ID A0A0V1PNI0_9BILA Unreviewed; 901 AA.
AC A0A0V1PNI0;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Glutamate receptor 1 {ECO:0000313|EMBL:KRZ97745.1};
GN Name=glr-1 {ECO:0000313|EMBL:KRZ97745.1};
GN ORFNames=T08_8631 {ECO:0000313|EMBL:KRZ97745.1};
OS Trichinella sp. T8.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=92180 {ECO:0000313|EMBL:KRZ97745.1, ECO:0000313|Proteomes:UP000054924};
RN [1] {ECO:0000313|EMBL:KRZ97745.1, ECO:0000313|Proteomes:UP000054924}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS272 {ECO:0000313|EMBL:KRZ97745.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC family. {ECO:0000256|ARBA:ARBA00008685}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ97745.1}.
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DR EMBL; JYDM01000002; KRZ97745.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V1PNI0; -.
DR STRING; 92180.A0A0V1PNI0; -.
DR Proteomes; UP000054924; Unassembled WGS sequence.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-KW.
DR GO; GO:0015276; F:ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR CDD; cd06380; PBP1_iGluR_AMPA; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 2.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR019594; Glu/Gly-bd.
DR InterPro; IPR001508; Iono_Glu_rcpt_met.
DR InterPro; IPR015683; Ionotropic_Glu_rcpt.
DR InterPro; IPR001320; Iontro_rcpt_C.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR18966:SF544; GLUTAMATE RECEPTOR 1; 1.
DR PANTHER; PTHR18966; IONOTROPIC GLUTAMATE RECEPTOR; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00060; Lig_chan; 1.
DR Pfam; PF10613; Lig_chan-Glu_bd; 1.
DR PRINTS; PR00177; NMDARECEPTOR.
DR SMART; SM00918; Lig_chan-Glu_bd; 1.
DR SMART; SM00079; PBPe; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00023257};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:KRZ97745.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000054924};
KW Signal {ECO:0000256|SAM:SignalP}; Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..901
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5006884390"
FT TRANSMEM 578..597
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 653..675
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 841..865
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 447..818
FT /note="Ionotropic glutamate receptor C-terminal"
FT /evidence="ECO:0000259|SMART:SM00079"
FT DOMAIN 457..522
FT /note="Ionotropic glutamate receptor L-glutamate and
FT glycine-binding"
FT /evidence="ECO:0000259|SMART:SM00918"
SQ SEQUENCE 901 AA; 103236 MW; BC9D6D9C9E5A553C CRC64;
MFHVKWILFL LFNHANGNLR VPVGALFRDE MEDGLISVMT YATMENNYQQ NPPPFRLETK
KGIIRTDSVN NWALTRLGCE VIKDGAFVLM GTANYPSREA FVALSNLLHL PLINWSTAKR
ESQNGQFEIN MAQNTAEAVG DFIRLKMWKN FTYMYDSIDG LYEYELLNNY LKKTGTEVRT
QMLYLKNIEP DYFRFFLNFH SSRFASDSYV ILHISNRKKL KFILRDLLDA AMKTKNFHYL
ISGQEVLDAE IEKFKIGLIN VSGFQYEGRD KSSFKDFLEK WSRLDSQLLH YHKASTITAE
EALVYDAIQI VIEAFKSIAK VNASALKRYY KKDEFINEDY HGLLCYTFED KMNPDRPFLP
LRHGEMMYDA LKKTRLDGIS GNVQFDDDGN RVNYTLKLTE VLQTGHNAGV VNVQKRLWRQ
KAGFQNGEDH PQKGEKINKN IQPFNRTRII TTIINEPFVM FKKDADQFTG NDRFEGFCVD
LMKLLSEKIE NFPYIIKPVK DNQYGAVDQN GRWNGMVGEL IRGEADLAIA SLTINTLRER
VVDFSKPFLT TGISIMIKKP DKQEFSIFSF MQPLSTEVWI FIIIAYGGVS IVIFFIARFS
PYEWNYNQSS TYGCTSLSDF TIDNCLWVTL AALMQQGTDI MPRSASCRIA SSIWWFFTMI
IVSSYTANLA AFLTLEKMHA PIESVEDLAR QTKIKYGIQA SGSTAQFFKE SKVDVHRRMW
QYMSTQVPSP LVSSYAEGIQ RVRESKGQYA FLLEATTNEY ASTRKPCDTI KVGANLNSIG
YGVATPFGSD LSEKINLAIL ELQEIGELKR LEMKWWYEKG QCEQGMSDSQ SASLTLSKVA
GIFYILTVGI IIAMLVSFVE IFYYLNAEKH SKIPSEPFCI QSAVENYGKA EMLTNSKEIT
T
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