ID A0A0V1NIZ5_9BILA Unreviewed; 1437 AA.
AC A0A0V1NIZ5;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Metabotropic glutamate receptor 5 {ECO:0000313|EMBL:KRZ83960.1};
GN Name=GRM5 {ECO:0000313|EMBL:KRZ83960.1};
GN ORFNames=T08_7055 {ECO:0000313|EMBL:KRZ83960.1};
OS Trichinella sp. T8.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=92180 {ECO:0000313|EMBL:KRZ83960.1, ECO:0000313|Proteomes:UP000054924};
RN [1] {ECO:0000313|EMBL:KRZ83960.1, ECO:0000313|Proteomes:UP000054924}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS272 {ECO:0000313|EMBL:KRZ83960.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family.
CC {ECO:0000256|ARBA:ARBA00007242}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ83960.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JYDM01000190; KRZ83960.1; -; Genomic_DNA.
DR Proteomes; UP000054924; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR CDD; cd15285; 7tmC_mGluR_group1; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR000162; GPCR_3_mtglu_rcpt.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24060:SF134; G_PROTEIN_RECEP_F3_4 DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24060; METABOTROPIC GLUTAMATE RECEPTOR; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00248; GPCRMGR.
DR PRINTS; PR00593; MTABOTROPICR.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00980; G_PROTEIN_RECEP_F3_2; 1.
DR PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:KRZ83960.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000054924};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..1437
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5006883429"
FT TRANSMEM 613..634
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 646..665
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 677..694
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 715..742
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 768..787
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 799..821
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 827..847
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 917..941
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 953..974
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 608..869
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
FT REGION 879..901
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 988..1085
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1148..1170
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1189..1222
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1404..1429
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1004..1052
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1053..1074
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1150..1170
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1194..1208
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1437 AA; 160303 MW; 7C543318F1D97984 CRC64;
MLMVVVSIWL AVSLTAVLAP KSASHTRVAR IPGDVEIGAL FPIHRKIAGT ERCGEIWEQY
GIQRTEIALK TVDAINDDNA LLANLKLGIS VRDDCWTERI AMEQTIIMVR DAVGGPNAHS
KQQRCCCCPE DKHCQANDGD EPTSNLVAVI GPGSSDVSIA VQNLLQVFHI PQVGYSATTK
ALSDKTEFKY YMRMVPSDSW QAKAIVDIVK YFHWSYVAVV YTDGNYGEKG FEELQKNFDK
EDNLCIGVAE KIKSLAPAAD YDALIRLLMT HRPQITVAIC FCEGDTIKRI FQATKRVRES
LQPDGNDTYQ GLQWIGSESW SDRKDVVAGV EDVAAGGFSF RIYSPRMTQF DSYYFNLTPK
NNFRNPWFVD FWEEKFHCSY TESTRNLYPK ICTGNENVSY GYKPDPKLSQ VTNAIYTVAY
ALDAMYNDLC KGSKEKGLCD AMTPVDGTVL FQYMLKTMFR DPSGQEIYFD ANGDPPARYD
ILNYQGKVAS YVTAGEWDHS FHSDKFNHQS GIYYKSKLRI DRDKILWHNH MSGLTYTPTA
RCSYDCKVGE IKKIQTLKCC WICVPCYENE YLLNEYACKR CPLGYWPLEN RTACYKLEVE
YMRWSDAEAV VCVVFACVGI IATLFTIVIF ILHNSTPVVK ATTRELSYII LVGLLLCYMT
TFFIISPPNM VSCIIRRIVP GTAFSMIYGA LFTKTNRIAR ILAASKKITT KRRRFLSISA
QVTITGLLVL VELITIVVFL IFEPPKADFD YSLPKRVLLV CRTSGLTFFA PFGFDLFLVG
MCTLYAVKTR NLPENFNEAK FIGFTMYTTC VIWLAFIAIY FGSAKKDTTM CICFSLSATV
ALILLYFPKM YVILLRPEKN ARSYFKTTTT IRCHFGSNAK SSSSDGGGGG GGGSSGSRIS
SVQGSQRKKR FFKLAPCTTY TTTLLSVYST AASAAYLPAN FGTDGFLHMC TKFYFLLPMP
TMMKSLFFDA FFVFNAEPTF RRYVARNDSH SSYSAQSTPD PAARGRRHSG RFAAGDELTS
RDEQQADESA CKPDECSSDS QRLLRAVDEM PSVKEETDDD GGDDDDDDDD DEPTTSSEHP
VSSRKFLDRT GSLWRRFDPF QQNPQLNRGW RSLRVPAGRN DGEAAPTLLL KIAAERLDTV
RHFIDVDPPA SGSTGTTAAV AERQPRSNVS TISGRASFAR RKGTGHVWFS SSVGETDDDE
EEDGDDDHDK MDTDRRGTTE ETVLHSHKDR LVVCRNSQPE SGEKQTAFSN GGFPVIEFDE
VDMRRTVVLG RSTNKTTAGE DPLPHRRPWG RKVRSNSDTV AWLLQRQSQL SNFTWNLTRS
ESEQLLGPVR GNSLKTLFTR KPFAKQQTKS MPCLRFDATV DTAGTAKQQY SSPGSSSLVT
TALTGFSRAG SMSGSLLLSP IEELSNSSSS GSAKSSNGSS PTSVTVSGYD FSTISLV
//
