ID A0A0V1PNX5_9BILA Unreviewed; 411 AA.
AC A0A0V1PNX5;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=3-hydroxyisobutyryl-CoA hydrolase, mitochondrial {ECO:0000256|ARBA:ARBA00016714};
DE EC=3.1.2.4 {ECO:0000256|ARBA:ARBA00011915};
DE AltName: Full=3-hydroxyisobutyryl-coenzyme A hydrolase {ECO:0000256|ARBA:ARBA00031181};
DE Flags: Fragment;
GN Name=HIBCH {ECO:0000313|EMBL:KRZ97890.1};
GN ORFNames=T08_13000 {ECO:0000313|EMBL:KRZ97890.1};
OS Trichinella sp. T8.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC Trichinellida; Trichinellidae; Trichinella.
OX NCBI_TaxID=92180 {ECO:0000313|EMBL:KRZ97890.1, ECO:0000313|Proteomes:UP000054924};
RN [1] {ECO:0000313|EMBL:KRZ97890.1, ECO:0000313|Proteomes:UP000054924}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ISS272 {ECO:0000313|EMBL:KRZ97890.1};
RA Korhonen P.K., Edoardo P., Giuseppe L.R., Gasser R.B.;
RT "Evolution of Trichinella species and genotypes.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline
CC catabolite. Has high activity toward isobutyryl-CoA. Could be an
CC isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also
CC hydrolyzes 3-hydroxypropanoyl-CoA. {ECO:0000256|ARBA:ARBA00024871}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-
CC methylpropanoate + CoA + H(+); Xref=Rhea:RHEA:20888,
CC ChEBI:CHEBI:11805, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57340; EC=3.1.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00001709};
CC -!- SIMILARITY: Belongs to the enoyl-CoA hydratase/isomerase family.
CC {ECO:0000256|ARBA:ARBA00005254}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KRZ97890.1}.
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DR EMBL; JYDM01000001; KRZ97890.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0V1PNX5; -.
DR STRING; 92180.A0A0V1PNX5; -.
DR UniPathway; UPA00362; -.
DR Proteomes; UP000054924; Unassembled WGS sequence.
DR GO; GO:0003860; F:3-hydroxyisobutyryl-CoA hydrolase activity; IEA:UniProtKB-EC.
DR GO; GO:0006574; P:valine catabolic process; IEA:UniProtKB-UniPathway.
DR CDD; cd06558; crotonase-like; 1.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR045004; ECH_dom.
DR InterPro; IPR032259; HIBYL-CoA-H.
DR PANTHER; PTHR43176:SF3; 3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43176; 3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED; 1.
DR Pfam; PF16113; ECH_2; 1.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:KRZ97890.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000054924}.
FT DOMAIN 47..399
FT /note="Enoyl-CoA hydratase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF16113"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KRZ97890.1"
SQ SEQUENCE 411 AA; 46468 MW; 6C766C5542355B7F CRC64;
LMSTMAAFLN KHFTCANKLS ISWISATRSL CQSASEVLFH ESNGKLLVTL NRPTALNALN
INMAKMMFEK LKKTNTDNSI KMVILKGAGN KAFCAGGDIR GFHLIFLLTA LALSIKNNDG
LVEEFFREEY KLNYLIGKFR VPFVSLIDGI VMGGGVGLSV HGTFRVATER TVFAMPETAI
GLFPDVGGSF FLPRLKNKLG FYLGLTGARL SGEDVFEAGI ATHYVHSKWM PELQSELINA
KEINSRSIKT ILDSYHRKSI TSDREFCLNF CLPKIEKLFS VATVEELFHK LKEDGSQWAT
ECLETMKKMV FFLNCILSVT DCLFQSPTSL KITLRQLKAG MWLEFRECFQ MEYRISQRCV
KEHDLTEGIR AALLDKDKTP KWIPGTLEEV TEEDIDKYFK VLPAERELYL P
//
