ID A0A0V1PNC7_9BILA Unreviewed; 1397 AA.
AC A0A0V1PNC7;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 22-FEB-2023, entry version 24.
DE RecName: Full=Vinculin {ECO:0000256|ARBA:ARBA00014125};
GN ORFNames=T08_742 {ECO:0000313|EMBL:KRZ97673.1};
OS Trichinella sp. T8.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=92180 {ECO:0000313|EMBL:KRZ97673.1, ECO:0000313|Proteomes:UP000054924};
RN [1] {ECO:0000313|EMBL:KRZ97673.1, ECO:0000313|Proteomes:UP000054924}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS272 {ECO:0000313|EMBL:KRZ97673.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell junction, adherens junction
CC {ECO:0000256|ARBA:ARBA00004536}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004413}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004413}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004413}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the vinculin/alpha-catenin family.
CC {ECO:0000256|ARBA:ARBA00008376}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ97673.1}.
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DR EMBL; JYDM01000002; KRZ97673.1; -; Genomic_DNA.
DR Proteomes; UP000054924; Unassembled WGS sequence.
DR GO; GO:0015629; C:actin cytoskeleton; IEA:InterPro.
DR GO; GO:0005912; C:adherens junction; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR Gene3D; 1.20.120.230; Alpha-catenin/vinculin-like; 5.
DR Gene3D; 1.20.120.810; Vinculin, Vh2 four-helix bundle; 2.
DR InterPro; IPR036723; Alpha-catenin/vinculin-like_sf.
DR InterPro; IPR017997; Vinculin.
DR InterPro; IPR006077; Vinculin/catenin.
DR InterPro; IPR000633; Vinculin_CS.
DR PANTHER; PTHR46180; VINCULIN; 1.
DR PANTHER; PTHR46180:SF1; VINCULIN; 1.
DR Pfam; PF01044; Vinculin; 2.
DR PRINTS; PR00806; VINCULIN.
DR SUPFAM; SSF47220; alpha-catenin/vinculin-like; 6.
DR PROSITE; PS00664; VINCULIN_2; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000054924};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REGION 602..626
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1143..1200
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 527..554
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 610..626
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1171..1190
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1397 AA; 155899 MW; 05B6BC4B59E6B467 CRC64;
MPVFHTKTIE SILEPVAQQL ILLVGFVSNG STTAGRAFRH VFFGIQTCRK LADAHVDMYN
MQKSTLQQQS SNNRNGIRST LINRKQYPLR QRKYELVILV INLSDRVSRL VILHEEAEDG
NAMPDLTRPV DAVSRAVENL VQVGYDTIHL SDDDILKQDM PPALQRVETS SRLLEEACYV
LRDDPYSSQG RKKLIEGSRG ILQGTSALLL CFDESEVRKI VRGCKKVLDY LAVAEVIENM
EDLVQFVRDI SPWLTKMSRD TEAREKELTH HVHREILIRC IDSVKTLAPI LICAMKIFIQ
ISAQGGSKGV PEAAENRNYL SSRMIEEVNE VIRVLQLTTY DEDEWNEDDL IVMKKALSAI
ESLLQAALDW LADPRALRGG VGEKSLRRIL VYAERIADRA LPEDASLIRR ACSDIASMTD
SLCELRHNKQ GDSPQCQGLA RGIAQKLREL VGGKDIAGLL PHALQGLEQA GIAQPAHTVL
GRMDQVLKWL DAPYMDDRGV GLNALKALLA EGRKVADLCS PREKYAMNEL CDEIERLSHQ
LAELQRKGMG YEKRRRVSSS DRAEWAFARP LARRPAPDTF IQPSQSRRWS IKSAGESLSA
GRPYSSVGAA KKRTTPTCQA GSLPRSSTMP LASEPFQSLN LLLQRLVTEL WRNKRTCAFQ
TPTTTAKSTA PARPSTTVPH FHVCKAFLYN PYRGAAAGPA ESSSSSPPRR VFFETESLLA
PLVVRIGDSP QARAIANQLK DKLGELKRMM DRALLDRVVD DFSDITTPLK QFAEAVLAPE
GTPARDANFA EKAQNLRDHC QRCAKTGRLV GTSGPCKDKK IVEALCSTAN QISNMTPQVI
NAGKIRFHYP QNVSADEHFE NLRRELSDAL QRLRSLVDDA VDPLEFVKAS ENAIRRHGQE
CENAISNDEP QKMADHASSI ARLANRVLMA AKGQAENSED PAFSGRMNDA ASRLQGTIPP
MVNDAKQVAL NPRDQSAAGR WRDSNKKLVD AVGSVRRALE PSQLPEMKNL DINGRVAVLV
GLCCAGMTVG TKGGARSSSR VCKVSSPLSV DVGYESDTAA PVSWSRPMRS KDVVDFDYPN
IDFHSMFDMW LYQMPPVNLS SLYDLRRLPT LFHRRSASPR RRRRNRHRRC LTLSFPVDWE
REQRTGRRRE VRAPPPPPAW YQAASHREGP ASPNRPPPQL MEMRTPPRPP PPQETDDEEE
MRAFWERVPL PKANQPILSA AHSLHREVQQ WSSRENEIVA AAKRMAILMA RLSQLVRGEG
GTKKDLIDCA KAIADASEEV TRLAVLLARQ CTDIKMRKAL LQVCERIPTI ATQLKILSTV
KATMLGSQAP MSVREGSEIS PGTDEDEEAM QQLVLNAQNL MQSVKDTVRA AEAASIKIRT
DSGLRLRWVR KPVWANY
//
