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Database: UniProt
Entry: A0A0V9JYJ1_9ENTR
LinkDB: A0A0V9JYJ1_9ENTR
Original site: A0A0V9JYJ1_9ENTR 
ID   A0A0V9JYJ1_9ENTR        Unreviewed;       558 AA.
AC   A0A0V9JYJ1;
DT   16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT   16-MAR-2016, sequence version 1.
DT   08-MAY-2019, entry version 24.
DE   RecName: Full=Oxygen-dependent choline dehydrogenase {ECO:0000256|HAMAP-Rule:MF_00750};
DE            Short=CDH {ECO:0000256|HAMAP-Rule:MF_00750};
DE            Short=CHD {ECO:0000256|HAMAP-Rule:MF_00750};
DE            EC=1.1.99.1 {ECO:0000256|HAMAP-Rule:MF_00750};
DE   AltName: Full=Betaine aldehyde dehydrogenase {ECO:0000256|HAMAP-Rule:MF_00750};
DE            Short=BADH {ECO:0000256|HAMAP-Rule:MF_00750};
DE            EC=1.2.1.8 {ECO:0000256|HAMAP-Rule:MF_00750};
GN   Name=betA {ECO:0000256|HAMAP-Rule:MF_00750};
GN   ORFNames=APU02_00900 {ECO:0000313|EMBL:KSY33520.1};
OS   Citrobacter sp. 50677481.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Citrobacter.
OX   NCBI_TaxID=1736699 {ECO:0000313|EMBL:KSY33520.1, ECO:0000313|Proteomes:UP000053666};
RN   [1] {ECO:0000313|Proteomes:UP000053666}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=50677481 {ECO:0000313|Proteomes:UP000053666};
RA   Samuelsen O.;
RL   Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in the biosynthesis of the osmoprotectant
CC       glycine betaine. Catalyzes the oxidation of choline to betaine
CC       aldehyde and betaine aldehyde to glycine betaine at the same rate.
CC       {ECO:0000256|HAMAP-Rule:MF_00750, ECO:0000256|SAAS:SAAS00321133}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=A + choline = AH2 + betaine aldehyde;
CC         Xref=Rhea:RHEA:17433, ChEBI:CHEBI:13193, ChEBI:CHEBI:15354,
CC         ChEBI:CHEBI:15710, ChEBI:CHEBI:17499; EC=1.1.99.1;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_00750,
CC         ECO:0000256|RuleBase:RU003969, ECO:0000256|SAAS:SAAS01117340};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=betaine aldehyde + H2O + NAD(+) = betaine + 2 H(+) +
CC         NADH; Xref=Rhea:RHEA:15305, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:15710, ChEBI:CHEBI:17750,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.2.1.8;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_00750,
CC         ECO:0000256|SAAS:SAAS01117337};
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000256|HAMAP-
CC         Rule:MF_00750, ECO:0000256|SAAS:SAAS01080756};
CC   -!- PATHWAY: Amine and polyamine biosynthesis; betaine biosynthesis
CC       via choline pathway; betaine aldehyde from choline (cytochrome c
CC       reductase route): step 1/1. {ECO:0000256|HAMAP-Rule:MF_00750,
CC       ECO:0000256|RuleBase:RU003969, ECO:0000256|SAAS:SAAS00321105}.
CC   -!- SIMILARITY: Belongs to the GMC oxidoreductase family.
CC       {ECO:0000256|HAMAP-Rule:MF_00750, ECO:0000256|RuleBase:RU003968,
CC       ECO:0000256|SAAS:SAAS01080758}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KSY33520.1}.
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DR   EMBL; LNHZ01000001; KSY33520.1; -; Genomic_DNA.
DR   RefSeq; WP_060568943.1; NZ_LNHZ01000001.1.
DR   EnsemblBacteria; KSY33520; KSY33520; APU02_00900.
DR   UniPathway; UPA00529; UER00385.
DR   Proteomes; UP000053666; Unassembled WGS sequence.
DR   GO; GO:0008802; F:betaine-aldehyde dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008812; F:choline dehydrogenase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR   GO; GO:0019285; P:glycine betaine biosynthetic process from choline; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.50.50.60; -; 1.
DR   Gene3D; 4.10.450.10; -; 1.
DR   HAMAP; MF_00750; Choline_dehydrogen; 1.
DR   InterPro; IPR011533; BetA.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR027424; Glucose_Oxidase_domain_2.
DR   InterPro; IPR012132; GMC_OxRdtase.
DR   InterPro; IPR000172; GMC_OxRdtase_N.
DR   InterPro; IPR007867; GMC_OxRtase_C.
DR   PANTHER; PTHR11552:SF157; PTHR11552:SF157; 1.
DR   Pfam; PF05199; GMC_oxred_C; 1.
DR   Pfam; PF00732; GMC_oxred_N; 1.
DR   PIRSF; PIRSF000137; Alcohol_oxidase; 1.
DR   SUPFAM; SSF51905; SSF51905; 1.
DR   TIGRFAMs; TIGR01810; betA; 1.
DR   PROSITE; PS00623; GMC_OXRED_1; 1.
DR   PROSITE; PS00624; GMC_OXRED_2; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000053666};
KW   FAD {ECO:0000256|HAMAP-Rule:MF_00750, ECO:0000256|RuleBase:RU003968,
KW   ECO:0000256|SAAS:SAAS01080750};
KW   Flavoprotein {ECO:0000256|HAMAP-Rule:MF_00750,
KW   ECO:0000256|RuleBase:RU003968, ECO:0000256|SAAS:SAAS01080744};
KW   NAD {ECO:0000256|HAMAP-Rule:MF_00750, ECO:0000256|SAAS:SAAS00321145};
KW   Oxidoreductase {ECO:0000256|HAMAP-Rule:MF_00750,
KW   ECO:0000256|SAAS:SAAS01080751, ECO:0000313|EMBL:KSY33520.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053666}.
FT   DOMAIN       82    105       GMC_OxRdtase_N. {ECO:0000259|PROSITE:
FT                                PS00623}.
FT   DOMAIN      259    273       GMC_OxRdtase_N. {ECO:0000259|PROSITE:
FT                                PS00624}.
FT   NP_BIND       4     33       FAD. {ECO:0000256|HAMAP-Rule:MF_00750}.
FT   ACT_SITE    473    473       Proton acceptor. {ECO:0000256|HAMAP-Rule:
FT                                MF_00750}.
SQ   SEQUENCE   558 AA;  61596 MW;  7DF8D45694EC5A86 CRC64;
     MHFDYIIIGA GSAGNVLATR LTEDSNTTVL LLEAGGPDYR ADFRTQMPAA LAYPLQGKRY
     NWAYETEPEP HMNYRRMECG RGKGLGGSSL INGMCYVRGN AMDLDNWANE PGLEHWSYLH
     CLPYYRKAES RDIGANDYHG GDGPVCVTTS KPHVNPLFDA MIEAGVQAGY PRTDDLNGYQ
     QEGFGPMDRT VTPQGRRAST ARGYLDQARK RPNLTIITHA LTDHIIFDGK KAVGVEWLEG
     DGTIPTTATA EKEVLLCAGA IASPQILQRS GVGDAALLKA FAIPLVHHLP GVGENLQDHL
     EMYLQYACKK PVSLYPALQW WNQPKIGAEW LFGGTGIGAS NHFEAGGFIR SRDAFTWPNI
     QYHFLPVAIN YNGSNAVKEH GFQCHVGSMR SPSRGHVHLK SRDPREHPAI LFNYMSTDQD
     WQEFRDAIRI TREIINQPAL DPFRGREISP GSDCQSDEQL DAFVREHAET AFHPCGTCKM
     GFDEMAVVDG EGRVHGVENL RVVDASIMPQ IITGNLNATT IMIGEKLADA IRGRAPLAKS
     TASYYVAGDT PVRQAPRR
//
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