ID A0A0W0G1Y1_9AGAR Unreviewed; 1090 AA.
AC A0A0W0G1Y1;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE RecName: Full=Transcription elongation factor SPT5 {ECO:0000256|ARBA:ARBA00020181, ECO:0000256|PIRNR:PIRNR036945};
GN ORFNames=WG66_4858 {ECO:0000313|EMBL:KTB42573.1};
OS Moniliophthora roreri.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Marasmiineae; Marasmiaceae; Moniliophthora.
OX NCBI_TaxID=221103 {ECO:0000313|EMBL:KTB42573.1, ECO:0000313|Proteomes:UP000054988};
RN [1] {ECO:0000313|EMBL:KTB42573.1, ECO:0000313|Proteomes:UP000054988}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MCA 2952 {ECO:0000313|EMBL:KTB42573.1,
RC ECO:0000313|Proteomes:UP000054988};
RA Aime M.C., Diaz-Valderrama J.R., Kijpornyongpan T., Phillips-Mora W.;
RT "Draft genome sequence of Moniliophthora roreri, the causal agent of frosty
RT pod rot of cacao.";
RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: The SPT4-SPT5 complex mediates both activation and inhibition
CC of transcription elongation, and plays a role in pre-mRNA processing.
CC This complex seems to be important for the stability of the RNA
CC polymerase II elongation machinery on the chromatin template but not
CC for the inherent ability of this machinery to translocate down the
CC gene. {ECO:0000256|ARBA:ARBA00024691, ECO:0000256|PIRNR:PIRNR036945}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PIRNR:PIRNR036945}.
CC -!- SIMILARITY: Belongs to the SPT5 family. {ECO:0000256|ARBA:ARBA00006956,
CC ECO:0000256|PIRNR:PIRNR036945}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KTB42573.1}.
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DR EMBL; LATX01001317; KTB42573.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0W0G1Y1; -.
DR eggNOG; KOG1999; Eukaryota.
DR Proteomes; UP000054988; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0032784; P:regulation of DNA-templated transcription elongation; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR GO; GO:0140673; P:transcription elongation-coupled chromatin remodeling; IEA:InterPro.
DR CDD; cd06081; KOW_Spt5_1; 1.
DR CDD; cd06082; KOW_Spt5_2; 1.
DR CDD; cd06083; KOW_Spt5_3; 1.
DR CDD; cd06084; KOW_Spt5_4; 1.
DR CDD; cd06085; KOW_Spt5_5; 1.
DR CDD; cd09888; NGN_Euk; 1.
DR Gene3D; 2.30.30.30; -; 3.
DR Gene3D; 3.30.70.940; NusG, N-terminal domain; 1.
DR InterPro; IPR005824; KOW.
DR InterPro; IPR041973; KOW_Spt5_1.
DR InterPro; IPR041975; KOW_Spt5_2.
DR InterPro; IPR041976; KOW_Spt5_3.
DR InterPro; IPR041977; KOW_Spt5_4.
DR InterPro; IPR041978; KOW_Spt5_5.
DR InterPro; IPR005100; NGN-domain.
DR InterPro; IPR006645; NGN-like_dom.
DR InterPro; IPR036735; NGN_dom_sf.
DR InterPro; IPR039385; NGN_Euk.
DR InterPro; IPR014722; Rib_uL2_dom2.
DR InterPro; IPR039659; SPT5.
DR InterPro; IPR024945; Spt5_C_dom.
DR InterPro; IPR022581; Spt5_N.
DR InterPro; IPR017071; TF_Spt5_eukaryote.
DR InterPro; IPR008991; Translation_prot_SH3-like_sf.
DR PANTHER; PTHR11125; SUPPRESSOR OF TY 5; 1.
DR PANTHER; PTHR11125:SF7; TRANSCRIPTION ELONGATION FACTOR SPT5; 1.
DR Pfam; PF12815; CTD; 1.
DR Pfam; PF00467; KOW; 1.
DR Pfam; PF03439; Spt5-NGN; 1.
DR Pfam; PF11942; Spt5_N; 1.
DR PIRSF; PIRSF036945; Spt5; 1.
DR SMART; SM01104; CTD; 1.
DR SMART; SM00739; KOW; 6.
DR SMART; SM00738; NGN; 1.
DR SUPFAM; SSF50104; Translation proteins SH3-like domain; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR036945};
KW Reference proteome {ECO:0000313|Proteomes:UP000054988};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|PIRNR:PIRNR036945}.
FT DOMAIN 172..262
FT /note="NusG-like N-terminal"
FT /evidence="ECO:0000259|SMART:SM00738"
FT DOMAIN 267..294
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT DOMAIN 424..451
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT DOMAIN 476..503
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT DOMAIN 598..623
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT DOMAIN 691..718
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT DOMAIN 784..918
FT /note="Spt5 C-terminal"
FT /evidence="ECO:0000259|SMART:SM01104"
FT DOMAIN 1031..1058
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT REGION 1..141
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 310..331
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 742..905
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 84..101
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 109..141
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 758..773
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 799..819
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 827..861
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1090 AA; 120034 MW; DF11373613F031E2 CRC64;
MSDVEDYEDY GAAAPEVDAR QEREDEGEDE EEPRRRKHDE EEDDDDEDEE DEEEEEQVSG
KKKKRTKRRH KRDSAARFID FEAEVSSDDE DDEDEAEMGN DGFIESNDLF DDDSTRRHHA
RLDTRRQFDE EEDKSPEQIA KDLSNRYRRT AVRYTGDMNE IPQRLLMPSV HDASLWQVRV
KPGRERDIVF SLMRKSLDVE FSARPLQILS AFQRDSLPGM IYVEARSSQQ VIHACNGLVG
VYPSRGVHLV PIEEMASLLQ IKKQEATVQL HSWVRIRRGK YQGDLAQVVD TSNPEEIGIR
FIPRIDLNPR DDGVDGRKRK KGVPVPSGSM RPPQRLFNFE EVVKVYGRTA VARRGPSGTF
VFQQDTYRDG FLEKDFKPSA LIMEEVNPTL DEITQFSRKA DGTSDSMVDL SIIAEASRKQ
AVAVLQPGDH VEVFEGEQAG VHGVVEQISQ DVVTITPVGL DIEQKVDLPA RSVRKRFKPG
DHVKVMAGKN ADETGLVVSV ADNVVTFLSD MSMQEVSVFS KDLREAAEVG SGTNIVGDYE
LHDLVQLDPQ TVGVIFKTER DSFRVLDQNG QARLVHPHQI SMRRDSNRAI ATDSEGHELR
INDNMKEVDG EGRKGRVLHI HQSFYAFLHN RDIVENGGVF VTRARSLISL APKGNLIKMA
PGTDLSKMNP ALAAPTGGMV GSGPMGRGPR DRLIGVSVTV IKGPHKGYVG TIKDTNGAIA
RVELHTGNKI ISIEKAKLHR RLNDGKTEPL EGPGATWGRN NRGNNNSMGP PQVPRTANPY
AAAGGRTPGW GGGRTPNPYA SGDSRTPAWN ASSRTPNPYA DGGRTPAWQP SSRTPNPYAN
GGQTPARNAT QPTSSWGGAT PGRNSGGWGS GDSGGWGGAT PGRGAEWGSE VWNVPTPAAA
PTPGLAPAAT PAFSAPTPGF FGLGGLSAPT PGMIPETPGA AFDDLSRQPH TPASDWILDA
QVRPYYNRLK VIVEGTTRGQ NYLDGIYENH IAIVLTATRA GENFDQTAYV RFTDDNEERS
FLMKHLMPCA PENVDEEAVV IYGERKGELV KVRQRPDGTD TTEMLVVEST GTNGAAFWEC
QKDWMSALAR
//
