ID A0A0W0TH51_9GAMM Unreviewed; 386 AA.
AC A0A0W0TH51;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN Name=taqIM {ECO:0000313|EMBL:KTC94890.1};
GN ORFNames=Lfee_2554 {ECO:0000313|EMBL:KTC94890.1}, NCTC12022_02783
GN {ECO:0000313|EMBL:SPX62026.1};
OS Legionella feeleii.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Legionellales;
OC Legionellaceae; Legionella.
OX NCBI_TaxID=453 {ECO:0000313|EMBL:KTC94890.1, ECO:0000313|Proteomes:UP000054698};
RN [1] {ECO:0000313|EMBL:KTC94890.1, ECO:0000313|Proteomes:UP000054698}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WO-44C {ECO:0000313|EMBL:KTC94890.1,
RC ECO:0000313|Proteomes:UP000054698};
RA Burstein D., Amaro F., Zusman T., Lifshitz Z., Cohen O., Gilbert J.A.,
RA Pupko T., Shuman H.A., Segal G.;
RT "Genomic analysis of 38 Legionella species identifies large and diverse
RT effector repertoires.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:SPX62026.1, ECO:0000313|Proteomes:UP000251942}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC12022 {ECO:0000313|EMBL:SPX62026.1,
RC ECO:0000313|Proteomes:UP000251942};
RG Pathogen Informatics;
RA Doyle S.;
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- SIMILARITY: Belongs to the N(4)/N(6)-methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00006594}.
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DR EMBL; LNYB01000085; KTC94890.1; -; Genomic_DNA.
DR EMBL; UASS01000032; SPX62026.1; -; Genomic_DNA.
DR RefSeq; WP_058447404.1; NZ_UASS01000032.1.
DR AlphaFoldDB; A0A0W0TH51; -.
DR STRING; 453.Lfee_2554; -.
DR PATRIC; fig|453.4.peg.2801; -.
DR OrthoDB; 9782445at2; -.
DR Proteomes; UP000054698; Unassembled WGS sequence.
DR Proteomes; UP000251942; Unassembled WGS sequence.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR011639; MethylTrfase_TaqI-like_dom.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR41313; ADENINE-SPECIFIC METHYLTRANSFERASE; 1.
DR PANTHER; PTHR41313:SF1; DNA METHYLASE ADENINE-SPECIFIC DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF07669; Eco57I; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000313|EMBL:KTC94890.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000054698};
KW Transferase {ECO:0000313|EMBL:KTC94890.1}.
FT DOMAIN 155..255
FT /note="Type II methyltransferase M.TaqI-like"
FT /evidence="ECO:0000259|Pfam:PF07669"
SQ SEQUENCE 386 AA; 43975 MW; 36199A80F7038E38 CRC64;
MSDNVFNVQR VAHNLEVLAE LKSASPNPDV LKRYTGWGGL RNAVYTSNVY RVLKQHCSES
EIASIKKTIS NAYYTPSALI ECVFDGLLRL SRPFQTILEP SVGHGLFFEH MPDEWRRGAL
YAVEMDEVSC QLFQQLYPDV SLHQGGFETC QPPIAFDLIL GNPPYGQAVV ADASHPDISR
LRIHHFFVAK CMRLLAPGGI LAMVLPRYFL DNRQDHARGI IHQEGGSLLA AYRLPDNLFA
DAKVTVDLVF LVKEKGEEDW LYVDKIKIDN RVSHINRYFS INPSHIIGEL AMVEAYGRYE
LACRQPSKGD PFALLKQLLT YFPPKKLPTL DECKIKLNKR LELVDKDIQS LSLMKNRLLQ
AQRDLQRMER QFLQRCVDTV NVQSLS
//
