ID A0A0V1PIL0_9BILA Unreviewed; 4415 AA.
AC A0A0V1PIL0;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE RecName: Full=HECT-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012485};
DE EC=2.3.2.26 {ECO:0000256|ARBA:ARBA00012485};
DE Flags: Fragment;
GN Name=HUWE1 {ECO:0000313|EMBL:KRZ95970.1};
GN ORFNames=T08_8160 {ECO:0000313|EMBL:KRZ95970.1};
OS Trichinella sp. T8.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=92180 {ECO:0000313|EMBL:KRZ95970.1, ECO:0000313|Proteomes:UP000054924};
RN [1] {ECO:0000313|EMBL:KRZ95970.1, ECO:0000313|Proteomes:UP000054924}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS272 {ECO:0000313|EMBL:KRZ95970.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.26; Evidence={ECO:0000256|ARBA:ARBA00000885};
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SIMILARITY: Belongs to the UPL family. TOM1/PTR1 subfamily.
CC {ECO:0000256|ARBA:ARBA00034494}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00104}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ95970.1}.
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DR EMBL; JYDM01000009; KRZ95970.1; -; Genomic_DNA.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000054924; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd00078; HECTc; 1.
DR Gene3D; 3.30.720.50; -; 1.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR InterPro; IPR010309; E3_Ub_ligase_DUF908.
DR InterPro; IPR010314; E3_Ub_ligase_DUF913.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR InterPro; IPR025527; HUWE1/Rev1_UBM.
DR InterPro; IPR009060; UBA-like_sf.
DR InterPro; IPR003903; UIM_dom.
DR InterPro; IPR004170; WWE-dom.
DR InterPro; IPR037197; WWE_dom_sf.
DR PANTHER; PTHR11254:SF67; E3 UBIQUITIN-PROTEIN LIGASE HUWE1; 1.
DR PANTHER; PTHR11254; HECT DOMAIN UBIQUITIN-PROTEIN LIGASE; 1.
DR Pfam; PF06012; DUF908; 2.
DR Pfam; PF06025; DUF913; 1.
DR Pfam; PF00632; HECT; 1.
DR Pfam; PF14377; UBM; 3.
DR Pfam; PF02825; WWE; 1.
DR SMART; SM00119; HECTc; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR SUPFAM; SSF46934; UBA-like; 1.
DR SUPFAM; SSF117839; WWE domain; 1.
DR PROSITE; PS50237; HECT; 1.
DR PROSITE; PS50330; UIM; 1.
DR PROSITE; PS50918; WWE; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000054924};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104}.
FT DOMAIN 1815..1891
FT /note="WWE"
FT /evidence="ECO:0000259|PROSITE:PS50918"
FT DOMAIN 4110..4412
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT REGION 544..563
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 809..869
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1493..1533
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1611..1643
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2473..2586
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2783..2839
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2981..3021
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3218..3239
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3334..3360
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3451..3500
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3784..3859
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3980..4010
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 842..869
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1493..1527
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1612..1637
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2473..2569
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2572..2586
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2783..2805
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2821..2835
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3334..3349
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3451..3494
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3784..3808
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3809..3859
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KRZ95970.1"
SQ SEQUENCE 4415 AA; 495357 MW; F2DB0BB775DE5375 CRC64;
LPVRRLCIQL AVFADNCNST SRNYNIICSL LVSDFFHVMY VTLVPMLSVQ GYLNKAVNCD
NSEEELKMKI DVTSVRKQTA QAPSDCLKQI SEILSADESS IADFLINVKT WSWSKSELCH
WIPVLNRFDD FLAQACVRKE DNEWRLHCDQ RQEKLVIGIL QFTALLFENT FSRDIYNSME
HIVVLLESSS ISILAATLNL INVFSKRSTF LSRLSKDLHE ELKARMLAIV ETWGGPEFGL
TLSICCRRDV EIPSALTTLT FDVDDDEINL TNPKNDNDKG SSRRTIRFVE VHKQKRTPAQ
WMQELISKGI TLPADKKFLL FHRLRVAYAF GNFETRLLMV ICRLKAVAIS VYISSFTDFE
YRLLNTGLVI QMLDVLKLPD LPELMAVRAE VFRTLGTFFS HVRTGIWTEV VDPLGLTFFH
GFLPTLTRSC VNELLEHSSN SPVKYPHYFS TALFSFLYYL AKYDRNGAQA LTTSGTVEVL
LKVVSSSAAR GEGLTFVTRA VRIIEMTLTP TDSMTFQNLN GIQTFIHRLS DEIDHCRRAL
GHPLSSSDDS SIHAPGTSSS NVLQQSNDAL KGKPLPFAIS SDAQTLSFQS AALIKSLLSF
MKKIIQDPQF SESVRHIMDS NFSNCLSHII QNSLFYGPSL FLLGKLRLGT MSCVASFILQ
EPSQLSQLQE RGLTTEILEA LFRNEIPTSR EIVSSLPNIF SALCLNERGV SQFLSYSPFK
TLFTLLISPN YLNALRRVRS LEDVNNTAFI LGSMIDQLLR HQPRLKSDAI HAVVEVCICY
HVDADDRLLR QLAVMCKCRG VTCAEEADVS GRNRRRPQFP TEHPLPFSRL GNNDSDQSDP
DDSESGPVPS LVLSSPNGNS SENSSNRNDL SNEQVVPLVD YFENVLKFLH GLFNRNQNDE
HARLFLNLGG MYSLVDLIGC GNIPVDYMGG QLYYLLATIC RQLYVVTHNP LVFEGIFSSA
LDRARAVKNI FSYHSKSADR PDVRHSVLVK HFPDGVQTVE STVYSSSQFS AVFDLFNHIY
VLSCMLTTIF QQGENRAIIL KTVNEFPLVE TLVKVHLVLL LEMGCVASAT EESVRRNGPV
SVSQFMKDGH TLDAKSFPGA NDILSMQVLR RAVMNELPND STTCNHSKKS TALRCFPMEL
YFCERLILQL KFFFGRLAKL TQTNRPGIPG RRFAQFADRT AVTVEGDKAM THLVKTLCSI
NKVTISSKNL DAWYLKKNFF FVLSFRFIIF TSILHFYRSS LYICTATLEL LSDIFLDYEQ
LHVTPVVEFF QRVSTFQMLQ NLSNIVDSDR LWLGKDKYGK SCGSDARGFI SDVLVLIDKL
IRAKHFDHRN ESEGRSSFPN TPHPVIISSL SKFMYKTLIS LWHRLPSSPK LKSDESLSAL
SRITLHALRY ESRKIEERKS SEKSSVVQAE VEVIPEISQI VNPVHLQQLM DVGFSQQLAT
EALSRLPNVD QAAEYCLYAS SNRALVQQDN QADVGDDEEQ LRQAIALSLM TMSSPGGEQQ
QQRPPETQAA AAGSSGSSSS NQRGVDFVPE IRQQPSREEI NATIENLLHN TGTQMMDIAE
SSLASIGRFP PLFEQIERQL EMEMEMEMEF EMEPRTSGRN ILAPVISAGS NAAQMPPASS
SDKTQLSKQA SKTASQSAVP KEHDERSEAF LRFAEKDLLP SSILLLKRSP KLAAALTPLF
SIVITLFGFK SVKTYLLIFC NRLCSVVTAT MIEIEQMMEV HSEADRSATI PSDSRFEFEE
LSTLLNLLHR LFVQFQVPMA IMLHETKLLA KFEEFIVLIG LKSKNTTFLS FMSKRSQAWL
AYILRILELH VYTCEVVDRL LAIPKCRNYI WKFWDRQWYC YSPSVNRKIN DAFMGGDQYV
YFSQGRRTYR IDFFLMIQFC HETNIIRKVI CLRPENSDGN SADNNTPVTY CYHPFLNYVD
MATFKKEDLG SCDKEILLNV AVEMIGSSVH AETLRGILRI ILLLTRDHSR TKYIVFHGTI
KRLFALDESQ KFVGVEDMVM LLLRHIIEDP DYLQNLMEKI IASLLTGHMA ISNYTSTELK
EFSCMLCLLE PFACRDMNLF AKAFKRTAKI NIAANENRSA AAPSTVCLEL SCAAPSVVNS
RSPHLKPAAF ELIKTLLEYI MTKQKSSVSS VVKDSRAEMK PSSSRLFQRE STEGESQLVG
SLLFPKPLVM LYLAEIIQCY PDAASVVVNF RLNESGSLNT SDNRSPLAHI LDVLIEGEFE
EWKCKGQTFV DGVKAVFGSL SACVHCEESQ AAVVSEIKAA LARALALNNN ERKHKILDNL
MSLLCHIVEV CPLSEVQIPK DSKLPPPQNT KFKSILRWFV KKRLLVDLAR IPHSLDLSDA
QSVLTVNCML KALDEISRQH FYPSRSRSIG TPAINYLTSN GQAGRRSLIR ISETVDSAGH
DYVFLNLASA NGRGNSLFTV FDSEFPTLRS LDGDFSSDGF FDREDTIEVA PEPPQGNGND
NFPEFIVHNL AADDDEEDDD EDDEDDEDED VEEEEIDIND EVGEDEEEEE ADHGDDHEVG
EEEEEEEADN DDSEYEAVED DVNEEDDDDD DDDDDDDDDD DDEDEDDELL NSFRNTSYVE
QNNNNTISSN DLAGSIGTLG DLLRQTLSSN SNGVRDVINQ LSSEGREERW HHDVPSITIE
PDVEFGYRTL GRNRGGQHRS GLPRIVQLNR QSAFRIRVTE PMPIVDTDDI FWRDFFSEAV
RPAERFVMFQ RSLTDTLRSI NFGSRLNVTN SSEANMPMTT EICGFFTRIM QEGSLLEMDS
TYLAWLAVRE DILKALEKRR DDELSKKQAE ASSAADSEDK SKKSESNNTS GTASQDEPGR
LRAVVRGDHP RDSDNSSSQL AESFINQDRN DDIEQEISWV SVTDGQVLFE GSRQQVVANS
QRLFQQQQAE QEQQPAANND ANPEIPIVPD NAFLEALRQA QEHFETPGRL DMPDPDALQE
ACNMLIMTGG LAETPEEQQN LRLDLLSESD LVQGRVAAEE QQQLQQQEPQ ENVESNADAA
VAADATTAAP ETAETEELTE EQRRIRDILG DTPIPEGVDR AFLAELPENI RAEVIAEQWR
LLRLQQQSRS AEGTDGSAPP AISMDFLVAL PPELQEEVIA QHRISSQQQN NPDGQMDLAT
FFETLPAPLR RQILSDADES QMAFFPSHIA AEARHIQLTF NNRETGRPRH YHVVRTGRNG
QRGDNSVRPR HGIRLARRPV PADMRSLRQQ LANWNRDTPS YTRTQFGGHT GSKSASTNTT
LSTRSSALFD RESLTCLLVL LFVDDSRLST ARLTRILRTV CAHPGTREWL LRALVSILQR
TWMSLDLVGG STLGGVRPSD PEFGDLSNYT FSTTPSRSTV VTRSSHRRNE AAGTAGGLHL
SSANNENKGW LSMTMTSKLG NCVEVFRISK PTASGGKRAL LFPQLTPVLL HPLVVPAVST
AVINTIAAIA KSYSHSFFPQ LRKLLNSQSN AASTSDGASA STAEAGSTAQ QSGAARQGDE
QQPQSASKTP TLRRRSSSAV DRMRSDFWDI LTKLNNPSSA NSRTKHSPKI VSFGFPDTTA
QCGVEDSLFG QLVLFLRHPV IVERQGLQSI LLSTLQHVTS ASLAQISDTI LDQGVFLEEQ
LKLLIDVLVR DSSSGDNRND ARLILVRCAA ALGPATRRRI FELLFEAARE LAGALRKELI
VLLEEMRSLK NNEPGTSAQF VAGSSSSSGS ALLPARGRMI DRFTGTTLVV SSTSPAKAPN
FACSQELQCP SMELLSKKNS MQTCLLRVIN SILSMKHSMK KFDERDANFE QDVTSFDFEL
HDSEEVIDDS DMSAGDRVRD RRNGSSSQEE GRQENTASVE PAPATTTTAG TDASSTTVTA
SSAATPTTTT SDESSTATVA APVTPVASAG VEVSDSNAPL GTVTSTSITA LSSGDGSSNN
ELVGEEAQRP VFELEAQPLT VSMQVDNLWD LLSECLTLLD ESADPHAVLI LQPAVEAFFI
IHGDDKRHMN ELCTLLQSST RPDSDTLTES SASNSVQPFS DMTVSSSDAM KSSDPHFRNL
PLDVQMFIRF AEKHRTVLNQ IIRQSKTPLN TGPFSVLINY TRILDFDIKR RYFRLELERV
DQTFRADDTP VRVKRDRIFQ DSFRELFRLR PSEWKSRFYI LFDGEEGQDA GGLLREWFSV
ITREIFDPNY ALFMTASGDS VTYTINPSSY INREHLQYFK FIGRLIAKAI YDNKLLDCYF
TRAFYKHILS KPVKYTDIES EDPSFYQSMV FLLENPVSTL GYDLTFSLEV EEFGVREIRD
LKPEGRTVLV TDANKMEYVR LVCQMKMTGA IRQQLNAFLE GFYDIIPRRL ISIFNEQELE
LLISGLPIID IDDLQQNTEY YKYNKNSLQI QWFWRAVRSF DHAERAKLLQ FVTGTSRVPL
QGFAALPGMH GAQRFQIHRD DRSVDRLPAA HTWYV
//
