ID A0A0V1P3Y6_9BILA Unreviewed; 912 AA.
AC A0A0V1P3Y6;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Fibulin-1 {ECO:0000256|ARBA:ARBA00021554};
GN Name=fbl-1 {ECO:0000313|EMBL:KRZ91023.1};
GN ORFNames=T08_11130 {ECO:0000313|EMBL:KRZ91023.1};
OS Trichinella sp. T8.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=92180 {ECO:0000313|EMBL:KRZ91023.1, ECO:0000313|Proteomes:UP000054924};
RN [1] {ECO:0000313|EMBL:KRZ91023.1, ECO:0000313|Proteomes:UP000054924}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS272 {ECO:0000313|EMBL:KRZ91023.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the fibulin family.
CC {ECO:0000256|ARBA:ARBA00006127}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ91023.1}.
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DR EMBL; JYDM01000049; KRZ91023.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V1P3Y6; -.
DR Proteomes; UP000054924; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0016504; F:peptidase activator activity; IEA:InterPro.
DR GO; GO:0030198; P:extracellular matrix organization; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 7.
DR Gene3D; 2.10.25.10; Laminin; 10.
DR InterPro; IPR000020; Anaphylatoxin/fibulin.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR017048; Fibulin-1.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR PANTHER; PTHR24039:SF48; FIBRILLIN-2 ISOFORM X1-RELATED; 1.
DR PANTHER; PTHR24039; FIBRILLIN-RELATED; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF07645; EGF_CA; 7.
DR PIRSF; PIRSF036313; Fibulin-1; 3.
DR SMART; SM00181; EGF; 10.
DR SMART; SM00179; EGF_CA; 9.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF57184; Growth factor receptor domain; 3.
DR PROSITE; PS01177; ANAPHYLATOXIN_1; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 5.
DR PROSITE; PS01186; EGF_2; 4.
DR PROSITE; PS50026; EGF_3; 4.
DR PROSITE; PS01187; EGF_CA; 2.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Reference proteome {ECO:0000313|Proteomes:UP000054924};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..912
FT /note="Fibulin-1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5006883926"
FT DOMAIN 425..467
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 468..511
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 512..552
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 553..597
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
SQ SEQUENCE 912 AA; 101663 MW; DFF6807F8831165D CRC64;
MSNLPMLNLL LLLLLFYQQH VVEANQSSLA ECCLEGKKAY AISKQCTKTT VEKIDQAGFC
PRVASICCLV AFYETKCSEG KSIALAGDSC EALDAPGREQ TKECCECCSL AKEMKKQGKQ
CNAPVDFSAN CKAVFDQCCR YESAASRDEQ SNLQTDFAEF TASVSSTTVG LDLSEQCDEE
EEKFCEQQCR RVPGQKSISC SCRAGYMLNA DGRTCSDVNE CEENPPPCDV VSQICENTIG
SFRCSCMNGF AWNETTNLCV DIDECLLFRD NCIAGQRCIN TIGSWRCIRT MSCGTGYYLD
SESDSCVDID ECALGTHNCG PGFTCRNTHG SFRCERRFCP SGQQWNSTAK RCVTISGCSH
GFYLASDGSC QDISSNVDVN ECLTPGTCLP NQHCENTHGS YYCKDLPRAC APGYQLNPVT
SVCEDIDECM KGTHTCPNVE SCVNSIGGYH CECRSGFRFN SVIKKCEDIN ECQNRSSVLC
STHGSCVNTV GSFHCVCDPG YELSSDGRQC VDVDECRTGT AQCEHRCVNI PGSYQCVCER
GYSLGVDGRS CVDIDECKMW NTQGTAMCMG KCINTAGSFR CECPPGFRLN SDSRTCEDID
ECQQGLCSKD DDICVNLYGG YRCHQIICPQ NYQRDLRFKN RCTRKTLFCL PSDRDCMNAP
MSILYNFIAL TNELRFQDFG MNALPLITFN GPVNAETSVQ YELQLDRVVT LGSKTVKPAT
RASFSVQKLI TKPNAAVLNL IEPLQGPQQV DLDLIMHFRH AGNFGGRSLS KIVLHVSEYK
ENHFSFSVRD GYTCWKKCNP LDIGCLANRT YSISYQFIAL PEMSPRLKGP LEISRVYPEQ
ASHRRWPLRV QYSIIDNPSR RYDVQQQDNT GIIYMKYPIT KKTNEMIQLE MKIYSSTNVL
TEQNYAYISV FS
//
