ID A0A0V1NZG8_9BILA Unreviewed; 1591 AA.
AC A0A0V1NZG8;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=Tensin {ECO:0000313|EMBL:KRZ89265.1};
DE Flags: Fragment;
GN Name=TNS {ECO:0000313|EMBL:KRZ89265.1};
GN ORFNames=T08_11941 {ECO:0000313|EMBL:KRZ89265.1};
OS Trichinella sp. T8.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=92180 {ECO:0000313|EMBL:KRZ89265.1, ECO:0000313|Proteomes:UP000054924};
RN [1] {ECO:0000313|EMBL:KRZ89265.1, ECO:0000313|Proteomes:UP000054924}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS272 {ECO:0000313|EMBL:KRZ89265.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the PTEN phosphatase protein family.
CC {ECO:0000256|ARBA:ARBA00007881}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ89265.1}.
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DR EMBL; JYDM01000072; KRZ89265.1; -; Genomic_DNA.
DR Proteomes; UP000054924; Unassembled WGS sequence.
DR GO; GO:0004721; F:phosphoprotein phosphatase activity; IEA:UniProtKB-KW.
DR CDD; cd01213; PTB_tensin; 1.
DR CDD; cd09927; SH2_Tensin_like; 1.
DR Gene3D; 2.60.40.1110; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR013625; PTB.
DR InterPro; IPR006020; PTB/PI_dom.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR035012; Tensin-like_SH2.
DR InterPro; IPR014020; Tensin_C2-dom.
DR InterPro; IPR033929; Tensin_PTB.
DR PANTHER; PTHR45734:SF10; BLISTERY, ISOFORM A; 1.
DR PANTHER; PTHR45734; TENSIN; 1.
DR Pfam; PF08416; PTB; 1.
DR Pfam; PF10409; PTEN_C2; 1.
DR Pfam; PF00017; SH2; 1.
DR SMART; SM00462; PTB; 1.
DR SMART; SM01326; PTEN_C2; 1.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS51182; C2_TENSIN; 1.
DR PROSITE; PS50001; SH2; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022912};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Reference proteome {ECO:0000313|Proteomes:UP000054924};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191}.
FT DOMAIN 246..376
FT /note="C2 tensin-type"
FT /evidence="ECO:0000259|PROSITE:PS51182"
FT DOMAIN 1254..1361
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT REGION 415..493
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 566..588
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 718..760
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 978..1037
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 415..439
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 451..493
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 725..760
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1591
FT /evidence="ECO:0000313|EMBL:KRZ89265.1"
SQ SEQUENCE 1591 AA; 177269 MW; C2849B0B649041A7 CRC64;
MQWNERWKLS RSLFAHNRML IIRKSVARMR GGNGNLSSVQ LVFFCCSCCC PIDFIYKVQH
LHAVLPSPGN IVKSSQRTRN SKVTRNNSCQ PSSMLTFAFA GCDDLYSKSV QLTIKMLASK
HDGKFKIFNV SKERSELANL NVFECGWPEC LAPALEKLCT ICKEMDRWLE LSTENVVVIH
QKGGFRRAAV VVSAFMHYCS ICASESQMLE HLAMQQYCKQ HSLLPSQRRY VQNFANLLSE
RIQVNSEPVV LYTLVVRGLT KRCPVYFKIY GKMVPVFTSN VVSGNAAEVL VARFRPPVSL
RGDILLKCCS AEDEFHQKCT LFQCQFNTCT VNNHSCRKIV FKNDELDYPI SENLSLELFC
AIIEPNCKSE IYPTDDNGNN SSSLSFNTSN IEPVYLEPST DNSFNSFEWF YDHNSSNEDG
SKAEQQSSGG TTLAMRRRRT ATTSPPRDAD PILEPDPEAD LDVDHDRATE AGKDNGRKKR
WLSRGSVESG RRDVEPALER PVVVDVRGKR ASFDVVTADS LGIVDVSPFR VGRAGVDRET
RAPHWAPPQT RRVIDTNYGP FESPFRPPAV VPPGKRAASP APVRVHHARA SPTVDKGDID
VDLVGEDRYD PQSRAFSYVP AQSLEEHFRA PKKPTKLVPA FKYTDNWTVA DEPLVAVEED
PASARVPNFD DLCDPNFYLN FDNGRLSGTA TESHNGAETD HHALSLCTDV SVDCPIGDQG
SNAWGADDND PQQQQQPAAE ASSKPSSTRH PSTFHSNNYH SPLSAATLDS RWSPSPSSRG
DFHFDDLTLG LEPLQTRRYQ HRPGQQLLLF DCSEPTTPRP FNNRCPSPNF YRNRQKLQVE
TRPVYTPTAW EERFLGGLGD QWDDSQRVSM SRRPLYYGNS LPEWPAESDA DSISAGGPVD
SESWLDLQMQ KLKIRREVND PARRRRREQE RLLLEELKQV QHVDGGRGRF GRHGAVAGAV
AGSKGAPLMD ESTASAVSSI SNSSPGRANE ESHTITNNNN TATTTITTPL HPGFTRRKTN
NANTTTVPTS DHDTSPLLDV QSTVGRNRDG LWSSSSSSHR HACYNPHQTN FDHCYYYSNT
LSSTKSASSP KSILKKPKSF PAQPFVSPSY QATEELQSGN YYHDQVDGPD SSSYLKSRID
NTLASTDQPD YASSYMLNSP ARVETPAFPV RRMETPLPYH PLLYAGASTD DSRMMMSRVQ
NKPPPPPPPM SIRSLSPGSH YYAHSVRSSL ASLLETMEVV HHHPVFVKDT SKYWYKPQIS
REETISVLKD KQPGSFIIRD SSSFPGAFGL ALKVATAPPG VMTKGNSDGS ELVRHFLIET
TAKGVKLKGC NNEPVFGSLA ALVYQHSITP LALPCKLLLP DYDPAVSVEQ VTTAQQLLEQ
GAACNVTYLY SNETESLTGP EAIRRTIDSA LVLSSQKKIE PLNVHFKVSS QGITITDNAR
KVFFRRHYPV QTITHCGLDP ENRQWCCNSN SGPARIYGFV ARKSLAKSEN VCHLFAELEP
EQPASAIVNF VNKVIINPNR SHVSSSFMAV VALKSLCQLV TVHHHHHHHQ YPGDHRTSIA
YLRVGEEASS SRLVVFIDEV KKEKTNSSIY T
//
