ID A0A0W0R0L4_9GAMM Unreviewed; 181 AA.
AC A0A0W0R0L4;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=Ribosomal RNA small subunit methyltransferase D {ECO:0000256|ARBA:ARBA00013682, ECO:0000256|PIRNR:PIRNR004553};
DE EC=2.1.1.171 {ECO:0000256|ARBA:ARBA00012141, ECO:0000256|PIRNR:PIRNR004553};
GN Name=yhhF {ECO:0000313|EMBL:KTC64507.1};
GN ORFNames=Lade_1801 {ECO:0000313|EMBL:KTC64507.1}, NCTC12735_01517
GN {ECO:0000313|EMBL:VEH85875.1};
OS Legionella adelaidensis.
OG Plasmid 24 {ECO:0000313|EMBL:VEH85875.1,
OG ECO:0000313|Proteomes:UP000281170}.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Legionellales;
OC Legionellaceae; Legionella.
OX NCBI_TaxID=45056 {ECO:0000313|EMBL:KTC64507.1, ECO:0000313|Proteomes:UP000054859};
RN [1] {ECO:0000313|EMBL:KTC64507.1, ECO:0000313|Proteomes:UP000054859}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1762-AUS-E {ECO:0000313|EMBL:KTC64507.1,
RC ECO:0000313|Proteomes:UP000054859};
RA Burstein D., Amaro F., Zusman T., Lifshitz Z., Cohen O., Gilbert J.A.,
RA Pupko T., Shuman H.A., Segal G.;
RT "Identification of large and diverse effector repertoires of 38 Legionella
RT species.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:VEH85875.1, ECO:0000313|Proteomes:UP000281170}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC12735 {ECO:0000313|EMBL:VEH85875.1,
RC ECO:0000313|Proteomes:UP000281170};
RC PLASMID=24 {ECO:0000313|Proteomes:UP000281170};
RG Pathogen Informatics;
RL Submitted (DEC-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Specifically methylates the guanine in position 966 of 16S
CC rRNA in the assembled 30S particle. {ECO:0000256|ARBA:ARBA00002649,
CC ECO:0000256|PIRNR:PIRNR004553}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=guanosine(966) in 16S rRNA + S-adenosyl-L-methionine = H(+) +
CC N(2)-methylguanosine(966) in 16S rRNA + S-adenosyl-L-homocysteine;
CC Xref=Rhea:RHEA:23548, Rhea:RHEA-COMP:10211, Rhea:RHEA-COMP:10212,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:74269, ChEBI:CHEBI:74481; EC=2.1.1.171;
CC Evidence={ECO:0000256|ARBA:ARBA00000252,
CC ECO:0000256|PIRNR:PIRNR004553};
CC -!- SIMILARITY: Belongs to the methyltransferase superfamily. RsmD family.
CC {ECO:0000256|ARBA:ARBA00005269, ECO:0000256|PIRNR:PIRNR004553}.
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DR EMBL; LNKA01000019; KTC64507.1; -; Genomic_DNA.
DR EMBL; LR134433; VEH85875.1; -; Genomic_DNA.
DR RefSeq; WP_058462872.1; NZ_LR134433.1.
DR AlphaFoldDB; A0A0W0R0L4; -.
DR STRING; 45056.Lade_1801; -.
DR KEGG; ladl:NCTC12735_01517; -.
DR PATRIC; fig|45056.6.peg.1861; -.
DR OrthoDB; 9803017at2; -.
DR Proteomes; UP000054859; Unassembled WGS sequence.
DR Proteomes; UP000281170; Plasmid 24.
DR GO; GO:0052913; F:16S rRNA (guanine(966)-N(2))-methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR004398; RNA_MeTrfase_RsmD.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR NCBIfam; TIGR00095; 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD; 1.
DR PANTHER; PTHR43542; METHYLTRANSFERASE; 1.
DR PANTHER; PTHR43542:SF1; METHYLTRANSFERASE; 1.
DR Pfam; PF03602; Cons_hypoth95; 1.
DR PIRSF; PIRSF004553; CHP00095; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|PIRNR:PIRNR004553,
KW ECO:0000313|EMBL:KTC64507.1}; Plasmid {ECO:0000313|EMBL:VEH85875.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000054859};
KW rRNA processing {ECO:0000256|PIRNR:PIRNR004553};
KW S-adenosyl-L-methionine {ECO:0000256|PIRNR:PIRNR004553};
KW Transferase {ECO:0000256|PIRNR:PIRNR004553, ECO:0000313|EMBL:KTC64507.1}.
SQ SEQUENCE 181 AA; 20924 MW; EBFAE87433A2FB7E CRC64;
MNTVRIIGGI YKGKKLHFPS IEGLRPTPDR VKETVFNWLM HDIRDSHCLD VFAGSGNLGF
EAFSRGASKV IFIEHNRKAY ENIKNIIDSF HTKKLIAHHE NSMQYIESCK EEFDIVFLDP
PFAKDYLPSC MQLFSTLPIL KIGGLVYIES QQEMTLPETW WKKLKLKKAG QVVYGLYQKI
Q
//
