDPTVGSF
PSPAQADKLQ PCSRRSALCI QRLQHSCDSL QTLAAARSAS TVGSGKLMRT VTGAGDTFSG
QMWSPSSMTV VGFTGQRSRS LPLSGLSTCS LSLPNENGQE QQEQQQQQQQ EQQEQQQQEY
PDKSEQNCKD SNEDDRPSAA ATTTAAEKST TKSEPTDESE ESKAQQQRLN SNGKNGGGQT
GQSSRTAFYE NLLLDEDVLC EPSLQVLVLT VLGTLVRNYA DENETRTLFE YLAEASLVFP
KVFPVIHCLL DQRITQVLQM SHDAAVLRAV LHIIQNMIPS QETTDTYQQQ HLTLLQSYGF
GGFWRFAGPF SLKSTAQLQI APESLTCLER LIGSLGEVHL QTPPPLSPFG TSEVGYFRQE
SFSGTSRANS VTLERSATSD G
//
