ID A0A0V1PMA2_9BILA Unreviewed; 1307 AA.
AC A0A0V1PMA2;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=Tyrosine-protein kinase receptor {ECO:0000256|RuleBase:RU000312};
DE EC=2.7.10.1 {ECO:0000256|RuleBase:RU000312};
GN Name=Alk {ECO:0000313|EMBL:KRZ97317.1};
GN ORFNames=T08_11608 {ECO:0000313|EMBL:KRZ97317.1};
OS Trichinella sp. T8.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=92180 {ECO:0000313|EMBL:KRZ97317.1, ECO:0000313|Proteomes:UP000054924};
RN [1] {ECO:0000313|EMBL:KRZ97317.1, ECO:0000313|Proteomes:UP000054924}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS272 {ECO:0000313|EMBL:KRZ97317.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001171,
CC ECO:0000256|RuleBase:RU000312};
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
CC kinase family. Insulin receptor subfamily.
CC {ECO:0000256|RuleBase:RU000312}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ97317.1}.
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DR EMBL; JYDM01000004; KRZ97317.1; -; Genomic_DNA.
DR STRING; 92180.A0A0V1PMA2; -.
DR Proteomes; UP000054924; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IEA:InterPro.
DR CDD; cd00112; LDLa; 1.
DR CDD; cd06263; MAM; 1.
DR Gene3D; 2.60.120.200; -; 2.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR000998; MAM_dom.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR InterPro; IPR002011; Tyr_kinase_rcpt_2_CS.
DR PANTHER; PTHR24416:SF604; RECEPTOR PROTEIN-TYROSINE KINASE; 1.
DR PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR Pfam; PF00629; MAM; 2.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00192; LDLa; 1.
DR SMART; SM00137; MAM; 1.
DR SMART; SM00219; TyrKc; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 2.
DR SUPFAM; SSF57424; LDL receptor-like module; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS01209; LDLRA_1; 1.
DR PROSITE; PS50068; LDLRA_2; 1.
DR PROSITE; PS50060; MAM_2; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
DR PROSITE; PS00239; RECEPTOR_TYR_KIN_II; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Kinase {ECO:0000313|EMBL:KRZ97317.1}; Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Phosphoprotein {ECO:0000256|RuleBase:RU000312};
KW Receptor {ECO:0000256|RuleBase:RU000312, ECO:0000313|EMBL:KRZ97317.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000054924};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000313|EMBL:KRZ97317.1};
KW Transmembrane {ECO:0000256|RuleBase:RU000312, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..30
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 31..1307
FT /note="Tyrosine-protein kinase receptor"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5006884361"
FT TRANSMEM 817..840
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 250..435
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 903..1179
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT BINDING 937
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1307 AA; 144453 MW; E7A6C7A09A63F0A6 CRC64;
MRTPQLGSSF CNLLLFVITL CVEMRREAAG AICNFESPCQ WNFEPPSSEN GFRIVSGTEI
SGQSGHYAYF GTSNNEETVA KIVSPFFQHT ATHCKLKFRY RLHGMPRTEL IVVLETMPDR
LNTTRPPMQL KMFPAKIGVV SKWSEEMVSI GQFPWPMRIR LEAWLNNKRT SNPTGNYSAD
CMIDHIHLVD CEEELYHTDS CMSNRTEKYR CPSNKVCIEW DQLCDMSLDC YGGEDEDATL
HNCSQVPMGA RCTFENGTCG WTSDAISEFR WVIANASSKI HIDKESRIAQ NVVDHTLRNS
SGHFLFVEPG SSEKMLRAHY TSPLFPAMSK SLQDPESPYY QQCRIRFFYH HFSRDWHSVF
LFLVSPDGRE RRKIWEEDKL MPSLVDYHDF FWHRVSTIIP FQDNDYKLQF VAIRMAIFHG
NFGLDDISMT PQCFLQGFNE ASLAPVYNFS TCGAAGSWGP NQTMCDSAYN NTPVEVKVLD
NWNKQGVQSW KVPFTGEYRV VAGGAAGGLV FDRTDSPTMS NKGALVESTF NFTKNEQLWI
AIGQQGQNPC ASVGAGSVLM KTLKAGTAEI CGETDLTKLR EKYNLIELPG TGGGGATFLA
KMNITGQKMG SLLLVAAGGG GQYFGGGDFM DSAGRDAAET NVSNSGSSMS HGLKVISGGG
GGADHASPRT HLLHMPEGRT FAAGARGGVC SSFEFWKAAG GFGGGGASCG PGGGGGGGFV
GGDGGNYSHG QGGRSMSFTK TAVFFSDRNP GSGFISIYPC LKVCPDASMC RFMGRMQVCI
CYDGQLLNTS DAVCQIKLSQ ASDLFSTLSG LSNQDKILIM VIFAFTFLAA TCFVISFIAI
RHKCLSRFGA KTDKKGYTRP GMPMEQFIGQ NFHSEYNPNY EFFNNGDTAY NLQDLKEIPR
CCVLLIKALG QGAFGEVYEG TLVGLCSEKD GLPVAVKTLP EYASEQAQMD FHMEAMIMSK
FRHPNIVQFH GVCFEKMPRF IVLELLAGGD LKTFLRENRP KEGKPTELEI FDLLQIALDV
AKGCKYLEEN HFIHRDIAAR NCLLTTKSKS RVVKIADFGM ARDIYRADYY RKGGKAMLPV
KWMPPEAFLD GIFTSKTDVW SYGVLLWEIF SMGYMPYPGR GNQEVMQLVT AGGRLECPSS
CPLKLYQIMT HCWNTVSESR PNFDAIISRL EACMHDPLIL THPLPKVLKP CLTVDTNTCD
SIPTSAVNNN NNMNNSCLFS NNNNNSEAIF SNLSGIKVDL YPPYQRKKTS FDVPGQDSIP
LADGDVFTTN TGETAVVRLS VQTSAKVSGC NEACCLADRL VCRWLAV
//
