ID A0A0V1P1E1_9BILA Unreviewed; 931 AA.
AC A0A0V1P1E1;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE SubName: Full=Protein arginine N-methyltransferase 5 {ECO:0000313|EMBL:KRZ90005.1};
GN Name=PMRT15 {ECO:0000313|EMBL:KRZ90005.1};
GN ORFNames=T08_12161 {ECO:0000313|EMBL:KRZ90005.1};
OS Trichinella sp. T8.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=92180 {ECO:0000313|EMBL:KRZ90005.1, ECO:0000313|Proteomes:UP000054924};
RN [1] {ECO:0000313|EMBL:KRZ90005.1, ECO:0000313|Proteomes:UP000054924}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS272 {ECO:0000313|EMBL:KRZ90005.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ90005.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JYDM01000061; KRZ90005.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V1P1E1; -.
DR Proteomes; UP000054924; Unassembled WGS sequence.
DR GO; GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:InterPro.
DR GO; GO:0016274; F:protein-arginine N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0140647; P:P450-containing electron transport chain; IEA:InterPro.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd00207; fer2; 1.
DR Gene3D; 3.10.20.30; -; 1.
DR Gene3D; 3.20.20.150; Divalent-metal-dependent TIM barrel enzymes; 1.
DR Gene3D; 2.70.160.11; Hnrnp arginine n-methyltransferase1; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR036010; 2Fe-2S_ferredoxin-like_sf.
DR InterPro; IPR001041; 2Fe-2S_ferredoxin-type.
DR InterPro; IPR001055; Adrenodoxin.
DR InterPro; IPR018298; Adrenodoxin_Fe-S_BS.
DR InterPro; IPR025799; Arg_MeTrfase.
DR InterPro; IPR012675; Beta-grasp_dom_sf.
DR InterPro; IPR035075; PRMT5.
DR InterPro; IPR035248; PRMT5_C.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR10738; PROTEIN ARGININE N-METHYLTRANSFERASE 5; 1.
DR PANTHER; PTHR10738:SF0; PROTEIN ARGININE N-METHYLTRANSFERASE 5; 1.
DR Pfam; PF00111; Fer2; 1.
DR Pfam; PF05185; PRMT5; 1.
DR Pfam; PF17286; PRMT5_C; 1.
DR PRINTS; PR00355; ADRENODOXIN.
DR SUPFAM; SSF54292; 2Fe-2S ferredoxin-like; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00814; ADX; 1.
DR PROSITE; PS51678; SAM_MT_PRMT; 1.
PE 4: Predicted;
KW Iron {ECO:0000256|ARBA:ARBA00023014};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00023014};
KW Methyltransferase {ECO:0000256|PROSITE-ProRule:PRU01015,
KW ECO:0000313|EMBL:KRZ90005.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000054924};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PROSITE-ProRule:PRU01015};
KW Transferase {ECO:0000256|PROSITE-ProRule:PRU01015,
KW ECO:0000313|EMBL:KRZ90005.1}.
FT DOMAIN 384..549
FT /note="PRMT5 arginine-N-methyltransferase"
FT /evidence="ECO:0000259|Pfam:PF05185"
FT DOMAIN 553..752
FT /note="PRMT5 oligomerisation"
FT /evidence="ECO:0000259|Pfam:PF17286"
FT DOMAIN 835..910
FT /note="2Fe-2S ferredoxin-type"
FT /evidence="ECO:0000259|Pfam:PF00111"
SQ SEQUENCE 931 AA; 105530 MW; 355228AE269D3F4B CRC64;
MSGKQNSDRF ANLMKTEVSN RFGTNEILMK YSTKTEDVYS LPGYLLQLEN KNIDFAVIAV
ENPRALHSTE STTKDNCPLL SIPDIIMKTR NWSRLVVGEF PPVKYEPHEE DEIQCFIKAR
TMQLEYANYL GLSAMIVSFT QESLAPLAHV LNHFFLGTSL LKKQGEDGKK CSSDQNEFCR
SCEADIAVVP RFGLFTLGTI ASGQGPGFTC RLALIVVSEI QAVHVGNASV GHCHRRERFL
RFEGRCVGDS HSQYGTRRHR VGCILSLVRF VACIRSKPVI WCRLPLTWNR IDETADDAWH
LYHQLRTACG NDGLENRSAT SPGGDLPTVS EFHRQLLSIL FARTSRAILE FDSEQLDTIP
VNEYSFCVRN LYKNQRVLPM EKNSSVMRSY RDYLQLPLQP LFEDLSAATY EVFETDSVKY
MQYEMAIKEA ISDKISGNDV PFFNVIVCGA GRGPLVTAVL KALEHFAIPA FQLIAVEKNI
NAVSTLDHLN KTKWNRKVHI VHSDVRKFKP PAKADIIVSE MLGSFGDNEL SPECLYEAMK
FLKPDGVCIP QFYQSYLSPV HAPKLHYNAA QYRKQVEYNV NIINLLNERM LWNVDMLSIL
LLHLSLTTQS HYFHSLIKLD SERRLTCATY INVAMLKGDG KMHCNAKPKQ KNFYKVLKFR
SEIDCELSGF LGYFYCILYK DHALSILPSN HTPNMRSWFS MFFPLVTPVM VKAGAEIEIH
FWRNTGHGKV WYEWWLAKPT VLPVQNPNGR SWSFALSFLS YFICSSILVV MHSGGDGFHF
ALSVKLTHSN KVLYFKNAVP QVKAGFRVVQ NATAEFPVDR IAVTFLTSHG DQFKAYGKIG
DTLLDMVFNE NIPLDGFGIC EGTCSCSTCH VILKREQYDY LPSPREDELD MLDLAYGLTD
TSRLACQIVL TEQLDGMEVV VPGLPDATQF H
//
