ID A0A0V1NNN4_9BILA Unreviewed; 3317 AA.
AC A0A0V1NNN4;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=UDP-glucose:glycoprotein glucosyltransferase 1 {ECO:0000313|EMBL:KRZ85613.1};
GN Name=Uggt1 {ECO:0000313|EMBL:KRZ85613.1};
GN ORFNames=T08_4522 {ECO:0000313|EMBL:KRZ85613.1};
OS Trichinella sp. T8.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=92180 {ECO:0000313|EMBL:KRZ85613.1, ECO:0000313|Proteomes:UP000054924};
RN [1] {ECO:0000313|EMBL:KRZ85613.1, ECO:0000313|Proteomes:UP000054924}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS272 {ECO:0000313|EMBL:KRZ85613.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=N(4)-(alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-
CC (1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-
CC alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-
CC GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan
CC mannose isomer 9A1,2,3B1,2,3) + UDP-alpha-D-glucose = H(+) + N(4)-
CC (alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-
CC Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-
CC (1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-
CC beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + UDP;
CC Xref=Rhea:RHEA:61304, Rhea:RHEA-COMP:14356, Rhea:RHEA-COMP:14357,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:58223, ChEBI:CHEBI:58885,
CC ChEBI:CHEBI:59080, ChEBI:CHEBI:139493;
CC Evidence={ECO:0000256|ARBA:ARBA00034426};
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum lumen
CC {ECO:0000256|ARBA:ARBA00004319}.
CC -!- SIMILARITY: Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB
CC subfamily. {ECO:0000256|ARBA:ARBA00009625}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ85613.1}.
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DR EMBL; JYDM01000137; KRZ85613.1; -; Genomic_DNA.
DR UniPathway; UPA00378; -.
DR Proteomes; UP000054924; Unassembled WGS sequence.
DR GO; GO:0005788; C:endoplasmic reticulum lumen; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003980; F:UDP-glucose:glycoprotein glucosyltransferase activity; IEA:InterPro.
DR GO; GO:0006486; P:protein glycosylation; IEA:UniProtKB-UniPathway.
DR CDD; cd06432; GT8_HUGT1_C_like; 1.
DR CDD; cd03114; MMAA-like; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR040497; Glyco_transf_24.
DR InterPro; IPR005129; GTPase_ArgK.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR029347; Raptor_N.
DR InterPro; IPR009448; UDP-g_GGtrans.
DR InterPro; IPR040693; UGGT_TRXL_1.
DR InterPro; IPR040694; UGGT_TRXL_2.
DR InterPro; IPR040692; UGGT_TRXL_3.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR NCBIfam; TIGR00750; lao; 1.
DR PANTHER; PTHR11226; UDP-GLUCOSE GLYCOPROTEIN:GLUCOSYLTRANSFERASE; 1.
DR PANTHER; PTHR11226:SF0; UDP-GLUCOSE:GLYCOPROTEIN GLUCOSYLTRANSFERASE; 1.
DR Pfam; PF18404; Glyco_transf_24; 1.
DR Pfam; PF03308; MeaB; 1.
DR Pfam; PF14538; Raptor_N; 1.
DR Pfam; PF18400; Thioredoxin_12; 1.
DR Pfam; PF18401; Thioredoxin_13; 1.
DR Pfam; PF18402; Thioredoxin_14; 1.
DR Pfam; PF06427; UDP-g_GGTase; 1.
DR PRINTS; PR01547; YEAST176DUF.
DR SMART; SM01302; Raptor_N; 1.
DR SMART; SM00320; WD40; 4.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000054924};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transferase {ECO:0000313|EMBL:KRZ85613.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..37
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1693..1846
FT /note="Raptor N-terminal CASPase-like"
FT /evidence="ECO:0000259|SMART:SM01302"
FT REGION 1913..1992
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2467..2488
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2567..2607
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2777..2826
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2849..2891
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1938..1961
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1964..1987
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2780..2825
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3317 AA; 373645 MW; A1CAA0135F1F0A85 CRC64;
MTVFCANFTV ESLLEATVYS MWVFPLIVVC FVSPVLVSPR KAHKNVIVSV RSKWPSTSLI
MEASEFMSKE SNEKFWQFIE AVIDKHQNSL GNKTDREVYN GILQIGDQIL KSKARLEFLK
LALTVRVHSA TVEMHRQIAA TSLDVQNGKS VYAVVHGKQI SDLQQLDTIL KHAEALARPV
TYEFDHIYPG SKQGSVCVLL YADIENPHFK PWHLQLKKLV QRDGISYILR HYPKMNDDMV
ALSGYAVELA IKSTEYKAVD DSDKQTGSES GVSSSEEEVT DLNGFNLHLL EADELTPLKV
WQLQHLSFQA GQRVILAPKE EALRVLRDIS QNFPIMARKD FTLLYAMKGN DPNAEYAVDY
TQWSPQIFVL RLGDRASQNL LSTAYQMYEH VLPIRIGFIF VVNNDKSVSG YDDAGVAMLN
AFNFIKEDRS VSKAVMFLIK IYNTSMRETI SVEDVHKLFK SSYRDENLKS VFNSEEYNQG
RSISPEHIEE AILSKVMRFT VDIQKDVYEG NLKENMDVQQ HLLKKPTVLP KLNYNILQME
NIFLDMTDTS MDMRIALIHN PKSEAQATKG TASLVQACIQ FLPLYQSKAG ISWPEFKKAY
NSMSDIWMQL HVHYAKFVLN LDPGVGAIVA NGKIEASDPT AAQFDIVAIV DPLSPAAQKM
SHLLVILSSV LNVHMKVCMN CKSKLSEIPL KNFFRMVLPR ELEFADDGSL KAQPSARFSA
LPQKQLFTLN IIAPQSWMVE SVEAVYDLDN IKMEEVKGDV VAKFQLEYIL LEGRCFDERS
GSPPRGLQFT LGTFHEPFMF DTIVMANLVA KKNDQLENEL LAESEDAESE SLWQSISKTF
QSGEKYDVIN IFSLASGHLY ERFLRIMMLS VLKHTKTAVK FWLLKNYLSP GFKEFLPYMA
GHYNFSYELV QYKWPRWLHQ QTEKQRIMWG YKILFLDVLF PLDVKKIIFV DADQVVRTDM
LNLMELDLEG APYAYTPFCD SRKEMDGYRF WKQGYWENHL AGRKYHISAL YVVDLKKFRQ
VAAGDRLRGQ YHFLSRDPNS LSNLDQDLPN NMIHQVKIKS LPQEWLWCET WCDDKSKKFA
KTIDLCNNPM TKEPKLQSAM RIIEEWKDYD SEIKDLLDQR TKDKWNITEQ KIVDIGFQFT
VYFLVFLEES WNRAMNKENQ VQDNQSDDLP QATESINNAT EMKARQRGMI EKKLRKYVVG
IKNQNSLMKL RIMPANSLGT LRLSNRRLSK KSCGKLLCSD QKMKNDSVDC SRNRDKFKNY
YRKHWDTDIT VEDETVVGLK NRILKGDRSA LASAITLVES NHPTKRAQGE CLLQSMLKIS
KKRFDEHGPK SLIYRIAITG APGAGKSTFI ESFGLYLTRE LKKKIAVLTI DPSSERTGGS
IMGDVARMNE LSKEPNCYIR PSATAGTLGG VRRGTHESVV LCEGAGYDVV LIETVGVGQS
ESAVANIADM VVLLLSPALG DELQGIKRGI MEMADLILVT KADGDLLNQA RLTRAEFSSA
LKYSRSRFHC WRPQVLLVSS RTNKGITEIW NEMEHFRNAL SENGVLLQQR HQQMLRWMWN
HIDHVLSGLF RHHPDVVKML PQLIREIQND NVTPVTAGEK MEHFKKEHWK FRQEKNMLEI
KVSKAAEKVY TDGFDLANAS GSVNLKKNVR MSEENDLHEE EPERVPVSFA DLRREQCEAD
NKIDPEFWRN RERMKTVSVA LVLCLNIGID PPDTVKPKPC ARTECWIDPQ CMPMQKALES
IGTALQRQYQ WWQPRARYKQ ALDPTVDDVR RLCISMRKNA KEERVLFHYN GHGVPRPTKN
CEIWVFNKMF TQYIPLAIYD LQTWMGAPGV YVWDCNGAAQ AIRAFKTCAK KQIQAYRCSL
AARRKESTKT TVEFEPGVDL FQADDARQAE LDRSRRRKTG LDCVSSKPLE VNFRSSSMVP
DGPKIETNNK ATAKDASKHL AGNSSGNNNV RNGQHKNDGN NDDNTNGNDD DDDDDGDYDD
DGEDDFDDDD PRKPKFKHCI QLAACARDQT LPTDPALPAD LFTCCLTTPI RMAVMYYILQ
NKLTDRYPVC IADRIPGSTG DRRSPLGELN WIFTAITDTI AWNLLPSETF QRLFRQDLLI
ASLYRNYLLA DRVMRSYYCT PVSSPRLPPT HEHVMWQAWD MVVESVLEQL DVQALVAEVE
ANEATVMLPP GVPTAAGHGG AGVGAGASTA VAAAAMPGGG TATTGVSDAG SRAVGNDPTL
TAGQQAQHDK VVASVDYKNS PFFSNQLIAF EVWLQYGFYQ GSAPQQLPIV LQVLLSQVLR
VRALELLARF VDLGPKAVEQ ALAVGIFPYI LRLLQSVSRD MRPLLTFIWA KILAVDNSCR
LMLLKDHVHR YFLVHLNDPT VEVRRKLFAV FALARLMADC RQFQEAALCN GFVATCSDLF
SDCNDAPMRQ WLALALGHLW TDYEAAKWQA IRCSLHQTLI GLLEDRLASV RAAAVFALGR
LISTGGAGDK ENKQNDGDQG NHCPNDEQST NLAHSVAMSL VQHVCADSSA TVRREALLGF
FAFVRRFYPQ FVTIAYEIDR ELASSVPSRR HQHHELVSSY TVTTATIVGN NNNNNNNSNN
HNHHNLSNGS SNSIASFSPQ QQQRTRNFGI SSSPVAANVD SSTLVKSTSL LFQPLLTAVS
SSLNSSSNSM INIPLVRPSS RKSVSWLFGL ARSSQENQKA DNSKQEQSSQ ETITVLSRRE
VRRHRSIGPA ALVNVNNVYV SVWRAVLKFL YDPDIEVSRL AHRLFKYVDR SVQNLRLLSS
VGHQDSVDSL PVRRRSTAGY FHSSPDNGTA GQHPSPRPKF SFSGTHDHHQ QQLVNDGNGN
SGGYESPMGA SPIALCTYSA IYTNPRRPVF GDGPASESSV HSSEASPETR RHLAPEREIG
TTAASILSPP VDSEPVMKTD YLSTCAQQFR SPMFYLLSES CAPSPAALNA QPRTTQRILP
SFIADRISLI HQHSSIEWNL LSDKRKKYGK LWTYKNDFPA TCMEFLPLEP LLCIGERDSV
TVWNCNKGSV VAHFDNSSTS YTGQSGSDLS GNLVYLTFVN PYTHGFILTG TDCGEVRVWD
VRLINEPDLT SKVPKGSIDF ALLTAWMCAD DARRFHTKPF TCYFWEQDPG LLFAAGDFRS
IILWDAHTEL KLAELKVGAG GDTYVCTLSA DSNGHHLTAA GCSDGSVRLF DRRLPTSDSR
IMTLRDLGRA VFKVHLEQAS VGGGGGGGGR LVAASRSGQL CIWEPRMYRE PVLFRDVGVR
CRSSFDVHRY YPLIAAWNGA QVDLINFDGK SMGLFRPDVL NMTTTLGRLA ALRFHPVQVS
IGLAEQDGQF SLYGLRP
//
