ID A0A0W0GF97_9AGAR Unreviewed; 194 AA.
AC A0A0W0GF97;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=EKC/KEOPS complex subunit CGI121 {ECO:0000256|ARBA:ARBA00016009};
DE AltName: Full=EKC/KEOPS complex subunit cgi121 {ECO:0000256|ARBA:ARBA00015316};
GN ORFNames=WG66_186 {ECO:0000313|EMBL:KTB47241.1};
OS Moniliophthora roreri.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Marasmiineae; Marasmiaceae; Moniliophthora.
OX NCBI_TaxID=221103 {ECO:0000313|EMBL:KTB47241.1, ECO:0000313|Proteomes:UP000054988};
RN [1] {ECO:0000313|EMBL:KTB47241.1, ECO:0000313|Proteomes:UP000054988}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MCA 2952 {ECO:0000313|EMBL:KTB47241.1,
RC ECO:0000313|Proteomes:UP000054988};
RA Aime M.C., Diaz-Valderrama J.R., Kijpornyongpan T., Phillips-Mora W.;
RT "Draft genome sequence of Moniliophthora roreri, the causal agent of frosty
RT pod rot of cacao.";
RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the EKC/KEOPS complex that is required for the
CC formation of a threonylcarbamoyl group on adenosine at position 37
CC (t(6)A37) in tRNAs that read codons beginning with adenine. The complex
CC is probably involved in the transfer of the threonylcarbamoyl moiety of
CC threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. CGI121 acts as
CC an allosteric effector that regulates the t(6)A activity of the
CC complex. The EKC/KEOPS complex also promotes both telomere uncapping
CC and telomere elongation. The complex is required for efficient
CC recruitment of transcriptional coactivators. CGI121 is not required for
CC tRNA modification. {ECO:0000256|ARBA:ARBA00025043}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the CGI121/TPRKB family.
CC {ECO:0000256|ARBA:ARBA00005546, ECO:0000256|RuleBase:RU004398}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KTB47241.1}.
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DR EMBL; LATX01000082; KTB47241.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0W0GF97; -.
DR eggNOG; KOG4066; Eukaryota.
DR Proteomes; UP000054988; Unassembled WGS sequence.
DR GO; GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR Gene3D; 3.30.2380.10; CGI121/TPRKB; 1.
DR InterPro; IPR013926; CGI121/TPRKB.
DR InterPro; IPR036504; CGI121/TPRKB_sf.
DR PANTHER; PTHR15840; CGI-121 FAMILY MEMBER; 1.
DR PANTHER; PTHR15840:SF10; EKC_KEOPS COMPLEX SUBUNIT TPRKB; 1.
DR Pfam; PF08617; CGI-121; 1.
DR SUPFAM; SSF143870; PF0523-like; 1.
PE 3: Inferred from homology;
KW Chromosome {ECO:0000256|ARBA:ARBA00022895};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU004398};
KW Reference proteome {ECO:0000313|Proteomes:UP000054988};
KW Telomere {ECO:0000256|ARBA:ARBA00022895};
KW tRNA processing {ECO:0000256|ARBA:ARBA00022694}.
SQ SEQUENCE 194 AA; 21479 MW; 4E3600F6A2AEA249 CRC64;
MQSLAFDHAD ASDIAYVALF HPVNNAAQIR KRIIDAAKME GEEGEKERNA VNFAFIDATL
ITSVLHLQTV IHQAILAESE GMLRTKTVHS EVIFALNPTN NITESIRRYG VSDSSRALLV
VHITKRSQTH PVSEIEKNLS AAIDGVMVPL SELDGLTDWD RVKKYHKLNN LGENQLAYID
NIVVSSAAMK SVMQ
//
