ID A0A0V8QGK9_9FIRM Unreviewed; 793 AA.
AC A0A0V8QGK9;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=Endonuclease MutS2 {ECO:0000256|HAMAP-Rule:MF_00092};
DE EC=3.1.-.- {ECO:0000256|HAMAP-Rule:MF_00092};
GN Name=mutS2 {ECO:0000256|HAMAP-Rule:MF_00092};
GN ORFNames=ASU35_01400 {ECO:0000313|EMBL:KSV59684.1};
OS Acetivibrio ethanolgignens.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Oscillospiraceae;
OC Acetivibrio.
OX NCBI_TaxID=290052 {ECO:0000313|EMBL:KSV59684.1, ECO:0000313|Proteomes:UP000054874};
RN [1] {ECO:0000313|EMBL:KSV59684.1, ECO:0000313|Proteomes:UP000054874}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ACET-33324 {ECO:0000313|EMBL:KSV59684.1,
RC ECO:0000313|Proteomes:UP000054874};
RA Zou Y., Xue W., Luo G., Lv M.;
RT "Butyribacter intestini gen. nov., sp. nov., a butyric acid-producing
RT bacterium of the family Lachnospiraceae isolated from the human faeces.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Endonuclease that is involved in the suppression of
CC homologous recombination and may therefore have a key role in the
CC control of bacterial genetic diversity. {ECO:0000256|HAMAP-
CC Rule:MF_00092}.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|HAMAP-Rule:MF_00092}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family. MutS2
CC subfamily. {ECO:0000256|HAMAP-Rule:MF_00092}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KSV59684.1}.
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DR EMBL; LNAM01000112; KSV59684.1; -; Genomic_DNA.
DR RefSeq; WP_058352214.1; NZ_LNAM01000112.1.
DR AlphaFoldDB; A0A0V8QGK9; -.
DR STRING; 290052.ASU35_01400; -.
DR OrthoDB; 9808166at2; -.
DR Proteomes; UP000054874; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR GO; GO:0045910; P:negative regulation of DNA recombination; IEA:InterPro.
DR CDD; cd03280; ABC_MutS2; 1.
DR Gene3D; 3.30.1370.110; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00092; MutS2; 1.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR046893; MSSS.
DR InterPro; IPR005747; MutS2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR002625; Smr_dom.
DR InterPro; IPR036063; Smr_dom_sf.
DR NCBIfam; TIGR01069; mutS2; 1.
DR PANTHER; PTHR48378; DNA MISMATCH REPAIR PROTEINS MUTS FAMILY DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR PANTHER; PTHR48378:SF2; SMR DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF20297; MSSS; 1.
DR Pfam; PF00488; MutS_V; 1.
DR Pfam; PF01713; Smr; 1.
DR PIRSF; PIRSF005814; MutS_YshD; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SMART; SM00463; SMR; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF160443; SMR domain-like; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
DR PROSITE; PS50828; SMR; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00092}; Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00092};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759, ECO:0000256|HAMAP-
KW Rule:MF_00092}; Hydrolase {ECO:0000256|HAMAP-Rule:MF_00092};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722, ECO:0000256|HAMAP-Rule:MF_00092};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00092}; Reference proteome {ECO:0000313|Proteomes:UP000054874}.
FT DOMAIN 718..793
FT /note="Smr"
FT /evidence="ECO:0000259|PROSITE:PS50828"
FT COILED 235..266
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 527..625
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 336..343
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00092"
SQ SEQUENCE 793 AA; 88876 MW; 3AE0D7889594577B CRC64;
MNEKALKTLE YNKIIDKLVA FAGSELGRER CKKLLPMTDI GEIRRNQQET SDALTRVLRK
GSLSFSGLRD IRASIMRLEV GGVLGMGELL QVSSVLNVAL RVKSYGRSEG SEEETAIDSL
RERFSLLEPL SPLNNEIKRC ILSEEEMSDD ASPTLRHIRR SIKLTNDRVR EQLNTIVNAS
SNQTMLQENI VTMRNGRYCL PIKAEYKSQF NGMVHDQSSS GSTLFIEPMA VVKLNNELRE
LAVKENDEIE RILAELSNQA GEYCQELKDD ITILAELDFI FAKASLSKGM RASEPVFNDK
GYINIKKGRH PLIDNKKVVP IDIHMGKDFN LLIVTGPNTG GKTVSLKTVG LFTLMGQAGL
HIPAFDGSEL GVFEEVYADI GDEQSIEQSL STFSSHMVNT VSIIKEANYR SLVLFDELGA
GTDPTEGAAL AMSILSYLHK KQIRTMATTH YSELKIFALS TEGVENACCE FDVETLRPTY
RLLIGIPGKS NAFAISSKLG LPDYIITDAK ERIGEKEQSF EDVISDLEKS RVTMEKDQEE
IARYKEEVER LKKKLEQKNE RIDEAKEKIL RRANEEAREI IQEAKDFADE SIRKYNKWMK
DGSMNREMEK QRSELRDKLN STESKLALKG QKAKKQHKAS DFKIGDAVRV LSMNLNGTVS
SLPNDKGDLF VQMGILRSQV NIKDLELIDE PVITGPNMKK TGSGQIKMAK TAYISPELNL
IGKLVDEALP ILDKYLDDAY LAHLPQVTII HGRGTGALRN AVHNHLKKTR YVKSYRVGGF
GEGDHGVTIV EFK
//
