ID A0A0V7ZVN6_9CYAN Unreviewed; 575 AA.
AC A0A0V7ZVN6;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=Rqc2 homolog RqcH {ECO:0000256|HAMAP-Rule:MF_00844};
DE Short=RqcH {ECO:0000256|HAMAP-Rule:MF_00844};
GN Name=rqcH {ECO:0000256|HAMAP-Rule:MF_00844};
GN ORFNames=BC008_31755 {ECO:0000313|EMBL:KST67968.1}, BC008_33370
GN {ECO:0000313|EMBL:KST68407.1};
OS Mastigocoleus testarum BC008.
OC Bacteria; Cyanobacteriota; Cyanophyceae; Nostocales; Hapalosiphonaceae;
OC Mastigocoleus.
OX NCBI_TaxID=371196 {ECO:0000313|EMBL:KST68407.1, ECO:0000313|Proteomes:UP000053372};
RN [1] {ECO:0000313|EMBL:KST68407.1, ECO:0000313|Proteomes:UP000053372}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BC008 {ECO:0000313|EMBL:KST68407.1,
RC ECO:0000313|Proteomes:UP000053372};
RA Guida B.S., Garcia-Pichel F.;
RT "Draft Genome of the Euendolithic (true boring) Cyanobacterium
RT Mastigocoleus testarum strain BC008.";
RL Genome Announc. 0:0-0(2015).
CC -!- FUNCTION: Part of the ribosome quality control system (RQC). Recruits
CC Ala-charged tRNA and directs the elongation of stalled nascent chains
CC on 50S ribosomal subunits, leading to non-templated C-terminal Ala
CC extensions (Ala tail). The Ala tail promotes nascent chain degradation.
CC May add between 1 and at least 8 Ala residues. Binds to stalled 50S
CC ribosomal subunits. {ECO:0000256|HAMAP-Rule:MF_00844}.
CC -!- SUBUNIT: Associates with stalled 50S ribosomal subunits.
CC {ECO:0000256|HAMAP-Rule:MF_00844}.
CC -!- SIMILARITY: Belongs to the NEMF family. {ECO:0000256|HAMAP-
CC Rule:MF_00844}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KST68407.1}.
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DR EMBL; LMTZ01000083; KST67968.1; -; Genomic_DNA.
DR EMBL; LMTZ01000066; KST68407.1; -; Genomic_DNA.
DR RefSeq; WP_027843065.1; NZ_LMTZ01000083.1.
DR AlphaFoldDB; A0A0V7ZVN6; -.
DR OrthoDB; 9766163at2; -.
DR Proteomes; UP000053372; Unassembled WGS sequence.
DR GO; GO:0043023; F:ribosomal large subunit binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0072344; P:rescue of stalled ribosome; IEA:UniProtKB-UniRule.
DR Gene3D; 2.30.310.10; ibrinogen binding protein from staphylococcus aureus domain; 1.
DR HAMAP; MF_00844_B; RqcH_B; 1.
DR InterPro; IPR008532; NFACT_RNA-bd.
DR InterPro; IPR043682; RqcH_bacterial.
DR PANTHER; PTHR15239; NUCLEAR EXPORT MEDIATOR FACTOR NEMF; 1.
DR PANTHER; PTHR15239:SF6; RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT NEMF; 1.
DR Pfam; PF05670; NFACT-R_1; 1.
DR Pfam; PF05833; NFACT_N; 1.
PE 3: Inferred from homology;
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917, ECO:0000256|HAMAP-
KW Rule:MF_00844}; Reference proteome {ECO:0000313|Proteomes:UP000053372};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|HAMAP-
KW Rule:MF_00844};
KW tRNA-binding {ECO:0000256|ARBA:ARBA00022555, ECO:0000256|HAMAP-
KW Rule:MF_00844}.
FT DOMAIN 457..550
FT /note="NFACT RNA-binding"
FT /evidence="ECO:0000259|Pfam:PF05670"
SQ SEQUENCE 575 AA; 66551 MW; AE7ED414EF13E97E CRC64;
MQTFDYTTLK AVCSDIRDRW LPSRLEQVHQ RDKYTIAIAL RTLKGRSWLD ISRHPQAARI
CIGEPPPRKP DTFTFSQQLV HQLGGLALIE IETIAPWERA IDLRFARRPD ESPLYHLYVE
IMGKYSNMVL TDANNQIITV AHQISQQKSS VRSVLTGQLY EAPPALTNSI PSLSEPFERW
WERVSLVPGS IKRQLLKTYR GISPSLLESM LQVSEINPQT HTDKLTSQEW QKLFQTWRVW
LQSLEQESFN PALTKTGYTV LGWGGVEPVQ DIQVLIDKYY TEKLNQQAFS QLQHQLNQKI
NNFLTKLRVK AQNFEERLQQ SDRADEYRQK ADLLMAHLHE WKPGIQKMVL PNFENGEPVK
IKLEPDKNAV QNAQGLYKKH QKLKRARFAV EPLLLEVKDE INYLEQVEAS ISQINNYQST
EDLQALEEIR EELVGQKYLE DTEYRRRSST QTASTNFHQY HTPGGFEVLI GRNNRQNDQL
SFKIAGDYDL WFHAQEIPGS HVLLRLEAGT TPKSEDLQFV ANLAAYHSRS RQSKQVPVVY
TQPKYVYKPK GAKPGIAIYK QEQVIWGKPY LVEGD
//
