ID A0A0V1PII0_9BILA Unreviewed; 1373 AA.
AC A0A0V1PII0;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 22-FEB-2023, entry version 17.
DE SubName: Full=Rho GTPase-activating protein 39 {ECO:0000313|EMBL:KRZ96038.1};
GN Name=nft-1 {ECO:0000313|EMBL:KRZ96038.1};
GN ORFNames=T08_15434 {ECO:0000313|EMBL:KRZ96038.1};
OS Trichinella sp. T8.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=92180 {ECO:0000313|EMBL:KRZ96038.1, ECO:0000313|Proteomes:UP000054924};
RN [1] {ECO:0000313|EMBL:KRZ96038.1, ECO:0000313|Proteomes:UP000054924}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS272 {ECO:0000313|EMBL:KRZ96038.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ96038.1}.
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DR EMBL; JYDM01000009; KRZ96038.1; -; Genomic_DNA.
DR Proteomes; UP000054924; Unassembled WGS sequence.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd04389; RhoGAP_KIAA1688; 1.
DR CDD; cd00201; WW; 1.
DR Gene3D; 2.20.70.10; -; 1.
DR Gene3D; 1.25.40.530; MyTH4 domain; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR000857; MyTH4_dom.
DR InterPro; IPR038185; MyTH4_dom_sf.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR PANTHER; PTHR45876; FI04035P; 1.
DR PANTHER; PTHR45876:SF8; FI04035P; 1.
DR Pfam; PF00784; MyTH4; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00139; MyTH4; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00456; WW; 2.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF51045; WW domain; 1.
DR PROSITE; PS51016; MYTH4; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000054924}.
FT DOMAIN 48..75
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 1010..1170
FT /note="MyTH4"
FT /evidence="ECO:0000259|PROSITE:PS51016"
FT DOMAIN 1181..1368
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 130..223
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 244..276
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 341..360
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 389..409
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 455..504
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 599..633
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 657..681
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 721..776
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 866..885
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 952..972
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 130..178
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 197..211
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 244..261
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 342..360
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 721..735
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 736..751
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1373 AA; 153105 MW; D78E238F44345A2C CRC64;
MADSQIEWVE IVEPQTREHM YANLITGECA WDPPPGARIK KTHENQWWEL YDQNTGRFYY
YNASTQKTVW QRPYNCDIIP LAKLQTLKQN TEARHRTSAA RQQHASPVQM ELRGNVVLYD
EPLFSVPNES INSPCTTASS LSPHSSRSST QTSTTTRRPE TKTVSCQTQT SPITSPKARK
RVNKTKGCQT ALSASHLVKK HSHRTGGGRS RSRSRRNVAI SAEPEDSIQE ALIVSLNKEK
RSADFRNTKE TANERPVENG IENDRPSAGS SLDRCSSSSC ADAATNSRRF DPMIGSMSSY
SLQMNNCCAD SHRINVEVGK FLRRHDSKLS SCHRVDELPP NQQFCKGSSS TPPRRRQLDQ
KQCKASASCL DSSSSFVRSF LAQNNSSTTI TTTTNTSTGT NTSNTKNAAV PVPAVRQSLK
LHSEQSQRSN LGNLSRQRSF DFACNFNQLR LHGRKDGTKL ESGSEDEEEE EDGDSTATTT
TTTANNNTDE HANEVDKEEE EMTVDDGQAE EIQLGEEVSE DKNSVMVMKN YGASNNTINA
AGGGGKSAKK VSLKTANVCH SKARVVPATA SMSGSPQIWQ AIDNSSTCTA GTAVWKSHDS
GIKSGDSGAR GDDSSSAASV ESPRFGHLDG SQSAGNVFKS SGTACKVAKF PVSLNRPVSP
NVNKIPQPQQ QQQQQQRQTT PRMGIAFVSS IAPAYEHVTK HLTYSQLHQQ FIVGDSIDQF
SEQEVEESSS SSSNDDSAPD DDDDEGLFAD DEEGGPPSPV SLSSQDDDDD DDDNAIDDKN
EVLVSQSCLS SKKYLLPTMG VSQRFFDPDD SRLRVIYDTP DTPSKESKSI TPHDCADPLL
LDSVLYRRRS SDAGNFSTPK LNATVGSCSN NSMAEEEEES GSTKRALKNV VEKPARSSMN
GFVSTAADLS PNQYRPQSVL MSGHQEHYLA PTNLIPNHSS TLNRLNKAEC TRTTTTSGPM
HHHHQQQQQQ QQLLRLKESD GVELYPHEYL NRHKKGLFGK RQSVQSMLSW TRAELKKPLI
MTVDKAVKKE AREIFKRIQA YMGDRKVKKS TITVDMLALD VCVRGWAKPA LRDEIFIQLC
KQTTENPRPE SVRRGWELMS ICLKFFPPSS QFTSYLDTYI CRYADPVLDL PEVSVSHYAQ
HCCKRLERIL RHGARRGLRK PTIEEVEQAR LQIFHPSMFG NTLDEVMVIQ RERFTGRKLP
WIQTTLSELV LQLNGAKTEG IFRVPGDIDE VNALKMRIDR WLLPPVADPH IPASLLKLWY
RELADPLVPD CLYQECIQTV DEPLKSCEIA DRLPSINRLV LAYLIRFLQI FIRPENVAHT
KMDSSNLAMV MAPNCLRCQS DDPTVIFDNT RKEMTFLRNL MEHYDTSFVD GLL
//
