ID A0A0V8RX03_PYROC Unreviewed; 455 AA.
AC A0A0V8RX03;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Phosphomethylpyrimidine kinase {ECO:0000313|EMBL:KSW12564.1};
DE EC=2.7.4.7 {ECO:0000313|EMBL:KSW12564.1};
GN ORFNames=CF15_07570 {ECO:0000313|EMBL:KSW12564.1};
OS Pyrodictium occultum.
OC Archaea; Thermoproteota; Thermoprotei; Desulfurococcales; Pyrodictiaceae;
OC Pyrodictium.
OX NCBI_TaxID=2309 {ECO:0000313|EMBL:KSW12564.1, ECO:0000313|Proteomes:UP000053352};
RN [1] {ECO:0000313|EMBL:KSW12564.1, ECO:0000313|Proteomes:UP000053352}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PL-19 {ECO:0000313|EMBL:KSW12564.1,
RC ECO:0000313|Proteomes:UP000053352};
RA Utturkar S., Huber H., Leptihn S., Brown S., Stetter K.O., Podar M.;
RT "Genome sequence of Pyrodictium occultum PL-19, a marine hyperthermophilic
RT archaeon isolated from Volcano, Italy.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KSW12564.1}.
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DR EMBL; LNTB01000001; KSW12564.1; -; Genomic_DNA.
DR RefSeq; WP_058371246.1; NZ_LNTB01000001.1.
DR AlphaFoldDB; A0A0V8RX03; -.
DR STRING; 2309.CF15_07570; -.
DR OrthoDB; 43786at2157; -.
DR Proteomes; UP000053352; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0008972; F:phosphomethylpyrimidine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0004789; F:thiamine-phosphate diphosphorylase activity; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0009228; P:thiamine biosynthetic process; IEA:InterPro.
DR CDD; cd01169; HMPP_kinase; 1.
DR Gene3D; 3.40.1190.20; -; 1.
DR Gene3D; 3.40.225.10; Class II aldolase/adducin N-terminal domain; 1.
DR InterPro; IPR036409; Aldolase_II/adducin_N_sf.
DR InterPro; IPR011761; ATP-grasp.
DR InterPro; IPR004399; HMP/HMP-P_kinase_dom.
DR InterPro; IPR013749; PM/HMP-P_kinase-1.
DR InterPro; IPR029056; Ribokinase-like.
DR InterPro; IPR019293; ThiN.
DR NCBIfam; TIGR00097; HMP-P_kinase; 1.
DR PANTHER; PTHR20858:SF17; HYDROXYMETHYLPYRIMIDINE_PHOSPHOMETHYLPYRIMIDINE KINASE THI20-RELATED; 1.
DR PANTHER; PTHR20858; PHOSPHOMETHYLPYRIMIDINE KINASE; 1.
DR Pfam; PF08543; Phos_pyr_kin; 1.
DR Pfam; PF10120; ThiP_synth; 1.
DR SUPFAM; SSF53639; AraD/HMP-PK domain-like; 1.
DR SUPFAM; SSF53613; Ribokinase-like; 1.
DR PROSITE; PS50975; ATP_GRASP; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00409};
KW Kinase {ECO:0000313|EMBL:KSW12564.1};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00409};
KW Reference proteome {ECO:0000313|Proteomes:UP000053352};
KW Transferase {ECO:0000313|EMBL:KSW12564.1}.
FT DOMAIN 68..120
FT /note="ATP-grasp"
FT /evidence="ECO:0000259|PROSITE:PS50975"
SQ SEQUENCE 455 AA; 48526 MW; DED1509E55B083B2 CRC64;
MERRIRPVAL TIAGSDSGGG AGVEADLKTF AALGVHGAAA VTAVTAQNTL GVQAVHLIPP
GLVAAQIRAV AEDMGVDAAK TGMLGSAETI LEVARVLESY DFPLVVDPVT AAESDGTRLM
PDRALEALRE KLLPRAALVT PNALEAEMLT GIRITSIEEA RRAAKLLVEE YGAEAALVKG
GHLGGRESID VLYHRGGFHE YRAPRLSHGC SHGTGCTLSA AITAELAKGR PLEEAVRTAK
SLVTAAIEYA ARLGRGACPV NPVAALEMDA WRWRVARSVE RASSMILQAE SLVAPHVPEV
GTNVVEALPA PYARSREDVA GILGRIVRTP RGLRAGPVAF GASDHLARLV LEVMKYTPWI
RSVINIRYSP ELVEAARKLG YRVARIDRAA EPPETRTAEG GTMKWIARSV FPHSPADLVY
DEGDWGKEPM IRIFAGTAVE AARKLLKILE RASHS
//
