ID   A0A0V1P8K6_9BILA        Unreviewed;      1121 AA.
AC   A0A0V1P8K6;
DT   16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT   16-MAR-2016, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=Cullin-2 {ECO:0000313|EMBL:KRZ92545.1};
GN   Name=cul-2 {ECO:0000313|EMBL:KRZ92545.1};
GN   ORFNames=T08_13232 {ECO:0000313|EMBL:KRZ92545.1};
OS   Trichinella sp. T8.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC   Trichinellida; Trichinellidae; Trichinella.
OX   NCBI_TaxID=92180 {ECO:0000313|EMBL:KRZ92545.1, ECO:0000313|Proteomes:UP000054924};
RN   [1] {ECO:0000313|EMBL:KRZ92545.1, ECO:0000313|Proteomes:UP000054924}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISS272 {ECO:0000313|EMBL:KRZ92545.1};
RA   Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT   "Evolution of Trichinella species and genotypes.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the cullin family.
CC       {ECO:0000256|ARBA:ARBA00006019, ECO:0000256|PROSITE-ProRule:PRU00330,
CC       ECO:0000256|RuleBase:RU003829}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KRZ92545.1}.
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DR   EMBL; JYDM01000033; KRZ92545.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0V1P8K6; -.
DR   STRING; 92180.A0A0V1P8K6; -.
DR   Proteomes; UP000054924; Unassembled WGS sequence.
DR   GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR   Gene3D; 1.20.1310.10; Cullin Repeats; 4.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR045093; Cullin.
DR   InterPro; IPR016158; Cullin_homology.
DR   InterPro; IPR036317; Cullin_homology_sf.
DR   InterPro; IPR001373; Cullin_N.
DR   InterPro; IPR019559; Cullin_neddylation_domain.
DR   InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR11932; CULLIN; 1.
DR   PANTHER; PTHR11932:SF177; CULLIN-2; 1.
DR   Pfam; PF00888; Cullin; 1.
DR   Pfam; PF10557; Cullin_Nedd8; 1.
DR   SMART; SM00182; CULLIN; 1.
DR   SMART; SM00884; Cullin_Nedd8; 1.
DR   SUPFAM; SSF75632; Cullin homology domain; 1.
DR   SUPFAM; SSF74788; Cullin repeat-like; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS50069; CULLIN_2; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000054924}.
FT   DOMAIN          370..597
FT                   /note="Cullin family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50069"
FT   REGION          830..861
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        842..861
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1121 AA;  129052 MW;  349147013CBF8A08 CRC64;
     MSLRPQAFDF DSLWHKLRPC VEQVIAVQPV PPSLWNETVP ESHTMRLYKA VQTCLQAHVK
     LLYDEISNCC EDHLLEKYFE RWRKYHAGAK YLDRLFHYLN AQYVNKLKIT DSDLFYGRLF
     REENQVNTKF VGELAMDVWN EKMVRPLTDR LVALLLKEIK RYRNGVPVNT DVLSGVIHSF
     NDSENDDSGP ASEANTSEYY VDIAVRMLAT TTPSEYMQFV LEKIRQEEAR SERILHRSGV
     DKVQQICQEV LVNRHMSMFK SVAKEIVREE NLADLSNMYA LLSAKSSDLS FLVNEFESYV
     RGIGQHCMQN LKGDDLQVAQ QFVEEILAVF DKYGQIVKKT FKGDHEFSAA LDRACLAVIN
     HRNGSKDPAK AAEWLSKHID QILRKSTKPI VDSCIDFELT KAINILRFVD DKDLFHKYYS
     RSLANRLISG LSISIPAEET MIHKLKSCCG YEFISKFQRM LSDITLSKEL TNNFVNYLQE
     RVLGINVHMM VLQAGAWPLM QCQLKIPIPP VIENAITEFE QYYTRFFSGR KLSWMLQFSV
     VDVMLHYFHR RLMASVNLHQ LAILLCFENH DQLALEDLKI RSGIQDGGFD SNLQCLIDAG
     ILLRQSEKYD GQLRTKIILN KHLTSRRVKF RVNSPFFSDA FNKDLSAGRQ VHADLKVDRK
     LFIECTLVRI MKSRKLIKHE DLLREVMEQC VGRFVPEAEC VQNRQPEHRM EDIHCCVIGV
     QIKVDRPTFG LYYPARTFIQ TPLEKWHLLA VDNTICNQSE HRIRMRCLSV LLVTMFVSSK
     VQAHGIFDWL NFGQAGLSPV PLSTSGQVVD YARQGVNFLS FLKSLKPLTT SRRRAERRKH
     RQRAKPLSEQ APDDETDLHT DDHRPLLLTS RRRANMPLYK AAPTLAESAQ NFPGFGACLP
     NGTPFFNHIS PSILQNMLRI FPGAQNFMRK MLPATRVHPK KLMGKWYWVL MTPAALSRHC
     ATSDYHGLVL SRNGTGTFAT FDSFRDGSSY GLPKFGFGYG VISNDNQALV YMQSDPCPYQ
     VVYTSSDYDE DDYNTETQYN YVVLSNWARY PVIALAKNVE QFMMSDFEQL KNDLNRDGLH
     NKVTELLKST ELADWSVCEA KQTLKQMATQ LIQNLLSKSS L
//