ID A0A0V1NNU2_9BILA Unreviewed; 1713 AA.
AC A0A0V1NNU2;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=Rho guanine nucleotide exchange factor 12 {ECO:0000313|EMBL:KRZ85695.1};
GN Name=Arhgef12 {ECO:0000313|EMBL:KRZ85695.1};
GN ORFNames=T08_3365 {ECO:0000313|EMBL:KRZ85695.1};
OS Trichinella sp. T8.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=92180 {ECO:0000313|EMBL:KRZ85695.1, ECO:0000313|Proteomes:UP000054924};
RN [1] {ECO:0000313|EMBL:KRZ85695.1, ECO:0000313|Proteomes:UP000054924}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS272 {ECO:0000313|EMBL:KRZ85695.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Membrane {ECO:0000256|ARBA:ARBA00004370}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the eukaryotic
CC ribosomal protein eS31 family. {ECO:0000256|ARBA:ARBA00009891}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the ubiquitin family.
CC {ECO:0000256|ARBA:ARBA00008373}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ85695.1}.
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DR EMBL; JYDM01000135; KRZ85695.1; -; Genomic_DNA.
DR STRING; 92180.A0A0V1NNU2; -.
DR Proteomes; UP000054924; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005840; C:ribosome; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0006412; P:translation; IEA:InterPro.
DR CDD; cd00029; C1; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 6.20.50.150; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041020; PH_16.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR015212; RGS-like_dom.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR044926; RGS_subdomain_2.
DR InterPro; IPR002906; Ribosomal_eS31.
DR InterPro; IPR038582; Ribosomal_eS31_euk-type_sf.
DR InterPro; IPR011332; Ribosomal_zn-bd.
DR InterPro; IPR000626; Ubiquitin-like_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR45872; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 2, ISOFORM D; 1.
DR PANTHER; PTHR45872:SF2; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 2, ISOFORM D; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF17838; PH_16; 1.
DR Pfam; PF09128; RGS-like; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF01599; Ribosomal_S27; 1.
DR Pfam; PF00240; ubiquitin; 1.
DR SMART; SM00109; C1; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM01402; Ribosomal_S27; 1.
DR SMART; SM00213; UBQ; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR SUPFAM; SSF57829; Zn-binding ribosomal proteins; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50053; UBIQUITIN_2; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000054924};
KW Ribonucleoprotein {ECO:0000256|ARBA:ARBA00023274};
KW Ribosomal protein {ECO:0000256|ARBA:ARBA00022980};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 13..75
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 531..581
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 785..971
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 1013..1128
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1551..1623
FT /note="Ubiquitin-like"
FT /evidence="ECO:0000259|PROSITE:PS50053"
FT REGION 85..130
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 216..244
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 656..725
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1133..1156
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 160..187
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 85..99
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 100..126
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 656..678
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 679..705
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 706..725
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1141..1155
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1713 AA; 194388 MW; BF40BBFADB4D8FA7 CRC64;
MHFHGEHFAE ERNVLIKRDE NGYGLTVCGN NPVFVQSVRE GSAAAKAGVH VGECIIKVNG
VTVTSLDHLE VVKLISVAPY TTLTLSGGPS SSSAASSMGN DHYEKRDRCL ERRSTENAIR
PNSKKKQSEW HLKRKKIIQQ ILTEEKRQLQ VMLKGSDAHA DADQRIIEKM TRRIHNLEDQ
LNEVEKLDFE QVELFYKNLI YQENISLSNS GFRSHSDDLS SSLTMKSSKS HSDDVVASSS
TDDERLLTKS GNIDEIRDHQ IPVPVSEVPP ESPLLVHTLS MSNECDSAAV ELNSSSFDEP
FSKLPMLKTH LGHLAVFLHY LLSNSDPSYL LFYLLTDIFA LYIGKESKKW AYEIHSSFLL
PYSPCRVSFT DSSSWETVDA VLNDPNKHAD SAQWRRLFST ARGLAVQAIN EQLADFRSKR
ILGLGNVFGE SMLQRLQAGD SAHERKIFDA LIAPHLIAFF EEAADFDQLP KRIQVIVAAL
ATLYKHNNVK CRNAAMEKLL ERCPTYIAKE KQRFARPLLP KASRRALQIK AHCFNIAPVL
QTTFCYQCQK LIWGIGAMSL FCGKCGVVLH KSCVENLAES CFGSMNLRRP LILKKIVGRK
NVESSMDNIE QSIEEGKVST AKTDASMLLK ENSGEGDGSS EKNLTRNFDK SGVTNAAVSK
QSAHIHNLSR SQSMNIEEES YRGARRRSSD TSRRSHSDAD KTESLTRIST TESSTTVSVQ
DVSRERSPMI SELDSPLTSS VSFSNTLHDI HIELDSDFKV ENEIPLLEDL LDLESFQYLD
KREKNRLEVI YELFHTEQTH VRNLKILYRL FYKQLLNFNV ISFEFASLLF SNLEDVLNLH
VEMNEAMKNM MQNNKLIGDI SIMMLQFDGK ERMRNIDSLH CQKLQSAIEA LKHRVVKDQK
LREFLQVVES LPVCRKLQLK DMLPMEMQRL TKYPLLLENV LKYTEDPSEE ADRLRTCIEC
SRSILESVNS AKRNAENVLR LQRLQQMLDT TQFDKVNHPI VSEFCPLDVR RFSLIHEGPL
IWRLNKSKIV DLHVVLLDEI LLLLSPTSDG HLALRFHNIN ISCGKDEVKW THCPLLKLNS
LIAKDVATDK KAFFLVSTSP SGPQIYELAT QSKAEKQNWF KFIVEQIEAS KEHEQKTSVR
HGQAGQESKS GDSFYEIPNS ARKKSLTVRS QRTMKNPNFD ERVRVTCQPR LISPSEINIC
QPTVFQHSKP ILNPLEKLKQ EDKLVIRLLN EKLQIISSFF GQKNDLPPSS AVDSRTSREA
REFVISAIKQ KSQDLYIFVL ANRLLEAINE QTRLIEMENF ENGSVKYQVP EVECPSVPCY
QLTQIAAGLM TCLTNLLHSL QIMGDDLKRV QRELHQYKLS PERLLPFPEK ICQAVGTDIP
TDVTHEAACR KSLTDAAVQT EPASFLQTNN CDAVKKNAGK STENFHTDDQ PTELSGRSII
KDALPTGSCN TAASEKPILR NGKMGTDGLC LFDTDIAKLE EQPCSEIITK SKNFSNVLHL
QNFTWKEIFQ NNHSDVAFHF LNCCSVMLCV FVREVLVQFW QTVKKLEIEA MQIFVRSGRL
IALNIESNCT IGEIKKQIQE EEESLCSSYL VLGGRPLEDD WTLAQCNIQE FSTLDLSYRL
LGGAKKRKKK MYTTPKKIKH KKKKVKLAVL KYYKIDENGK VSRLRKECTS ESCGAGVFMA
NHYNRQYCGK CYCTMVVQDP VQREQKPGKG KGH
//
