ID A0A0W0SDI0_9GAMM Unreviewed; 401 AA.
AC A0A0W0SDI0;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=UDP-N-acetylglucosamine 2-epimerase (non-hydrolyzing) {ECO:0000256|ARBA:ARBA00038858};
DE EC=5.1.3.14 {ECO:0000256|ARBA:ARBA00038858};
GN Name=wecB {ECO:0000313|EMBL:KTC81440.1};
GN ORFNames=Lbru_1960 {ECO:0000313|EMBL:KTC81440.1};
OS Legionella brunensis.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Legionellales;
OC Legionellaceae; Legionella.
OX NCBI_TaxID=29422 {ECO:0000313|EMBL:KTC81440.1, ECO:0000313|Proteomes:UP000054742};
RN [1] {ECO:0000313|EMBL:KTC81440.1, ECO:0000313|Proteomes:UP000054742}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43878 {ECO:0000313|EMBL:KTC81440.1,
RC ECO:0000313|Proteomes:UP000054742};
RA Burstein D., Amaro F., Zusman T., Lifshitz Z., Cohen O., Gilbert J.A.,
RA Pupko T., Shuman H.A., Segal G.;
RT "Genomic analysis of 38 Legionella species identifies large and diverse
RT effector repertoires.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=UDP-N-acetyl-alpha-D-glucosamine = UDP-N-acetyl-alpha-D-
CC mannosamine; Xref=Rhea:RHEA:17213, ChEBI:CHEBI:57705,
CC ChEBI:CHEBI:68623; EC=5.1.3.14;
CC Evidence={ECO:0000256|ARBA:ARBA00036080};
CC -!- SIMILARITY: Belongs to the UDP-N-acetylglucosamine 2-epimerase family.
CC {ECO:0000256|ARBA:ARBA00038209, ECO:0000256|RuleBase:RU003513}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KTC81440.1}.
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DR EMBL; LNXV01000029; KTC81440.1; -; Genomic_DNA.
DR RefSeq; WP_065235454.1; NZ_LNXV01000029.1.
DR AlphaFoldDB; A0A0W0SDI0; -.
DR STRING; 29422.Lbru_1960; -.
DR PATRIC; fig|29422.6.peg.2090; -.
DR OrthoDB; 9803238at2; -.
DR Proteomes; UP000054742; Unassembled WGS sequence.
DR GO; GO:0008761; F:UDP-N-acetylglucosamine 2-epimerase activity; IEA:InterPro.
DR CDD; cd03786; GTB_UDP-GlcNAc_2-Epimerase; 1.
DR Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 2.
DR InterPro; IPR003331; UDP_GlcNAc_Epimerase_2_dom.
DR InterPro; IPR029767; WecB-like.
DR NCBIfam; TIGR00236; wecB; 1.
DR PANTHER; PTHR43174; UDP-N-ACETYLGLUCOSAMINE 2-EPIMERASE; 1.
DR PANTHER; PTHR43174:SF2; UDP-N-ACETYLGLUCOSAMINE 2-EPIMERASE; 1.
DR Pfam; PF02350; Epimerase_2; 1.
DR SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000256|RuleBase:RU003513}.
FT DOMAIN 22..370
FT /note="UDP-N-acetylglucosamine 2-epimerase"
FT /evidence="ECO:0000259|Pfam:PF02350"
SQ SEQUENCE 401 AA; 44536 MW; F76D7AB03107037C CRC64;
MINTLTVFGT RPEAIKLAPV IRELKAHSQV NNKICVTGQH QQMLQPVLDL FNIKPDFNLN
VMSKNQGLTT LTTKILTGLE ELFNNFKPHL VLVHGDTTTT FAASLSAYYH QIPVAHIEAG
LRTGNINSPW PEEANRKLAG ALAAIHFAPT ELARDNLLRE GVLPEKIYVT GNTVIDALFE
MTRKIDAELE FDIQLAKSFP FLTANRKVIL VTGHRRENFG VGFEQICHAI KQIAISFPEV
DIVYPVHLNP NVQQPVNSML GGIPNIYLIE PVNYLPFIYL MKRSYLILTD SGGIQEEAPS
LGKPVLVMRD TTERLEAIIA GTVKLVGSNI ENIVNGVKEL LTDEQVYLGM SEANNPYGDG
LASSRIMRII SQVTLKPDSH EDVVSKEIEK NKITPKEESL V
//
