ID A0A0V1PDD7_9BILA Unreviewed; 1408 AA.
AC A0A0V1PDD7;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Cyclin-G-associated kinase {ECO:0000313|EMBL:KRZ94243.1};
GN Name=Gak {ECO:0000313|EMBL:KRZ94243.1};
GN ORFNames=T08_5404 {ECO:0000313|EMBL:KRZ94243.1};
OS Trichinella sp. T8.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=92180 {ECO:0000313|EMBL:KRZ94243.1, ECO:0000313|Proteomes:UP000054924};
RN [1] {ECO:0000313|EMBL:KRZ94243.1, ECO:0000313|Proteomes:UP000054924}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS272 {ECO:0000313|EMBL:KRZ94243.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ94243.1}.
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DR EMBL; JYDM01000019; KRZ94243.1; -; Genomic_DNA.
DR STRING; 92180.A0A0V1PDD7; -.
DR Proteomes; UP000054924; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0009982; F:pseudouridine synthase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0001522; P:pseudouridine synthesis; IEA:InterPro.
DR CDD; cd06257; DnaJ; 1.
DR Gene3D; 2.60.40.1110; -; 1.
DR Gene3D; 1.10.287.110; DnaJ domain; 1.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR Gene3D; 3.30.70.660; Pseudouridine synthase I, catalytic domain, C-terminal subdomain; 1.
DR Gene3D; 3.30.70.580; Pseudouridine synthase I, catalytic domain, N-terminal subdomain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR001623; DnaJ_domain.
DR InterPro; IPR036869; J_dom_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR InterPro; IPR020097; PsdUridine_synth_TruA_a/b_dom.
DR InterPro; IPR020095; PsdUridine_synth_TruA_C.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR InterPro; IPR014020; Tensin_C2-dom.
DR InterPro; IPR020094; TruA/RsuA/RluB/E/F_N.
DR PANTHER; PTHR22967:SF105; CYCLIN-G-ASSOCIATED KINASE; 1.
DR PANTHER; PTHR22967; SERINE/THREONINE PROTEIN KINASE; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF01416; PseudoU_synth_1; 1.
DR Pfam; PF10409; PTEN_C2; 1.
DR SMART; SM01326; PTEN_C2; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF46565; Chaperone J-domain; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF55120; Pseudouridine synthase; 1.
DR PROSITE; PS51182; C2_TENSIN; 1.
DR PROSITE; PS50076; DNAJ_2; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Kinase {ECO:0000313|EMBL:KRZ94243.1};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000054924};
KW Transferase {ECO:0000313|EMBL:KRZ94243.1}.
FT DOMAIN 34..310
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 539..678
FT /note="C2 tensin-type"
FT /evidence="ECO:0000259|PROSITE:PS51182"
FT DOMAIN 1004..1064
FT /note="J"
FT /evidence="ECO:0000259|PROSITE:PS50076"
FT REGION 884..906
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1408 AA; 159103 MW; 2C5FC991C077F618 CRC64;
MELFRNALNY INSSSDQSDD DFVGQTVVIG SERLRVRQRI AEGGFGFVYE TAAENGNQYA
LKRMFAGDKE SYKTINREIC ILKSVSGHEN IIQFVAAASE NSQAARRYEF LILTELCTGG
PLLNHLRGRQ KPFEMCEIYP IFYQVCKAVK HLHCRSDPVI HRDLKIENLL LDRKGTIKLC
DFGSATTECY YPDSSWSVQK RDALAEELKK FTTPMYRAPE MLNLFDDYPI NQKVDIWALG
CILYYLCYME HPFEDSATLR ILNAKFNFPE NDERCAIAHP LICNLIQPNP NNRYDIVALI
EQLRQSAEVY GIDLQARADL FPTNVKSVST PVMENNSSTT NMLESLKGQA GSILKNIRDT
STRMRNSIQN NASKVELNSL TSRLMFLLVP VHGTDAGIRS NVARLQHTLQ LRHGHHFKLY
SLTYRTYVDD LFGNQAMHCI FADGAAPSLD LLLTACKTMY NWLEKDSRNV CVVHCSNDVG
NGSCIMGALL NFCGVFSNSV ETVDFFKKDP SIPPMSPSQI KYIDYLNTVK KWPAVYPQPI
TMHLKNLSVK PLPLFNRLKS GCRPFVVIYA NNRKVFTSGD NFESIPLYEV KDCSGFSVPL
DVTVHGDVTV VLCHARSTLG DRMQGTVTAV RMCQFQFNCG FVDCSVDQMT MNMQNLDFVD
QGDKYPKDFS VQLNFSALED RRTGCHSVDL HGIFDIVPNA FKVVFSTENE LQRFIYQYSS
VVQTYSNYSY FFLDQLIGII VETSTGKQPF QCDDGFQQSN KEKSSDDHEV ENDLHLLHIS
PFGETGVVER QPKPATDQHS NLLDLQYDTV DCCLLDSDSV STATGASNRR DLDTDQRHDL
VDSLLDADLQ YAGLSDPSAH DEAAKSTLAS STHVTRNYSS PLLNQAESSR PVAPVPRSTT
IFGRPGTART TTTVSITATT MPTSERNKLQ VCDKHFEDLL TSQGFTAASS SAKTLQSLAS
MRRDQENLLL TEDEIKIRSW IEGKDRNIRG LLCSLHTVLW QGNEKWEEIG MAELVTAAQV
KKYYRKACLA VHPDKLVGTA HEQLAKLIFM ELNDAWSEFE KTAEMLLGKN MVECRAVCPS
LLINGSQSQP NQLTVQGVLE NVLAMILLSP LGEEPRWYFS SRTDAGVHAF MNTATVDLDP
ERDFDSDYLK SALNSMLTKL DMEIRINSCR RVSGGFCARR HALEREYLYR LAILKPEFES
DHHKQTNNTS TTQNAHHSLP LIEHRRAWAL SSAFNHERFR KAALMFQGSH NFASFMTNSV
GNLDRPTGIA TVKNISRLDI DFGKALMDSK HEPCSDFFNF FDVSFVSRSF LYNQIRRMMA
CMVAAAKHRI ELDDIEWLLN RPDPANWAKH HLTLAPAYGL YLKSITYDDK DFTEPHPLHC
RLQDDADEEM PYPLPMNVES LLNGNGDL
//
