ID A0A0W0U667_9GAMM Unreviewed; 1081 AA.
AC A0A0W0U667;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
DE AltName: Full=DNA 3'-5' helicase II {ECO:0000256|ARBA:ARBA00034923};
GN Name=addA {ECO:0000313|EMBL:SPX61347.1};
GN ORFNames=Lfee_0473 {ECO:0000313|EMBL:KTD03117.1}, NCTC12022_02087
GN {ECO:0000313|EMBL:SPX61347.1};
OS Legionella feeleii.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Legionellales;
OC Legionellaceae; Legionella.
OX NCBI_TaxID=453 {ECO:0000313|EMBL:KTD03117.1, ECO:0000313|Proteomes:UP000054698};
RN [1] {ECO:0000313|EMBL:KTD03117.1, ECO:0000313|Proteomes:UP000054698}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WO-44C {ECO:0000313|EMBL:KTD03117.1,
RC ECO:0000313|Proteomes:UP000054698};
RA Burstein D., Amaro F., Zusman T., Lifshitz Z., Cohen O., Gilbert J.A.,
RA Pupko T., Shuman H.A., Segal G.;
RT "Genomic analysis of 38 Legionella species identifies large and diverse
RT effector repertoires.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:SPX61347.1, ECO:0000313|Proteomes:UP000251942}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC12022 {ECO:0000313|EMBL:SPX61347.1,
RC ECO:0000313|Proteomes:UP000251942};
RG Pathogen Informatics;
RA Doyle S.;
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
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DR EMBL; LNYB01000016; KTD03117.1; -; Genomic_DNA.
DR EMBL; UASS01000018; SPX61347.1; -; Genomic_DNA.
DR RefSeq; WP_058443691.1; NZ_UASS01000018.1.
DR AlphaFoldDB; A0A0W0U667; -.
DR STRING; 453.Lfee_0473; -.
DR PATRIC; fig|453.4.peg.513; -.
DR OrthoDB; 9810135at2; -.
DR Proteomes; UP000054698; Unassembled WGS sequence.
DR Proteomes; UP000251942; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000054698}.
FT DOMAIN 1..485
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 497..758
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 22..29
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1081 AA; 123651 MW; 4E8111E6D158DCA3 CRC64;
MLKDSQQRLQ ATDPRRSFIV QAPAGSGKTE ILTQRYLRLL GHVNEPEQIV ALTFTRKAAS
EMRERIILAL QQAASGLCPA SAHQQQTYSY AAEALNRCAE RGWQLLQQPG RLRIITIDSL
CQTLCQAIPL QEKQVPYAQI SEYPERHYQA AARACFAHAL SDINLHQPLK CLLQHLDNRQ
DKFLELLSEL LANRDQWLTP LYSARAQSRT NYEQMLLFIE QHELTRFKQS TPVHCQDDLC
QLVRQFASLE TNPDSPRYSL RNWHSFAQLD RTLVANLAAL ILTSQGHLRK SFDHHVGLKR
GICEDDLYNH LKENSKAILS QLEDAPDFLD ALLRVQHLPA PHYDPEQWEV LQALFTLLPL
LVGHLHLIFS EQNEVDFAAI SQQALLALGD EEHPTDLTLF LDNAIHHLLV DEFQDTSIQQ
FQLLTKLVCG WQPDDGKTLF VVGDPMQSIY RFRQAEVGLF LKAKQQGIGP VQLTPLELCC
NFRSTATLVD WVNHQFRTIF PQLDDMESGA VSFHPSTNVL PADGNSYVIA QQFPDRQQEA
QALIKCVVAE LEANPNSDIA ILVRSRNQLT DIMQLLREQQ ISFQGVEIEL LARLPHLRDL
WSLTQALLRP ANRLAWLALL RSPCAGLSLA DLHLLANFDK KKSIYHALSQ LDNIVSLSEE
GRTRARFVYT VLQEALACRH QQSFSGWIAQ SFRQLHGDKI LTATEQADLE QFWLLIDRCT
PNGQLPEWDY FNNEFNRLYS QRTSPSRLHV MTIHKSKGLE FDCVILPGLS SKARNQDNPL
LRWLKLPSKK HGELLLVSPV KAAHREQCLL YDYLGKLDSE KNSYELQRLL YVAVTRAKKR
LFLFDSSEKE SQGTFRSFLK HEEFLTQEER LQAIMPSEKL PELYRLPLSF YADLPSMSFS
KTPATTLLPA DSNARQLGIV AHELLQWICD HHPGTSENLP WPLVMNQLKS LGLDKTEQDS
VYAMLQQQIA HLFKDPIGQW LIQPHAEEKN EYELLVSEQG TVSTRIIDRT FIAQGCRWII
DFKTGSEQIE AQKNHQQQVN EYARLLAALR SEPIKCGLYY LASGHWVQWD YTGHLALSST
E
//
