ID A0A0V1NZK2_9BILA Unreviewed; 817 AA.
AC A0A0V1NZK2;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Tyrosine--tRNA ligase {ECO:0000256|ARBA:ARBA00013160, ECO:0000256|RuleBase:RU361234};
DE EC=6.1.1.1 {ECO:0000256|ARBA:ARBA00013160, ECO:0000256|RuleBase:RU361234};
DE AltName: Full=Tyrosyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00033323, ECO:0000256|RuleBase:RU361234};
GN Name=Uba3 {ECO:0000313|EMBL:KRZ89333.1};
GN ORFNames=T08_12987 {ECO:0000313|EMBL:KRZ89333.1};
OS Trichinella sp. T8.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=92180 {ECO:0000313|EMBL:KRZ89333.1, ECO:0000313|Proteomes:UP000054924};
RN [1] {ECO:0000313|EMBL:KRZ89333.1, ECO:0000313|Proteomes:UP000054924}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS272 {ECO:0000313|EMBL:KRZ89333.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + H(+) + L-
CC tyrosyl-tRNA(Tyr); Xref=Rhea:RHEA:10220, Rhea:RHEA-COMP:9706,
CC Rhea:RHEA-COMP:9707, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:58315, ChEBI:CHEBI:78442,
CC ChEBI:CHEBI:78536, ChEBI:CHEBI:456215; EC=6.1.1.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000069,
CC ECO:0000256|RuleBase:RU361234};
CC -!- PATHWAY: Protein modification. {ECO:0000256|ARBA:ARBA00043952}.
CC -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC {ECO:0000256|RuleBase:RU361234}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ89333.1}.
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DR EMBL; JYDM01000071; KRZ89333.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V1NZK2; -.
DR Proteomes; UP000054924; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0019781; F:NEDD8 activating enzyme activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0004831; F:tyrosine-tRNA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0045116; P:protein neddylation; IEA:InterPro.
DR GO; GO:0006437; P:tyrosyl-tRNA aminoacylation; IEA:InterPro.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.10.290.10; RNA-binding S4 domain; 1.
DR Gene3D; 1.10.240.10; Tyrosyl-Transfer RNA Synthetase; 1.
DR Gene3D; 1.10.10.520; Ubiquitin activating enzymes (Uba3). Chain: B, domain 2; 1.
DR InterPro; IPR001412; aa-tRNA-synth_I_CS.
DR InterPro; IPR002305; aa-tRNA-synth_Ic.
DR InterPro; IPR014929; E2-binding.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR036986; S4_RNA-bd_sf.
DR InterPro; IPR000594; ThiF_NAD_FAD-bd.
DR InterPro; IPR002307; Tyr-tRNA-ligase.
DR InterPro; IPR024088; Tyr-tRNA-ligase_bac-type.
DR InterPro; IPR023318; Ub_act_enz_dom_a_sf.
DR InterPro; IPR035985; Ubiquitin-activating_enz.
DR NCBIfam; TIGR00234; tyrS; 1.
DR PANTHER; PTHR11766:SF0; TYROSINE--TRNA LIGASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11766; TYROSYL-TRNA SYNTHETASE; 1.
DR Pfam; PF08825; E2_bind; 1.
DR Pfam; PF00899; ThiF; 1.
DR Pfam; PF00579; tRNA-synt_1b; 1.
DR PRINTS; PR01040; TRNASYNTHTYR.
DR SMART; SM01181; E2_bind; 1.
DR SUPFAM; SSF69572; Activating enzymes of the ubiquitin-like proteins; 1.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR PROSITE; PS00178; AA_TRNA_LIGASE_I; 1.
PE 3: Inferred from homology;
KW Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146,
KW ECO:0000256|RuleBase:RU361234};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU361234};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|RuleBase:RU361234};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU361234};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW ECO:0000256|RuleBase:RU361234};
KW Reference proteome {ECO:0000313|Proteomes:UP000054924}.
FT DOMAIN 723..810
FT /note="E2 binding"
FT /evidence="ECO:0000259|SMART:SM01181"
SQ SEQUENCE 817 AA; 91736 MW; 011AAA88B3C8FF3D CRC64;
MKHFWHCLRV FLKYHSSQSS TDVVEAVQCA IRRGAIKTSF PDSLLNNLES IRGVHPCIYA
GFDPSSDSLH IGNLATSRLG DPSGRSVERD RLSLEEIQSN SQSIQFTLKS ILRNFEKIKI
SLNSTNVLST PAVLDNTDWY HQMNVLDFFD VVGRAFRLRH MMDKQCISER IHREGMSYAE
FSYQTLQAYD WLHLYEKFGC LLQIGGADQT GNIHSGHDLI RFFHNQSAYG LLVPLMLSST
GEKIGKSVGS SLWLSSSRTS SFVFYQYFLQ LTDKEANSMM KLFSFCSEAD LERILDDHCQ
QPEKRIAQRF LADQLTLLVH SESGLALAKR ITEILFDHRL HGIGDLDEND LNILCREVPG
VQLSRQALPI SAISLALKAG CFDDVNTAER TINQGGFHVN NFKITNPTIV SMNRWHCVRK
LLERSGPFAH PEFVPSVENI DLIGTCRVLV IGAGGLGCEL LKDLVMPFLD FETFMQKDIG
KSKAIVAAEA IERRLPFCSV TPHFCRIEEK PLSFYESFAV IVAGLDSISA RRWINRTLVR
LLRYDDKGEL DMASVIPLVD GGTEGFKGSV RVILPGLSPC VECLLELYPP PVQYQLCTIA
NTPRSPEHCI EYVKRIAWSE KHPFGDMEID GDNEAHIQWI YNEAVKRAGA FGIHGVTIRL
TKGVIKNIIP AVSSTNAVIA GRSSAMPLEN YMNFQDGEGI YMGAVLLERD ENCELCSRKP
ITLTFNENDT LENVCNVLKT DSRFEFTSPS ITYMHGTCRA LYVPSLPGFE NLSRENLTKT
LKELGLMNGE EIYVSDPSMK STLTFRLSIL TAAQIES
//
