ID A0A0W0S5J5_9GAMM Unreviewed; 1055 AA.
AC A0A0W0S5J5;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE RecName: Full=Efflux pump membrane transporter {ECO:0000256|RuleBase:RU364070};
GN Name=mexF2 {ECO:0000313|EMBL:KTC78340.1};
GN ORFNames=Lbru_2632 {ECO:0000313|EMBL:KTC78340.1};
OS Legionella brunensis.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Legionellales;
OC Legionellaceae; Legionella.
OX NCBI_TaxID=29422 {ECO:0000313|EMBL:KTC78340.1, ECO:0000313|Proteomes:UP000054742};
RN [1] {ECO:0000313|EMBL:KTC78340.1, ECO:0000313|Proteomes:UP000054742}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43878 {ECO:0000313|EMBL:KTC78340.1,
RC ECO:0000313|Proteomes:UP000054742};
RA Burstein D., Amaro F., Zusman T., Lifshitz Z., Cohen O., Gilbert J.A.,
RA Pupko T., Shuman H.A., Segal G.;
RT "Genomic analysis of 38 Legionella species identifies large and diverse
RT effector repertoires.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429, ECO:0000256|RuleBase:RU364070}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004429,
CC ECO:0000256|RuleBase:RU364070}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. {ECO:0000256|ARBA:ARBA00010942,
CC ECO:0000256|RuleBase:RU364070}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KTC78340.1}.
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DR EMBL; LNXV01000033; KTC78340.1; -; Genomic_DNA.
DR RefSeq; WP_058442600.1; NZ_LNXV01000033.1.
DR AlphaFoldDB; A0A0W0S5J5; -.
DR STRING; 29422.Lbru_2632; -.
DR PATRIC; fig|29422.6.peg.2795; -.
DR OrthoDB; 9757904at2; -.
DR Proteomes; UP000054742; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015562; F:efflux transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0042908; P:xenobiotic transport; IEA:InterPro.
DR Gene3D; 3.30.70.1430; Multidrug efflux transporter AcrB pore domain; 2.
DR Gene3D; 3.30.70.1440; Multidrug efflux transporter AcrB pore domain; 1.
DR Gene3D; 3.30.70.1320; Multidrug efflux transporter AcrB pore domain like; 1.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR027463; AcrB_DN_DC_subdom.
DR InterPro; IPR001036; Acrflvin-R.
DR InterPro; IPR004764; MdtF-like.
DR InterPro; IPR000731; SSD.
DR NCBIfam; TIGR00915; 2A0602; 1.
DR PANTHER; PTHR32063; -; 1.
DR PANTHER; PTHR32063:SF11; EFFLUX PUMP MEMBRANE TRANSPORTER; 1.
DR Pfam; PF00873; ACR_tran; 1.
DR PRINTS; PR00702; ACRIFLAVINRP.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 3: Inferred from homology;
KW Cell inner membrane {ECO:0000256|RuleBase:RU364070};
KW Cell membrane {ECO:0000256|RuleBase:RU364070};
KW Membrane {ECO:0000256|RuleBase:RU364070};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU364070};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU364070}; Transport {ECO:0000256|RuleBase:RU364070}.
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 340..362
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 369..389
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 395..416
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 437..460
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 472..499
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 544..563
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 875..895
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 902..926
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 932..955
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 976..996
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 1008..1035
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT DOMAIN 334..497
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
SQ SEQUENCE 1055 AA; 115821 MW; 78BA9F414DFAF8E8 CRC64;
MKIAHFFIER PIFASVIAII IVLIGGLSYF NLPIEQYPQV VPPTIQVTAS YPGANAKTVA
ETVATPIEQE VNGVEGMLYM DSQSTDDGQM RLTITFKLGT DLDLAQVLVQ NRVAIAEPRL
PEEVRRIGLT TVKNSPDLML VINLFSPDGR YDQTYLGNYA VLNIRDKIRR IEGVGNVRLV
GASEYAMRIW LDPDLINSYD LAAEDIVEAL RTQNVQIASG TLNSQPQKQQ YGIEYHIETQ
GRLVNPQEFE NIIVKSGANG RIVRLKDVGR VELGAQDYFT QGYLGSFPAI ALPVFQRPGT
NALATAKEIL ATMKEISKEF PPGIQYKIAY NPTEFIAESI GAVFTTIYEA ILLVVLVILI
FLQSWRAAII PIIAIPVSLI GTFAVMQAIG FSLNYLTLFG LVLAIGIVVD DAIVVVENME
RNIRAGMNSR DAAKKTMTEV GSALVAIGLV LVAVFLPTIF LEGISGRFYQ QFGSTIAVAT
VISVFISLTL SPSLAAILLK AHKKEKETMF SIRHPLKSFL NGFNRGFDYV STQYGKLVAK
LTRLTGLMLV IYLLLIASTF FLFKFVPTGF IPKQDQGYFI ISVQLPPGAS LDRTNKVVKK
ALRKILAIPG ISNAVGFTGF AGATFTNSSN AAAIFPVLDS FKKRKEQGIS YNDLLAKLRQ
EMWSIKEAMI VVIPPPPVRG IGNAGGFKMM VQDRDGRGIE VLSEAVANLA EKANQADATT
SVFTFFENST PRIHLALERD KAERLGVPIS RVIETLEVYL GSVFLNEFNY LGRTFRVMAQ
ADALHRLTAD DILRLKVRNS SGDMVPIGSV ATLKDTIGPS RMPRYNLYPA IDLLGDVKPG
YSSGEALATM EKLAAQILPD GISYEWTELA YQQKMVGNTA TIAFILGVVF VFLLLSAQYE
SWVLPIAIIL IVPMCLFSSL IGIKILGMEN NVMTQLGFIV LIGLASKNAI LIVEFARQLE
NAGANRWKAA IQAAKLRLRP ILMTSFAFIL GVYPLVIASG AGAEMRRALG VAVFSGMIGV
TFFGLVFTPI FYVLISRLAN YRPKIKLSHH REEQG
//
