ID A0A0V1PB90_9BILA Unreviewed; 728 AA.
AC A0A0V1PB90;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Glutamate-gated chloride channel {ECO:0000313|EMBL:KRZ93523.1};
DE Flags: Fragment;
GN Name=GluClalpha {ECO:0000313|EMBL:KRZ93523.1};
GN ORFNames=T08_9672 {ECO:0000313|EMBL:KRZ93523.1};
OS Trichinella sp. T8.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=92180 {ECO:0000313|EMBL:KRZ93523.1, ECO:0000313|Proteomes:UP000054924};
RN [1] {ECO:0000313|EMBL:KRZ93523.1, ECO:0000313|Proteomes:UP000054924}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS272 {ECO:0000313|EMBL:KRZ93523.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
CC {ECO:0000256|RuleBase:RU000687}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ93523.1}.
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DR EMBL; JYDM01000025; KRZ93523.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V1PB90; -.
DR STRING; 92180.A0A0V1PB90; -.
DR Proteomes; UP000054924; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005230; F:extracellular ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR CDD; cd18993; LGIC_ECD_GluCl; 1.
DR CDD; cd19049; LGIC_TM_anion; 1.
DR CDD; cd19062; LGIC_TM_GluCl; 1.
DR Gene3D; 2.70.170.10; Neurotransmitter-gated ion-channel ligand-binding domain; 1.
DR Gene3D; 1.20.58.390; Neurotransmitter-gated ion-channel transmembrane domain; 2.
DR InterPro; IPR006028; GABAA/Glycine_rcpt.
DR InterPro; IPR044721; GluCl_TM.
DR InterPro; IPR006202; Neur_chan_lig-bd.
DR InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR InterPro; IPR006201; Neur_channel.
DR InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR InterPro; IPR038050; Neuro_actylchol_rec.
DR InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR NCBIfam; TIGR00860; LIC; 1.
DR PANTHER; PTHR18945:SF898; GLUTAMATE-GATED CHLORIDE CHANNEL; 1.
DR PANTHER; PTHR18945; NEUROTRANSMITTER GATED ION CHANNEL; 1.
DR Pfam; PF02931; Neur_chan_LBD; 1.
DR Pfam; PF02932; Neur_chan_memb; 2.
DR PRINTS; PR00253; GABAARECEPTR.
DR PRINTS; PR00252; NRIONCHANNEL.
DR SUPFAM; SSF90112; Neurotransmitter-gated ion-channel transmembrane pore; 2.
DR SUPFAM; SSF63712; Nicotinic receptor ligand binding domain-like; 1.
DR PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|RuleBase:RU000687};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU000687};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU000687};
KW Reference proteome {ECO:0000313|Proteomes:UP000054924};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000687};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU000687};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU000687}.
FT TRANSMEM 316..338
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT TRANSMEM 379..402
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT TRANSMEM 523..547
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT TRANSMEM 588..611
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU000687"
FT DOMAIN 96..294
FT /note="Neurotransmitter-gated ion-channel ligand-binding"
FT /evidence="ECO:0000259|Pfam:PF02931"
FT DOMAIN 321..412
FT /note="Neurotransmitter-gated ion-channel transmembrane"
FT /evidence="ECO:0000259|Pfam:PF02932"
FT DOMAIN 530..664
FT /note="Neurotransmitter-gated ion-channel transmembrane"
FT /evidence="ECO:0000259|Pfam:PF02932"
FT REGION 69..92
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KRZ93523.1"
SQ SEQUENCE 728 AA; 83255 MW; C339192EE2BED255 CRC64;
LNTLTSAKIE ETMKPTTVDK FPSTDYGKIY GRFLLTISLL SMWLNFTLSH PRDSLTTWQG
RDIKGMDFQN RTKRSRRGKI GERREEETTK EKLSEQDIIQ KVMDGYDWRV RPRGLNASIP
EQCEVLLLDT GGPVIVNVNI MMRSISKVDD VNMEYSVQFT FREQWVDSRL AYKNMVSSGV
AMPKFVVLTP NDQSQQVWMP DTFFQNEKEA RRHMIDKPNV MIRIYPDGEM LYSVRLSLVL
SCPMSLEYYP LDRQTCLIDL ASYGYTTEDI KYEWKEDGPV QLKDGLKNSL PSFELQDVTT
GFCTSKTNTG AREFSYYLLQ LYIPSFMLVI VSWVSFWLEK ESVAARVTLG ITTLLTITTQ
ASGINANLPP VSYTKAIDVW IEVCVAFIFC ALLEFALVNY AARKDNIEAM NRAAYSSSKM
VQFGYKNFAI APFKEMDESC IQDDIYQFDV LQRAFRLSHI TADSPYYISS PTNSKIWNGL
CRKGQDELTL LLGLFSQLDS LLSILSTGEY SCLRTILTLK REYSYYLITL YIPSFMLVVV
SWVNFWIDKD AVPARVSLGV TTLLTMTTQA SGVNAKLPPV SYTKAIDVWI GVCLAFIFGA
LLEFALVNYA GRVEFLEKER RKQKVNLLTD NRWLPTVALP FMMQQSSSAA NPAGTFMQTR
QSTQIPQMQR QMPAADGFSI EAMCPECKAE QSEKKKVHDW EKEWIIMAAF MVRKVQGTVK
EDRCHVYS
//
