ID A0A0W0U8N0_9GAMM Unreviewed; 624 AA.
AC A0A0W0U8N0;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=Nucleoside-diphosphate sugar epimerase {ECO:0000313|EMBL:KTD04339.1};
DE EC=5.1.3.2 {ECO:0000313|EMBL:SPX62866.1};
GN Name=capD {ECO:0000313|EMBL:KTD04339.1};
GN ORFNames=Lfee_0166 {ECO:0000313|EMBL:KTD04339.1}, NCTC12022_03635
GN {ECO:0000313|EMBL:SPX62866.1};
OS Legionella feeleii.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Legionellales;
OC Legionellaceae; Legionella.
OX NCBI_TaxID=453 {ECO:0000313|EMBL:KTD04339.1, ECO:0000313|Proteomes:UP000054698};
RN [1] {ECO:0000313|EMBL:KTD04339.1, ECO:0000313|Proteomes:UP000054698}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WO-44C {ECO:0000313|EMBL:KTD04339.1,
RC ECO:0000313|Proteomes:UP000054698};
RA Burstein D., Amaro F., Zusman T., Lifshitz Z., Cohen O., Gilbert J.A.,
RA Pupko T., Shuman H.A., Segal G.;
RT "Genomic analysis of 38 Legionella species identifies large and diverse
RT effector repertoires.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:SPX62866.1, ECO:0000313|Proteomes:UP000251942}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC12022 {ECO:0000313|EMBL:SPX62866.1,
RC ECO:0000313|Proteomes:UP000251942};
RG Pathogen Informatics;
RA Doyle S.;
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the polysaccharide synthase family.
CC {ECO:0000256|ARBA:ARBA00007430}.
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DR EMBL; LNYB01000008; KTD04339.1; -; Genomic_DNA.
DR EMBL; UASS01000040; SPX62866.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0W0U8N0; -.
DR STRING; 453.Lfee_0166; -.
DR PATRIC; fig|453.4.peg.185; -.
DR OrthoDB; 9803111at2; -.
DR Proteomes; UP000054698; Unassembled WGS sequence.
DR Proteomes; UP000251942; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0003978; F:UDP-glucose 4-epimerase activity; IEA:UniProtKB-EC.
DR CDD; cd05237; UDP_invert_4-6DH_SDR_e; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR003869; Polysac_CapD-like.
DR PANTHER; PTHR43318:SF1; POLYSACCHARIDE BIOSYNTHESIS PROTEIN EPSC-RELATED; 1.
DR PANTHER; PTHR43318; UDP-N-ACETYLGLUCOSAMINE 4,6-DEHYDRATASE; 1.
DR Pfam; PF13727; CoA_binding_3; 1.
DR Pfam; PF02719; Polysacc_synt_2; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000313|EMBL:SPX62866.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000054698};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 15..35
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 47..69
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 90..111
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 117..134
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 291..573
FT /note="Polysaccharide biosynthesis protein CapD-like"
FT /evidence="ECO:0000259|Pfam:PF02719"
SQ SEQUENCE 624 AA; 70215 MW; 91DF38E874635F19 CRC64;
MQNIGTFFLK LYKKLPVIAF DVIAIPVAWY FAYWLRYNMQ PFPSSLVTVH SLFALLILMT
MQITCYYYFR VYRGLWRFSS LNDVARIIKA TVCATILSIP VFYLASLLQH IPRSVFPLYN
MILITLLCSG RLLMRSLWDK RGREGQVSEV KRVLIIGAGR AGESLVRDLK RTQSYQPVGF
VDDNLGKRGL EVHGIRVLGT SRDLLDLVIK HHVDLIFIAI PSAGSAAMRR IVSHCEKSNV
PFRTLPSIPA LVAGRVEVNA LRDVNIEDLL GRDQVQLQWD KIAANIKNKR VIVTGGGGSI
GSELCRQIMA LEPGKLLIVE NSEFNLYKIE QELSERFPQI PLELGLVSVT DKIAIDYLFD
QFKPQMVFHA AAYKHVPMLE DQIRVAIQNN VLGTQIVAEA SVAVGVEKFI LISTDKAVNP
ANVMGTTKRV AEIYCQNLNE RVDTQFITVR FGNVLGSAGS VVPLFQKQLQ AGGPLTVTHP
DIQRYFMTIP EACQLILQAM VNGHGGEIFV LDMGEPIKIS YLAEQMIRLA GKEPGKDIAI
EYTGLRPGEK LFEELFHVSE QLAPTEHEKL FKAKFRQLEW HELIQTIRLL NTACAMHHNE
ELYVLLKSLV PEFNSQVEKG AVVN
//
