ID A0A0W0SSS9_9GAMM Unreviewed; 1076 AA.
AC A0A0W0SSS9;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
DE AltName: Full=DNA 3'-5' helicase II {ECO:0000256|ARBA:ARBA00034923};
GN ORFNames=Lbru_0379 {ECO:0000313|EMBL:KTC86438.1};
OS Legionella brunensis.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Legionellales;
OC Legionellaceae; Legionella.
OX NCBI_TaxID=29422 {ECO:0000313|EMBL:KTC86438.1, ECO:0000313|Proteomes:UP000054742};
RN [1] {ECO:0000313|EMBL:KTC86438.1, ECO:0000313|Proteomes:UP000054742}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43878 {ECO:0000313|EMBL:KTC86438.1,
RC ECO:0000313|Proteomes:UP000054742};
RA Burstein D., Amaro F., Zusman T., Lifshitz Z., Cohen O., Gilbert J.A.,
RA Pupko T., Shuman H.A., Segal G.;
RT "Genomic analysis of 38 Legionella species identifies large and diverse
RT effector repertoires.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KTC86438.1}.
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DR EMBL; LNXV01000004; KTC86438.1; -; Genomic_DNA.
DR RefSeq; WP_058440490.1; NZ_LNXV01000004.1.
DR AlphaFoldDB; A0A0W0SSS9; -.
DR STRING; 29422.Lbru_0379; -.
DR PATRIC; fig|29422.6.peg.396; -.
DR OrthoDB; 9810135at2; -.
DR Proteomes; UP000054742; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}.
FT DOMAIN 1..485
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 497..757
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 22..29
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1076 AA; 124045 MW; 4633C3A69EC7686C CRC64;
MLKDSQQRIQ ATDPRRSFIV QAPAGSGKTE ILTQRYLRLL STVTAPEQII ALTFTRKAAS
EMRERILLAL KQAVSGIKPA SPHQQQTFLY AQEALARSQE LNWQLLKQPG RLRIMTLDAL
CQTISHTIPL QEKQIPYAQI ADNPQVHYQT AARSCLAHAL ADEAFHQPLK HLLKHLDNRQ
DKLLSLFSDL LASRDQWLSV LYIAKEQTQT CFEEMLKILE QHELARFKQS VPLACRTELC
SLARQVAEIE ANPQSPRYLL RDWENYDQLN RELGISLAAL LLTSQNTLRQ SFDHHVGLKR
GACDNHLYDN LKSASKDLLA NLGTESKFLE ALLKIKDLPL PRYDPEQWQV LQALFTLLPL
LAGHLHLVFN ENNELDFTAV SQQALYALGN DEDPTDLALY LDNSIHHLLI DEFQDTSIQQ
FQLLTKLVHG WQQNDGRTLF IVGDPMQSIY RFRQAEVGLF LRAKQHGIGS VQLESLELCC
NFRSTETIVN WVNQQFQTIF PKIDDIESGA ISFHHSINIL PSTENSYIKA YQFTDRNKEA
EAVIACAIAE LQNNPNDEIA ILVRSRSQLI EITRLLRERQ ISFQGVEIEF LSKLPHLRDL
WSLTQALLMP ANRLAWLALL RSPFCGLPLS ELHLIANLDR NKSIYYALSQ LDKLSLSKES
HIRLQFIYQI LKNALISRHQ DSIVDWIAST FKQLQGEQIL TTTQQADLEQ FWLLLERFTA
KGQLPNLEQF KIEFNQLYSQ CNNPSRLQVM TIHKSKGLEF DCVILPGLGT KSSNHDQPLF
RWLKLPSSDK KDLLLISPIK PAYRDHCLVY NYLANIDAEK DSYELQRLLY VAVTRAKKRL
CLFDNREKDT KGTFRSLLRN QDFIATPKET DETQPQMPPP SRYQLPIDFY LNPPVINSQE
IPSTEIPYPN NARQIGIVTH ELLQWICNYH PQHIQELPWP MVINRFKSMG FEEKELSEAC
ENLRAQIDHL LNEPIGQWLT QIHEQEFNEY ALLINKEGTA STRIIDRTFI HKGQRWIIDF
KTGSEEVSAQ RKHRQQVNEY ASFFADSNHP IRCGLYYLAS GTWLEWNYAE ESALPV
//
