ID A0A0W0R4C2_9GAMM Unreviewed; 349 AA.
AC A0A0W0R4C2;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=3-hydroxyisobutyryl-CoA hydrolase {ECO:0000256|ARBA:ARBA00011915};
DE EC=3.1.2.4 {ECO:0000256|ARBA:ARBA00011915};
GN Name=echA8_1 {ECO:0000313|EMBL:VEH85519.1};
GN ORFNames=Lade_0557 {ECO:0000313|EMBL:KTC65899.1}, NCTC12735_01153
GN {ECO:0000313|EMBL:VEH85519.1};
OS Legionella adelaidensis.
OG Plasmid 18 {ECO:0000313|EMBL:VEH85519.1,
OG ECO:0000313|Proteomes:UP000281170}.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Legionellales;
OC Legionellaceae; Legionella.
OX NCBI_TaxID=45056 {ECO:0000313|EMBL:KTC65899.1, ECO:0000313|Proteomes:UP000054859};
RN [1] {ECO:0000313|EMBL:KTC65899.1, ECO:0000313|Proteomes:UP000054859}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1762-AUS-E {ECO:0000313|EMBL:KTC65899.1,
RC ECO:0000313|Proteomes:UP000054859};
RA Burstein D., Amaro F., Zusman T., Lifshitz Z., Cohen O., Gilbert J.A.,
RA Pupko T., Shuman H.A., Segal G.;
RT "Identification of large and diverse effector repertoires of 38 Legionella
RT species.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:VEH85519.1, ECO:0000313|Proteomes:UP000281170}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC12735 {ECO:0000313|EMBL:VEH85519.1,
RC ECO:0000313|Proteomes:UP000281170};
RC PLASMID=18 {ECO:0000313|Proteomes:UP000281170};
RG Pathogen Informatics;
RL Submitted (DEC-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-
CC methylpropanoate + CoA + H(+); Xref=Rhea:RHEA:20888,
CC ChEBI:CHEBI:11805, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57340; EC=3.1.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00001709};
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DR EMBL; LNKA01000001; KTC65899.1; -; Genomic_DNA.
DR EMBL; LR134427; VEH85519.1; -; Genomic_DNA.
DR RefSeq; WP_058461622.1; NZ_LR134427.1.
DR AlphaFoldDB; A0A0W0R4C2; -.
DR STRING; 45056.Lade_0557; -.
DR KEGG; ladl:NCTC12735_01153; -.
DR PATRIC; fig|45056.6.peg.578; -.
DR OrthoDB; 9790967at2; -.
DR Proteomes; UP000054859; Unassembled WGS sequence.
DR Proteomes; UP000281170; Plasmid 18.
DR GO; GO:0003860; F:3-hydroxyisobutyryl-CoA hydrolase activity; IEA:InterPro.
DR GO; GO:0004300; F:enoyl-CoA hydratase activity; IEA:UniProtKB-EC.
DR CDD; cd06558; crotonase-like; 1.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR045004; ECH_dom.
DR InterPro; IPR032259; HIBYL-CoA-H.
DR PANTHER; PTHR43176:SF3; 3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43176; 3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED; 1.
DR Pfam; PF16113; ECH_2; 1.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Lyase {ECO:0000313|EMBL:VEH85519.1}; Plasmid {ECO:0000313|EMBL:VEH85519.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000054859}.
FT DOMAIN 13..339
FT /note="Enoyl-CoA hydratase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF16113"
SQ SEQUENCE 349 AA; 39099 MW; 8C3A032023A43FA1 CRC64;
MNDSILFTQE KHIGLITLNR PTALNALTLP MILALQEQLS AWEQDNSIHA VVIKAEEGKA
FCAGGDVRWL YEAGKSNDPQ QMQFFLHEYR LNHYINQYKK PYIALMNGIT MGGGVGISLH
GSHPVASENF LFAMPETGIG FFPDIGASHL LSRCPYEFGT YLALTGHRLQ AEEAYHVGLV
KYLVTANEMN TLLAALINTD LSQNPAQEVD ACIKRFAFSI TSQVPQDATK IASIFNKSTM
EEILAQLDAN EHNFFQTTKD ILNQKAPLSL KVTLRQIKQA KHLSMGECVK MDYCLVSHFM
TASDFYEGVR ALLIDKDKNP QWSPQTLSEV TNDQVEAYFT CKDRPLLLT
//
